"Ligand: 3503
",,,,,,,,,,,,,,,,,,,,
Pharma Model,Num Feature,Fit,Norm Fit,zscore,Num Hydrophobic,Num HB Acceptor,Num HB Donor,Num Positive,Num Negative,Num Aromatic,Name,Class,Uniplot,Function,Disease,Idication,,,,"
"
1v1f_v,3,2.988,0.9961,0.672235,3,0,0,0,0,0,Calcineurin B-like protein 4,NONE,O81223,Involved in calcium ion binding,NONE,NONE,,,,"
"
1psc_v,3,2.988,0.9959,0.852035,3,0,0,0,0,0,Parathion hydrolase,NONE,P0A433,Involved in zinc ion binding,NONE,NONE,,,,"
"
1j96_v,3,2.983,0.9942,0.860643,3,0,0,0,0,0,Aldo-keto reductase family 1 member C2,OXIDOREDUCTASE,AK1C2_HUMAN,Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-,NONE,NONE,,,,"
"
1zei_v,3,2.979,0.9929,0.894558,2,0,1,0,0,0,Insulin,NONE,P01315,"Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.",NONE,NONE,,,,"
"
1ohs_v,3,2.973,0.9909,0.764926,3,0,0,0,0,0,Steroid Delta-isomerase,NONE,P00947,Involved in steroid delta-isomerase activity,NONE,NONE,,,,"
"
1oo6_v,3,2.973,0.9909,0.830445,2,1,0,0,0,0,Oxygen-insensitive NAD(P)H nitroreductase,NONE,P38489,Energy production and conversion,NONE,For the symptomatic relief of patients with interstitial cystitis.,,,,"
"
1hqd_v,3,2.972,0.9906,0.860378,2,1,0,0,0,0,Lipase,NONE,P22088,Catalyzes the hydrolysis of triglycerides.,NONE,NONE,,,,"
"
1okl_v,3,2.969,0.9897,0.869142,2,1,0,0,0,0,Carbonic anhydrase 2,LYASE,CAH2_HUMAN,Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide.,"Defects in CA2 are the cause of autosomal recessive osteopetrosis type 3 (OPTB3) [MIM:259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.",NONE,,,,"
"
1i06_v,3,2.967,0.989,0.816576,3,0,0,0,0,0,Major urinary protein 2,NONE,P11589,Involved in phermone binding,NONE,NONE,,,,"
"
2oji_v,3,2.964,0.988,0.886708,2,1,0,0,0,0,Mitogen-activated protein kinase 1,TRANSFERASE,MK01_HUMAN,"Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosp",NONE,NONE,,,,"
"
1igx_v,3,2.959,0.9862,0.613979,3,0,0,0,0,0,Prostaglandin G/H synthase 1,NONE,P05979,Involved in peroxidase activity,NONE,NONE,,,,"
"
1c0t_v,3,2.955,0.985,0.846248,3,0,0,0,0,0,Gag-Pol polyprotein,NONE,P04585,"Gag-Pol polyprotein: Mediates, with Gag polyrotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi). Gag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, the polyprotein would promote translation, whereas at high concentration, the polyprotein would encapsidate genomic RNA and then shutt off translation.",NONE,NONE,,,,"
"
3bgp_v,3,2.949,0.983,0.695807,3,0,0,0,0,0,Proto-oncogene serine/threonine-protein kinase Pim-1,NONE,P11309,Involved in protein kinase activity,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1ued_v,3,2.947,0.9825,0.944704,0,3,0,0,0,0,Cytochrome P450 165C4,NONE,Q8RN03,Involved in monooxygenase activity,NONE,NONE,,,,"
"
1jdj_v,3,2.945,0.9816,0.748918,2,1,0,0,0,0,"Glycerol-3-phosphate dehydrogenase [NAD+], glycosomal",NONE,P90551,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1quh_v,3,2.935,0.9784,0.699224,2,1,0,0,0,0,Lysozyme,NONE,P00720,Involved in lysozyme activity,NONE,For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.,,,,"
"
1uow_v,3,2.925,0.9751,0.864051,0,1,2,0,0,0,Synaptotagmin-1,NONE,P21707,"May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes.",NONE,NONE,,,,"
"
1lyw_v,3,2.925,0.9749,0.843639,1,2,0,0,0,0,Cathepsin D,ASPARTIC PROTEASE,CATD_HUMAN,Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.,"Defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. The neuronal ceroid lipofuscinosis are a group of progressive neurodegenerative diseases in children and in adults, characterized by visual and mental decline, motor disturbance, epilepsy and behavioral changes.",NONE,,,,"
"
1dvz_v,3,2.918,0.9727,0.686425,2,1,0,0,0,0,Transthyretin,HORMONE/GROWTH FACTOR,TTHY_HUMAN,Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.,"Defects in TTR are the cause of amyloidosis type 1 (AMYL1) [MIM:176300]. AMYL1 is a hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis.;Defects in TTR are the cause of amyloidosis type 7 (AMYL7) [MIM:105210]; also known as leptomeningeal amyloidosis or meningocerebrovascular amyloidosis. AMYL7 is a form of hereditary transthyretin amyloidosis characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Mild systemic amyloidosis may occurr.;Defects in TTR are a cause of hyperthyroxinemia [MIM:176300].",NONE,,,,"
"
1gzm_v,3,2.916,0.9721,0.531401,3,0,0,0,0,0,Rhodopsin,NONE,P02699,Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).,NONE,NONE,,,,"
"
2p3g_v,3,2.915,0.9718,0.621093,3,0,0,0,0,0,MAP kinase-activated protein kinase 2,NONE,P49137,Involved in protein kinase activity,NONE,NONE,,,,"
"
3gch_v,3,2.913,0.971,0.458728,3,0,0,0,0,0,Chymotrypsinogen A,NONE,P00766,Involved in protease activity,NONE,NONE,,,,"
"
1h5w_v,3,2.912,0.9708,0.514936,3,0,0,0,0,0,Upper collar protein,NONE,P04332,This protein is located between the head and the tail of this bacteriophage,NONE,NONE,,,,"
"
3gam_v,3,2.91,0.97,0.835117,2,1,0,0,0,0,Ribosyldihydronicotinamide dehydrogenase [quinone],NONE,P16083,Involved in oxidoreductase activity,NONE,"Some evidence suggests that NADH might be useful in treating Parkinsons disease, chronic fatigue syndrome, Alzheimers disease and cardiovascular disease.",,,,"
"
1md3_v,3,2.908,0.9692,0.701175,1,2,0,0,0,0,Glutathione S-transferase P,TRANSFERASE,GSTP1_HUMAN,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,NONE,NONE,,,,"
"
1aur_v,3,2.899,0.9662,0.773444,1,2,0,0,0,0,Carboxylesterase 2,NONE,Q53547,Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity,NONE,NONE,,,,"
"
1v3m_v,3,2.894,0.9648,0.812429,0,2,1,0,0,0,Cyclomaltodextrin glucanotransferase,NONE,P05618,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
2cgw_v,3,2.877,0.9589,0.770481,1,1,1,0,0,0,Serine/threonine-protein kinase Chk1,TRANSFERASE,CHK1_HUMAN,Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X- S/T].,NONE,Cancer;Solid tumor,,,,"
"
1xzz_v,3,2.868,0.956,0.77381,0,2,1,0,0,0,"Inositol 1,4,5-trisphosphate receptor type 1",NONE,P11881,"Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (PubMed:23542070). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.",NONE,NONE,,,,"
"
1mid_v,3,2.864,0.9547,0.638811,3,0,0,0,0,0,Non-specific lipid-transfer protein 1,NONE,P07597,Involved in lipid binding,NONE,NONE,,,,"
"
1l0i_v,3,2.861,0.9536,0.706714,1,1,1,0,0,0,Acyl carrier protein,NONE,P0A6A8,Carrier of the growing fatty acid chain in fatty acid biosynthesis.,NONE,NONE,,,,"
"
1dx6_v,3,2.861,0.9535,0.62146,1,2,0,0,0,0,Acetylcholinesterase,SERINE HYDROLASE,ACES_TORCA,Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.,NONE,NONE,,,,"
"
1oj9_v,3,2.855,0.9518,0.578974,3,0,0,0,0,0,Amine oxidase [flavin-containing] B,OXIDOREDUCTASE,AOFB_HUMAN,Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phe,NONE,Alzheimers disease;Cocaine addiction;Major depressive disorder;Epilepsy;Neurodegenerative disease;Attention deficit hyperactivity disorder;Head injury;Parkinsons disease;Dementia;Nicotine dependence;Cerebrovascular ischemia,,,,"
"
1shj_v,3,2.855,0.9516,0.403999,3,0,0,0,0,0,Caspase-7,HYDROLASE,CASP7_HUMAN,Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp-,-Gly- 217 bond. Overe,NONE,NONE,,,"
"
2f1g_v,3,2.852,0.9506,0.711052,1,1,1,0,0,0,Cathepsin S,HYDROLASE,CATS_HUMAN,Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.,NONE,Psoriasis;Arteriosclerosis;Pain;Rheumatoid arthritis;Autoimmune disease;Allergy;Inflammation;Asthma;Multiple sclerosis;Immune disorder,,,,"
"
1yc9_v,3,2.846,0.9485,0.628785,2,1,0,0,0,0,"Multidrug resistance protein, putative",NONE,Q9KS51,Involved in transporter activity,NONE,NONE,,,,"
"
1i30_v,3,2.843,0.9475,0.505837,1,1,1,0,0,0,Enoyl-[acyl-carrier-protein] reductase [NADH],NONE,P0AEK4,Lipid transport and metabolism,NONE,NONE,,,,"
"
1reu_v,3,2.842,0.9474,0.0202165,3,0,0,0,0,0,Bone morphogenetic protein 2,HORMONE/GROWTH FACTOR,BMP2_HUMAN,Induces cartilage and bone formation.,NONE,Bone disease;Musculoskeletal disease;Periodontal disease;Bone injury;Osteoporosis,,,,"
"
1fk0_v,3,2.838,0.9461,0.416097,3,0,0,0,0,0,Non-specific lipid-transfer protein,NONE,P19656,Involved in lipid binding,NONE,NONE,,,,"
"
3atj_v,3,2.837,0.9456,0.611843,1,1,1,0,0,0,Peroxidase C1A,NONE,P00433,Involved in peroxidase activity,NONE,NONE,,,,"
"
1mmy_v,3,2.831,0.9435,0.580686,1,1,1,0,0,0,NONE,NONE,NONE,NONE,NONE,NONE,,,,"
"
1qkq_v,3,2.83,0.9433,0.691311,0,1,2,0,0,0,Eosinophil lysophospholipase,SERINE ESTERASE,LPPL_HUMAN,May have both lysophospholipase and carbohydrate-binding activities.,"Forms hexagonal bipyramidal crystals, known as Charcot- Leyden crystals, in tissues and secretions from sites of eosinophil-associated inflammation and some myeloid leukemias.",NONE,,,,"
"
1e1x_v,3,2.823,0.941,0.590293,1,1,1,0,0,0,Cell division protein kinase 2,NONE,P24941,Involved in protein kinase activity,NONE,NONE,,,,"
"
1hxt_v,3,2.819,0.9395,0.457131,3,0,0,0,0,0,Outer membrane protein F,NONE,P02931,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1qy1_v,3,2.818,0.9393,0.00977522,3,0,0,0,0,0,Major urinary protein 1,NONE,P11588,Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.,NONE,NONE,,,,"
"
1g1q_v,3,2.816,0.9388,0.520553,1,1,1,0,0,0,P-selectin,"IMMUNE SYSTEM, MEMBRANE PROTEIN",LYAM3_HUMAN,Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of ,"Defects in SELP may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.",Sickle cell anemia;Inflammation;Transplant rejection;Myocardial infarction;Restenosis;Thrombosis,,,,"
"
1qjp_v,3,2.811,0.9371,0.330929,3,0,0,0,0,0,Outer membrane protein A,NONE,P0A910,Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes.,NONE,NONE,,,,"
"
1r5r_v,3,2.811,0.9371,0.499596,2,1,0,0,0,0,Odorant binding protein ASP1,NONE,Q8WRW5,Involved in odorant binding,NONE,NONE,,,,"
"
1nww_v,3,2.803,0.9345,0.429803,2,0,1,0,0,0,"Limonene-1,2-epoxide hydrolase",NONE,Q9ZAG3,"Involved in limonene-1,2-epoxide hydrolase activity",NONE,NONE,,,,"
"
1ad2_v,3,2.797,0.9325,0.0416295,3,0,0,0,0,0,50S ribosomal protein L1,NONE,P27150,Involved in RNA binding,NONE,NONE,,,,"
"
1suo_v,3,2.796,0.9322,0.516353,2,1,0,0,0,0,Cytochrome P450 2B4,OXIDOREDUCTASE,CP2B4_RABIT,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xe",NONE,NONE,,,,"
"
1yce_v,3,2.794,0.9315,0.0566187,3,0,0,0,0,0,"ATP synthase C chain, sodium ion specific",NONE,P21905,Energy production and conversion,NONE,NONE,,,,"
"
2vwu_v,3,2.793,0.9311,0.508936,2,1,0,0,0,0,Ephrin type-B receptor 4,TRANSFERASE,EPHB4_HUMAN,Receptor for members of the ephrin-B family. Binds to ephrin-B2. May have a role in events mediating differentiation and development.,NONE,Ocular disease;Rheumatoid arthritis;Cancer,,,,"
"
1l4n_v,3,2.782,0.9273,0.256998,1,1,1,0,0,0,Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase,NONE,A9MTA4,"Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).",NONE,NONE,,,,"
"
1rcj_v,4,3.709,0.9272,1.6144,1,3,0,0,0,0,Beta-lactamase SHV-1,NONE,P0AD64,NONE,NONE,NONE,,,,"
"
1w8m_v,3,2.779,0.9262,0.315458,1,2,0,0,0,0,Peptidyl-prolyl cis-trans isomerase A,NONE,P62937,"Posttranslational modification, protein turnover, chaperones",NONE,"For treatment of transplant rejection, rheumatoid arthritis, severe psoriasis",,,,"
"
2ovm_v,3,2.766,0.9222,0.486504,2,1,0,0,0,0,Progesterone receptor,TRANSCRIPTION,PRGR_HUMAN,The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.,NONE,Uterine fibroids;Menstruation disorder;Infertility;Acne;Breast tumor;Female contraception;Neoplasm;Planned abortion;Dysmenorrhea;Endometriosis;Hormone deficiency;Unidentified indication;Gynecological disorder;Musculoskeletal disease;Estrogen deficiency;Cancer;Contraception;Amenorrhea;Female infertility;Carcinoma;Menopause;Premenstrual syndrome;Anesthesia;Age related macular degeneration;Osteoporosis,,,,"
"
1pwp_v,3,2.765,0.9217,0.204612,3,0,0,0,0,0,Lethal factor,NONE,P15917,Involved in protease activity,NONE,NONE,,,,"
"
1ylv_v,3,2.764,0.9215,0.228844,1,2,0,0,0,0,Delta-aminolevulinic acid dehydratase,NONE,P05373,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1ufy_v,3,2.762,0.9206,0.264722,1,2,0,0,0,0,Chorismate mutase,NONE,Q84FH6,Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.,NONE,NONE,,,,"
"
1p49_v,3,2.761,0.9204,0.165927,3,0,0,0,0,0,Steryl-sulfatase,HYDROLASE,STS_HUMAN,Conversion of sulfated steroid precursors to estrogens during pregnancy.,"Defects in STS are the cause of ichthyosis X-linked (IXL) [MIM:308100]. Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.",Cognitive disorder;Cancer;Breast tumor,,,,"
"
1jdz_v,3,2.756,0.9187,0.341092,0,2,1,0,0,0,S-methyl-5-thioadenosine phosphorylase,NONE,P50389,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1nx3_v,3,2.747,0.9156,0.206394,2,1,0,0,0,0,Calpain small subunit 1,NONE,P04574,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1yb1_v,3,2.738,0.9128,0.242555,2,0,1,0,0,0,Estradiol 17-beta-dehydrogenase 11,OXIDOREDUCTASE,DHB11_HUMAN,"Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating ",NONE,Prostate tumor,,,,"
"
1upf_v,3,2.738,0.9127,0.44054,0,2,1,0,0,0,Uracil phosphoribosyltransferase,TRANSFERASE,UPP_TOXGO,NONE,NONE,NONE,,,,"
"
2ohp_v,3,2.737,0.9123,0.348859,2,0,1,0,0,0,Beta-secretase 1,HYDROLASE,BACE1_HUMAN,"Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP",NONE,Alzheimers disease,,,,"
"
1tg8_v,3,2.736,0.912,0.257915,0,3,0,0,0,0,Genome polyprotein,NONE,P27914,"Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).",NONE,NONE,,,,"
"
1n2f_v,3,2.731,0.9104,0.457935,0,2,1,0,0,0,Organic hydroperoxide resistance protein,NONE,Q9HZZ3,"Posttranslational modification, protein turnover, chaperones",NONE,NONE,,,,"
"
1cr6_v,3,2.725,0.9084,0.142241,3,0,0,0,0,0,Epoxide hydrolase 2,NONE,P34914,Involved in hydrolase activity,NONE,NONE,,,,"
"
2pin_v,3,2.721,0.9069,-0.0767677,3,0,0,0,0,0,Thyroid hormone receptor beta,NONE,P10828,"Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.",NONE,NONE,,,,"
"
1w1l_v,3,2.72,0.9068,0.329167,2,1,0,0,0,0,Vanillyl-alcohol oxidase,NONE,P56216,Energy production and conversion,NONE,NONE,,,,"
"
1q9b_v,3,2.719,0.9063,0.39945,1,2,0,0,0,0,Pro-hevein,NONE,P02877,N-acetyl-D-glucosamine / N-acetyl-D-neuraminic acid binding lectin. Can inhibit fungal growth.,NONE,NONE,,,,"
"
1l6l_v,3,2.718,0.9059,0.103414,3,0,0,0,0,0,Apolipoprotein A-II,LIPID TRANSPORT,APOA2_HUMAN,"May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.",NONE,NONE,,,,"
"
1ctt_v,3,2.714,0.9047,0.3799,1,2,0,0,0,0,Cytidine deaminase,NONE,P0ABF6,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1nqh_v,3,2.708,0.9028,0.124275,3,0,0,0,0,0,Vitamin B12 transporter btuB,NONE,P06129,Coenzyme transport and metabolism,NONE,For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.,,,,"
"
1kwc_v,3,2.707,0.9022,0.292304,2,0,1,0,0,0,"Biphenyl-2,3-diol 1,2-dioxygenase",NONE,P17297,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1ea1_v,3,2.704,0.9013,0.158775,3,0,0,0,0,0,Cytochrome P450 51,OXIDOREDUCTASE,CP51_MYCTU,"Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4-dimethyl cholesta-8,14,24-triene- 3-beta-o",NONE,NONE,,,,"
"
1jv7_v,3,2.701,0.9003,-0.0711418,3,0,0,0,0,0,Bacteriorhodopsin,NONE,P02945,Involved in ion channel activity,NONE,NONE,,,,"
"
1qd5_v,3,2.695,0.8983,-0.0804614,3,0,0,0,0,0,Phospholipase A1,NONE,P0A921,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1try_v,3,2.693,0.8976,0.366502,1,2,0,0,0,0,Trypsin,NONE,P35049,Involved in protease activity,NONE,NONE,,,,"
"
1udx_v,3,2.689,0.8962,0.368104,2,0,1,0,0,0,Hypothetical protein,NONE,Q7X493,Involved in GTP binding,NONE,NONE,,,,"
"
1xhb_v,3,2.678,0.8927,0.319143,0,2,1,0,0,0,Polypeptide N-acetylgalactosaminyltransferase 1,NONE,O08912,"Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7",NONE,NONE,,,,"
"
1w6f_v,3,2.678,0.8926,0.22929,1,2,0,0,0,0,Arylamine N-acetyltransferase,TRANSFERASE,NAT_MYCSM,"Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid.",NONE,NONE,,,,"
"
1sv3_v,3,2.678,0.8925,0.0599867,1,2,0,0,0,0,Phospholipase A2 VRV-PL-VIIIa,NONE,P59071,Involved in phospholipase A2 activity,NONE,For the treatment of tuberculosis,,,,"
"
1ke3_v,4,3.564,0.8909,2.38814,2,2,0,0,0,0,Beta-lactamase,HYDROLASE,AMPC_ECOLI,This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.,NONE,NONE,,,,"
"
1v3q_v,3,2.672,0.8906,0.165697,1,2,0,0,0,0,Purine nucleoside phosphorylase,TRANSFERASE,PNPH_HUMAN,NONE,Defects in NP are the cause of nucleoside phosphorylase deficiency (NP deficiency) [MIM:164050]. It leads to a severe T- cell immunodeficiency with neurologic disorder in children.,T-cell lymphoma;Autoimmune disease;HIV infection;Dermatitis;Chronic lymphocytic leukemia;Acquired Immune Deficiency Syndrome;Inflammation;Multiple sclerosis;Solid tumor;Psoriasis;Non-Hodgkin lymphoma;Viral infection;Cancer;Rheumatoid arthritis;Leukemia;B-cell acute lymphoblastic leukemia;Cutaneous T-cell lymphoma;Ocular disease;Transplant rejection;Immune disorder,,,,"
"
1dzk_v,3,2.67,0.8899,-0.62935,3,0,0,0,0,0,Odorant-binding protein,NONE,P81245,This protein is found in nasal epithelium and it binds a wide variety of chemical odorants.,NONE,NONE,,,,"
"
1apm_v,3,2.667,0.889,0.0848838,3,0,0,0,0,0,cAMP-dependent protein kinase catalytic subunit alpha,NONE,P05132,Involved in protein serine/threonine kinase activity,NONE,NONE,,,,"
"
2g01_v,4,3.551,0.8878,2.41122,3,1,0,0,0,0,Mitogen-activated protein kinase 8,TRANSFERASE,MK08_HUMAN,"Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1;JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta- 2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, ",NONE,Psoriasis;Asthma;Cancer;Neurodegenerative disease;Inflammation;Liver disease;Acute myelogenous leukemia;Diabetes mellitus;Pulmonary fibrosis;Ischemia,,,,"
"
1ems_v,3,2.66,0.8868,-0.410988,3,0,0,0,0,0,Nitrilase and fragile histidine triad fusion protein NitFhit [Includes: Bis(5-adenosyl)-triphosphatase,NONE,O76463,"Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds",NONE,NONE,,,,"
"
1dlt_v,3,2.659,0.8864,-0.133692,1,0,2,0,0,0,"Catechol 1,2-dioxygenase",NONE,P07773,"Secondary metabolites biosynthesis, transport and catabolism",NONE,NONE,,,,"
"
1ji5_v,3,2.654,0.8848,-0.220087,3,0,0,0,0,0,DNA protection during starvation protein 2,NONE,Q8RPQ2,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1pr0_v,3,2.652,0.8839,0.3357,0,1,2,0,0,0,Purine nucleoside phosphorylase deoD-type,TRANSFERASE,DEOD_ECOLI,Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules.,NONE,NONE,,,,"
"
1e7e_v,3,2.65,0.8832,-0.0733869,3,0,0,0,0,0,Serum albumin,PLASMA PROTEIN,ALBU_HUMAN,"Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.",Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.;A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood [MIM:194470].,NONE,,,,"
"
1sed_v,3,2.639,0.8797,-0.37701,3,0,0,0,0,0,Hypothetical protein yhaI,NONE,O07517,NONE,NONE,NONE,,,,"
"
1ygp_v,3,2.637,0.8791,0.0826453,2,1,0,0,0,0,Glycogen phosphorylase,NONE,P06738,"Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.",NONE,NONE,,,,"
"
2be1_v,3,2.627,0.8758,-0.565982,3,0,0,0,0,0,Serine/threonine-protein kinase/endoribonuclease IRE1,NONE,P32361,Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes.,NONE,NONE,,,,"
"
1muo_v,3,2.627,0.8756,0.122615,0,2,1,0,0,0,Serine/threonine-protein kinase 6,TRANSFERASE,STK6_HUMAN,"May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. May be involved in microtubule formation and/or stabilization. May play a key role ",Defects in AURKA are responsible for numerical centrosome aberrations including aneuploidy.,Pancreas tumor;Cancer;Solid tumor,,,,"
"
2pio_v,3,2.615,0.8716,0.0768337,2,0,1,0,0,0,Androgen receptor,HORMONE RECEPTOR,ANDR_HUMAN,Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and core,"Genetic variation in AR can be responsible of androgenetic alopecia (AGA) [MIM:109200].;Defects in AR are the cause of androgen insensibility syndrome (AIS) [MIM:300068]; previously known as testicular feminization syndrome (TFM). It can be complete (CAIS) when external genitalia are phenotypically female; or partial (PAIS) when external genitalia are substantively ambiguous or mild (MAIS) when external genitalia are normal male or nearly so.;Defects in AR are the cause of X-linked spinal and bulbar muscular atrophy (SBMA) [MIM:313200]; also known as Kennedy disease. In SBMA patients the number of Gln ranges from 40 to 52. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.;Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor.;Defects in AR may be the cause of infertility male syndrome [MIM:308370]; also called androgen insensitivity. It is characterized by azoospermia, elevated testosterone and luteinizing hormone plasma levels and an abnormal androgen receptor.;Defects in AR are the cause of Reifenstein syndrome [MIM:312300]; also known as partial androgen insensitivity. The features of this form of male pseudohermaphroditism are hypospadias, hypogonadism, gynecomastia, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance.",Hypoactive sexual desire disorder;Hepatitis B virus infection;Cardiac failure;Andrology;Hirsutism;Female sexual dysfunction;Psoriasis;Reperfusion injury;Plasmodium infection;Atherosclerosis;Prostate hyperplasia;Fatigue;Male sexual dysfunction;Autoimmune disease;Testosterone deficiency;Uterine fibroids;Metabolic disorder;Myalgia;Obesity;Gynecological disorder;Contraception;Cancer;Hypercholesterolemia;Skin burns;Seborrhea;Growth disorder;Bone tumor;Muscular dystrophy;Erectile dysfunction;Systemic lupus erythematosus;Asthma;Wound healing;Cerebrovascular ischemia;Acne;Hypogonadism;HIV infection;Neoplasm;Dermatological disease;Prostate disease;Multiple sclerosis;Lacrimal gland disease;Alopecia;Mycobacterium tuberculosis infection;Ovary cyst;Carcinoma;Cardiovascular disease;Cachexia;Muscle wasting disease;Cervical dystonia;Anemia;Endocrine disease;Non-insulin dependent diabetes;Breast tumor;Female contraception;Fungal infection;Cystic fibrosis;Prostate tumor;Estrogen deficiency;Endometriosis;Hormone deficiency;Turners syndrome;Keratosis;Premenstrual syndrome;Hepatitis C virus infection;Benign tumor;Osteoporosis;Male contraception,,,,"
"
1kmp_v,4,3.485,0.8713,1.63681,4,0,0,0,0,0,Fe(3+) dicitrate transport protein fecA,NONE,P13036,Inorganic ion transport and metabolism,NONE,NONE,,,,"
"
3bto_v,3,2.614,0.8713,-0.254434,2,1,0,0,0,0,Alcohol dehydrogenase E chain,NONE,P00327,Energy production and conversion,NONE,For the symptomatic relief of patients with interstitial cystitis.,,,,"
"
1jip_v,3,2.613,0.871,-0.0914943,2,1,0,0,0,0,6-deoxyerythronolide B hydroxylase,NONE,Q00441,"Secondary metabolites biosynthesis, transport and catabolism",NONE,NONE,,,,"
"
1llp_v,3,2.606,0.8687,0.11998,0,2,1,0,0,0,Ligninase LG2,NONE,P49012,Involved in peroxidase activity,NONE,NONE,,,,"
"
1k59_v,4,3.473,0.8683,2.59754,0,4,0,0,0,0,Angiogenin,HYDROLASE,ANGI_HUMAN,"May function as a tRNA-specific ribonuclease that binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, thereby promoting the endothelial invasiveness necessary for blood vessel formatio","Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.",NONE,,,,"
"
1jgj_v,3,2.602,0.8673,-0.111728,3,0,0,0,0,0,Sensory rhodopsin-2,NONE,P42196,Involved in ion channel activity,NONE,NONE,,,,"
"
1aho_v,3,2.602,0.8672,0.163945,2,1,0,0,0,0,Neurotoxin 2,NONE,P01484,Involved in sodium channel inhibitor activity,NONE,NONE,,,,"
"
1f8y_v,3,2.588,0.8627,0.219104,0,2,1,0,0,0,Nucleoside deoxyribosyltransferase,NONE,Q9R5V5,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1eq9_v,3,2.57,0.8566,-0.195144,1,2,0,0,0,0,Chymotrypsin-1,NONE,Q7SIG2,Involved in catalytic activity,NONE,NONE,,,,"
"
2itx_v,3,2.567,0.8558,0.00757657,0,2,1,0,0,0,Epidermal growth factor receptor,TRANSFERASE,EGFR_HUMAN,"Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phospho;Isoform 2/truncated isoform may act as an antagonist.",Defects in EGFR are associated with lung cancer [MIM:211980].,Squamous cell carcinoma;Arteriosclerosis;Melanoma;Central nervous system tumor;Diabetes mellitus;Esophagus tumor;Ischemic heart disease;Brain tumor;Nasopharyngeal carcinoma;Liver tumor;Pancreas tumor;Lung tumor;Psoriasis;Bladder tumor;Esophageal disease;Mesothelioma;Atherosclerosis;Multiple myeloma;Bacterial infection;Uterine cervix tumor;Nasopharynx tumor;Carcinoma;Restenosis;Stomach tumor;Thyroid tumor;Small-cell lung cancer;Renal disease;Nervous system tumor;Hepatobiliary system tumor;Breast tumor;Head and neck tumor;Ovary tumor;Prostate tumor;Renal tumor;Solid tumor;Colon tumor;Glioma;Cancer;Non-small-cell lung cancer;Metastasis;Renal cell carcinoma;Glioblastoma;Colorectal tumor;Neoplasm;Sarcoma;Hypercholesterolemia,,,,"
"
1wz8_v,3,2.565,0.8549,0.142107,1,0,2,0,0,0,Enoyl-CoA hydratase,NONE,Q5SLS5,Involved in catalytic activity,NONE,NONE,,,,"
"
1iy8_v,3,2.563,0.8545,0.0778991,2,0,1,0,0,0,Levodione reductase,NONE,Q9LBG2,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
2b3k_v,3,2.554,0.8514,0.0519421,0,2,1,0,0,0,Methionine aminopeptidase 1,HYDROLASE,AMPM1_HUMAN,Removes the amino-terminal methionine from nascent proteins (By similarity).,NONE,NONE,,,,"
"
1z68_v,3,2.551,0.8504,-0.0396537,0,2,1,0,0,0,Seprase,LYASE,SEPR_HUMAN,"May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.",NONE,Non-Hodgkin lymphoma;Melanoma;Cancer;Non-small-cell lung cancer;Chronic lymphocytic leukemia;Neutropenia;Pancreas tumor;Hematological disease;Renal tumor,,,,"
"
1ioa_v,4,3.401,0.8502,2.05205,0,2,2,0,0,0,Arcelin-5A,NONE,Q42460,Involved in sugar binding,NONE,NONE,,,,"
"
2pil_v,3,2.528,0.8426,0.0260515,0,3,0,0,0,0,Fimbrial protein,NONE,P02974,Cell motility,NONE,NONE,,,,"
"
1usq_v,3,2.507,0.8356,-0.592301,2,1,0,0,0,0,Dr hemagglutinin structural subunit,NONE,P24093,Involved in protein binding,NONE,"Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.",,,,"
"
1wbu_v,3,2.496,0.832,0.10181,0,2,1,0,0,0,Ribonuclease pancreatic,NONE,P61823,Involved in nucleic acid binding,NONE,"There is no support for the claim that aspartates are exercise performance enhancers, i.e. ergogenic aids.",,,,"
"
2gg3_v,3,2.494,0.8313,-0.0298909,2,0,1,0,0,0,Methionine aminopeptidase,NONE,P0AE18,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
1fp2_v,3,2.493,0.831,-0.183347,2,0,1,0,0,0,Isoflavone-7-O-methyltransferase 8,NONE,O24529,"Secondary metabolites biosynthesis, transport and catabolism",NONE,NONE,,,,"
"
2uzd_v,3,2.492,0.8306,-0.0780906,2,1,0,0,0,0,Cyclin-A2,TRANSFERASE,CCNA2_HUMAN,Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.,NONE,NONE,,,,"
"
1xlv_v,3,2.482,0.8272,-0.0814985,1,2,0,0,0,0,Cholinesterase,HYDROLASE,CHLE_HUMAN,NONE,"Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.","Neurotoxicity, drug-induced;Toxicity;Alzheimers disease",,,,"
"
2a2g_v,3,2.478,0.826,-0.525124,3,0,0,0,0,0,Major urinary protein,NONE,P02761,Involved in phermone binding,NONE,NONE,,,,"
"
1y9l_v,4,3.3,0.8249,1.2975,4,0,0,0,0,0,Lipoprotein mxiM,NONE,P0A1X2,Involved in the secretion of the Ipa antigens.,NONE,NONE,,,,"
"
1jim_v,3,2.472,0.8242,-0.259875,1,2,0,0,0,0,Chymotrypsin-like elastase family member 1,NONE,P00772,Involved in protease activity,NONE,NONE,,,,"
"
1lrt_v,4,3.288,0.8221,1.73952,2,1,1,0,0,0,Inosine-5-monophosphate dehydrogenase,NONE,P50097,Nucleotide transport and metabolism,NONE,"For the prophylaxis of organ rejection in patients receiving allogeneic renal transplants, administered in combination with cyclosporine and corticosteroids.",,,,"
"
1p3h_v,3,2.466,0.8219,-0.162756,2,1,0,0,0,0,10 kDa chaperonin,NONE,P09621,Involved in ATP binding,NONE,NONE,,,,"
"
2p2h_v,4,3.282,0.8205,1.6224,2,1,1,0,0,0,Vascular endothelial growth factor receptor 2,TRANSFERASE,VGFR2_HUMAN,"Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extrace",NONE,Angiogenesis disorder;Melanoma;Cancer;Non-small-cell lung cancer;Renal cell carcinoma;Colorectal tumor;Ocular disease;Age related macular degeneration;Solid tumor,,,,"
"
1ogs_v,3,2.458,0.8195,-0.416662,0,3,0,0,0,0,Glucosylceramidase,HYDROLASE,GLCM_HUMAN,NONE,"Defects in GBA are the cause of Gaucher disease (GD) [MIM:230800]; also known as glucocerebrosidase deficiency. GD is the most prevalent lysosomal storage disease, characterized by accumulation of glucosylceramide in the reticulo-endothelial system. Different clinical forms are recognized depending on the presence (neuronopathic forms) or absence of central nervous system involvement, severity and age of onset.;Defects in GBA are the cause of Gaucher disease type 1 (GD1) [MIM:230800]; also known as adult non-neuronopathic Gaucher disease. GD1 is characterized by hepatosplenomegaly with consequent anemia and thrombopenia, and bone involvement. The central nervous system is not involved.;Defects in GBA are the cause of Gaucher disease type 2 (GD2) [MIM:230900]; also known as acute neuronopathic. GD2 is the most severe form and is universally progressive and fatal. It manifests soon after birth, with death generally occurring before patients reach two years of age.;Defects in GBA are the cause of Gaucher disease type 3 (GD3) [MIM:231000]; also known as subacute neuronopathic. GD3 has central nervous manifestations.;Defects in GBA are the cause of Gaucher disease type 3C [MIM:231005]; also known as pseudo-Gaucher disease or Gaucher-like disease.;Defects in GBA are the cause of perinatal lethal Gaucher disease [MIM:608013]. It is a distinct form of Gaucher disease type 2, characterized by fetal onset. Hydrops fetalis, in utero fetal death and neonatal distress are prominent features. When hydrops is absent, neurologic involvement begins in the first week and leads to death within 3 months. Hepatosplenomegaly is a major sign, and is associated with ichthyosis, arthrogryposis, and facial dysmorphism.;Perinatal lethal Gaucher disease is associated with non- immune hydrops fetalis [MIM:236750]. Hydrops fetalis is a generalized edema of the fetus with fluid accumulation in the body cavities.;Defects in GBA may be a risk factor in the development of Parkinson disease (PD) [MIM:168600]. Simultaneous occurrence of Parkinson disease and Gaucher disease is marked by atypical parkinsonism generally presenting by the fourth through sixth decades of life. The combination progresses inexorably and is refractory to conventional anti-Parkinson therapy.",Gaucher disease,,,,"
"
2mcm_v,3,2.45,0.8166,-0.257724,1,0,2,0,0,0,Macromomycin,NONE,P01549,Involved in DNA binding,NONE,NONE,,,,"
"
1o5m_v,3,2.448,0.816,-0.60668,3,0,0,0,0,0,Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha,NONE,Q04631,Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.,NONE,NONE,,,,"
"
1y5m_v,3,2.443,0.8143,-0.485104,3,0,0,0,0,0,Corticosteroid 11-beta-dehydrogenase isozyme 1,NONE,P50172,Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.,NONE,NONE,,,,"
"
1fdu_v,4,3.252,0.8131,1.47565,3,0,1,0,0,0,Estradiol 17-beta-dehydrogenase 1,NONE,P14061,Lipid transport and metabolism,NONE,"Some evidence suggests that NADH might be useful in treating Parkinsons disease, chronic fatigue syndrome, Alzheimers disease and cardiovascular disease.",,,,"
"
1q9h_v,3,2.431,0.8102,-0.324808,0,2,1,0,0,0,Cellobiohydrolase I catalytic domain,NONE,Q8TFL9,"Involved in hydrolase activity, hydrolyzing O-glycosyl compounds",NONE,NONE,,,,"
"
3pax_v,4,3.236,0.8089,1.44328,1,2,1,0,0,0,Poly [ADP-ribose] polymerase 1,NONE,P26446,Involved in DNA binding,NONE,NONE,,,,"
"
1xn0_v,3,2.42,0.8068,-0.371288,0,2,1,0,0,0,"cAMP-specific 3,5-cyclic phosphodiesterase 4B",HYDROLASE,PDE4B_HUMAN,May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.,NONE,Chronic obstructive pulmonary disease;Asthma,,,,"
"
1ung_v,3,2.402,0.8007,-0.126944,1,1,1,0,0,0,Cyclin-dependent kinase 5 activator 1,COMPLEX(KINASE/ACTIVATOR),CD5R1_HUMAN,p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Activator of TPKII.,"Cleavage of p35 to p25 may be involved in the pathogenesis of Alzheimer disease. The p25 form accumulates in neurons in the brain of patients with Alzheimer disease, but not in normal brain. This accumulation correlates with an increase in CDK5 kinase activity. Application of amyloid beta peptide A- beta(1-42) induced the conversion of p35 to p25 in primary cortical neurons. Expression of the p25/Cdk5 complex in cultured primary neurons induces cytoskeletal disruption, morphological degeneration and apoptosis.",Neurodegenerative disease,,,,"
"
1pmv_v,3,2.4,0.8001,-1.59671,2,1,0,0,0,0,Mitogen-activated protein kinase 10,TRANSFERASE,MK10_HUMAN,"Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-",A chromosomal rearrangement involving MAPK10 is a cause of epileptic encephalopathy Lennox-Gastaut type [MIM:606369]. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures.,Central nervous system disease;Inflammation;Pulmonary fibrosis;Ischemia;Cerebrovascular ischemia;Neurodegenerative disease,,,,"
"
1jwk_v,4,3.176,0.794,1.00945,3,1,0,0,0,0,"Nitric oxide synthase, inducible",NONE,P29477,Inorganic ion transport and metabolism,NONE,NONE,,,,"
"
3dej_v,3,2.382,0.794,-0.565143,2,1,0,0,0,0,Caspase-3,"HYDROLASE, APOPTOSIS",CASP3_HUMAN,Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp-,-Gly-217 bond. Cleaves and activates sterol regulatory element bind,NONE,Cancer;Liver disease;Cognitive disorder;Neurodegenerative disease;Cerebrovascular ischemia,,,"
"
1fj4_v,5,3.963,0.7925,0.851294,3,2,0,0,0,0,3-oxoacyl-[acyl-carrier-protein] synthase 1,NONE,P0A953,Lipid transport and metabolism,NONE,"For use as a biochemical tool, Cerulenin is shown to cause dramatic weight loss in animals",,,,"
"
1mup_v,3,2.377,0.7924,-1.56026,3,0,0,0,0,0,Major urinary protein 6,NONE,P02762,Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.,NONE,NONE,,,,"
"
1lmo_v,3,2.375,0.7915,-0.207165,0,1,2,0,0,0,Lysozyme C II,NONE,P11941,Involved in lysozyme activity,NONE,NONE,,,,"
"
4thi_v,3,2.373,0.791,-0.384283,2,0,1,0,0,0,Thiaminase-1,NONE,P45741,Degrades thiamine by replacing its thiazole moiety with a wide range of nucleophiles.,NONE,NONE,,,,"
"
1geb_v,4,3.155,0.7888,1.29156,3,1,0,0,0,0,Camphor 5-monooxygenase,NONE,P00183,"Secondary metabolites biosynthesis, transport and catabolism",NONE,For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.,,,,"
"
1uyq_v,3,2.365,0.7882,-0.0548436,1,0,2,0,0,0,Beta-glucosidase A,NONE,P22073,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1iwi_v,4,3.148,0.787,1.15811,3,1,0,0,0,0,Cytochrome P450-cam,NONE,P00183,"Secondary metabolites biosynthesis, transport and catabolism",NONE,For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.,,,,"
"
2c47_v,4,3.144,0.786,1.3331,1,1,2,0,0,0,Casein kinase I isoform gamma-2,TRANSFERASE,KC1G2_HUMAN,Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).,NONE,NONE,,,,"
"
1s1m_v,4,3.132,0.7831,1.09712,3,0,1,0,0,0,CTP synthase,NONE,P0A7E8,Involved in catalytic activity,NONE,NONE,,,,"
"
1y6w_v,3,2.338,0.7793,-0.553851,1,0,2,0,0,0,Calmodulin,CALCIUM-BINDING PROTEIN,CALM_HUMAN,"Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved ",NONE,NONE,,,,"
"
1yk7_v,5,3.87,0.7739,3.49545,2,3,0,0,0,0,Cathepsin K,HYDROLASE,CATK_HUMAN,Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.,Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.,Multiple sclerosis;Asthma;Cancer;Rheumatoid arthritis;Autoimmune disease;Arthritis;Bacterial infection;Bone disease;Osteoarthritis;Bone metastases;Immune disorder;Osteoporosis,,,,"
"
1q8m_v,3,2.314,0.7714,-0.495211,1,2,0,0,0,0,Triggering receptor expressed on myeloid cells 1,NONE,Q9NP99,Involved in immune triggering activity,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1kou_v,4,3.084,0.7711,1.1911,1,1,2,0,0,0,Photoactive yellow protein,NONE,P16113,Involved in signal transducer activity,NONE,NONE,,,,"
"
1z2u_v,3,2.312,0.7707,-0.583181,1,1,1,0,0,0,Ubiquitin-conjugating enzyme E2 2,NONE,P35129,Involved in small conjugating protein ligase activity,NONE,NONE,,,,"
"
1qgj_v,3,2.311,0.7702,-0.344245,0,1,2,0,0,0,Peroxidase 59,NONE,Q39034,Involved in peroxidase activity,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1x97_v,3,2.31,0.7699,-0.422627,2,1,0,0,0,0,Aldose reductase,OXIDOREDUCTASE,ALDR_HUMAN,Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.,"In diabetes and galactosemia, increased AR activity leads to high levels of sorbitol and galactitol, respectively, in the cells of many tissues. Accumulation of sugar alcohols has been shown to cause osmotic cataracts in the lens. AR is also thought to play a key role in diabetic complications of three other target tissues, namely, nerve, kidney and retina.",Neuropathy;Diabetic neuropathy;Diabetic foot ulcer;Diabetic complication;Diabetic nephropathy;Retinopathy;Ocular disease;Central nervous system disease;Diabetic retinopathy;Diabetes mellitus;Diabetic cataract;Cataract,,,,"
"
1j4n_v,4,3.061,0.7651,0.775157,3,1,0,0,0,0,Aquaporin-1,NONE,P47865,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
2pe0_v,4,3.058,0.7646,0.980011,3,1,0,0,0,0,3-phosphoinositide-dependent protein kinase 1,TRANSFERASE,PDPK1_HUMAN,"Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.",NONE,NONE,,,,"
"
1gqh_v,3,2.282,0.7605,-0.826033,0,1,2,0,0,0,"Quercetin 2,3-dioxygenase",NONE,Q7SIC2,"Involved in quercetin 2,3-dioxygenase activity",NONE,NONE,,,,"
"
1m9j_v,4,3.032,0.7581,0.753796,2,1,1,0,0,0,"Nitric oxide synthase, endothelial",OXIDOREDUCTASE,NOS3_HUMAN,Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clot,NONE,Coronary artery disease;Hypertension;Congestive heart failure;Angina;Myocardial infarction;Peripheral vascular disease;Atherosclerosis;Ischemic heart disease,,,,"
"
2w70_v,3,2.272,0.7574,-0.628109,2,0,1,0,0,0,Biotin carboxylase,NONE,P24182,"This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.",NONE,NONE,,,,"
"
1fyd_v,5,3.782,0.7564,1.62579,0,3,2,0,0,0,NH(3)-dependent NAD(+) synthetase,NONE,P08164,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1tve_v,4,3.008,0.752,0.661451,3,0,1,0,0,0,Homoserine dehydrogenase,NONE,P31116,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1xl1_v,5,3.757,0.7513,2.38633,1,1,3,0,0,0,"Glycogen phosphorylase, muscle form",NONE,P11217,Carbohydrate transport and metabolism,NONE,For nutritional supplementation and for treating dietary shortage or imbalance.,,,,"
"
1puo_v,4,2.997,0.7492,0.778485,3,0,1,0,0,0,Major allergen I polypeptide chain 2,NONE,P30440,NONE,NONE,NONE,,,,"
"
3eqm_v,3,2.247,0.749,-0.858125,2,1,0,0,0,0,Cytochrome P450 19A1,NONE,P11511,Catalyzes the formation of aromatic C18 estrogens from C19 androgens.,NONE,NONE,,,,"
"
1vbk_v,4,2.996,0.7489,0.56702,3,1,0,0,0,0,Hypothetical protein PH1313,NONE,O59053,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1vk6_v,4,2.995,0.7488,0.594766,3,1,0,0,0,0,NADH pyrophosphatase,NONE,P32664,Involved in hydrolase activity,NONE,NONE,,,,"
"
1utl_v,4,2.995,0.7487,0.604441,3,1,0,0,0,0,Trypsin-1,NONE,P35031,Involved in protease activity,NONE,NONE,,,,"
"
1ov4_v,5,3.741,0.7482,1.65514,4,1,0,0,0,0,Bile salt sulfotransferase,NONE,Q06520,Involved in sulfotransferase activity,NONE,NONE,,,,"
"
1l6m_v,4,2.993,0.7482,0.589501,1,1,1,0,1,0,Neutrophil gelatinase-associated lipocalin,TRANSPORT PROTEIN,NGAL_HUMAN,Transport of small lipophilic substances (Potential).,NONE,NONE,,,,"
"
1g0o_v,5,3.727,0.7455,1.16895,2,2,0,0,0,1,Tetrahydroxynaphthalene reductase,NONE,Q12634,Lipid transport and metabolism,NONE,NONE,,,,"
"
1xpj_v,4,2.982,0.7454,0.803809,0,3,1,0,0,0,Hypothetical protein VC0232,NONE,Q9KVB4,NONE,NONE,NONE,,,,"
"
1lnm_v,4,2.981,0.7452,0.0339491,4,0,0,0,0,0,Bilin-binding protein,LIGAND BINDING PROTEIN,BBP_PIEBR,This protein binds the blue pigments bilins.,NONE,NONE,,,,"
"
1l8s_v,4,2.979,0.7447,-0.13623,4,0,0,0,0,0,"Phospholipase A2, major isoenzyme",NONE,P00592,Involved in phospholipase A2 activity,NONE,NONE,,,,"
"
1jn2_v,4,2.977,0.7443,0.399333,2,1,0,0,1,0,Concanavalin-A,NONE,P02866,D-mannose specific lectin.,NONE,NONE,,,,"
"
1j78_v,4,2.974,0.7435,-0.138405,4,0,0,0,0,0,Vitamin D-binding protein,"TRANSPORT, LIGAND BINDING PROTEIN",VTDB_HUMAN,"Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with mem",NONE,NONE,,,,"
"
1jx0_v,3,2.228,0.7428,-1.06722,2,1,0,0,0,0,Chalcone--flavonone isomerase 1,NONE,P28012,Involved in chalcone isomerase activity,NONE,NONE,,,,"
"
1lk9_v,4,2.97,0.7425,0.725611,0,3,0,0,1,0,Alliin lyase 1,NONE,Q01594,Involved in carbon-sulfur lyase activity,NONE,NONE,,,,"
"
1f4d_v,4,2.965,0.7411,0.451273,3,1,0,0,0,0,Thymidylate synthase,NONE,P0A884,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1lv0_v,4,2.964,0.7411,-0.175248,4,0,0,0,0,0,Rab GDP dissociation inhibitor alpha,NONE,P21856,Involved in Rab GDP-dissociation inhibitor activity,NONE,NONE,,,,"
"
1yrs_v,5,3.704,0.7408,2.84095,3,0,2,0,0,0,Kinesin-like protein KIF11,CELL CYCLE,KIF11_HUMAN,Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.,NONE,Melanoma;Hodgkins disease;Acute leukemia;Breast tumor;Head and neck tumor;Hepatocellular carcinoma;Ovary tumor;Prostate tumor;Solid tumor;Non-Hodgkin lymphoma;Cancer;Non-small-cell lung cancer;Renal cell carcinoma;Colorectal tumor,,,,"
"
4pah_v,4,2.961,0.7402,0.753674,1,0,2,1,0,0,Phenylalanine-4-hydroxylase,MONOOXGYGENASE,PH4H_HUMAN,NONE,"Defects in PAH are the cause of phenylketonuria (PKU) [MIM:261600]. PKU is an autosomal recessive inborn error of phenylalanine metabolism, due to severe phenylalanine hydroxylase deficiency. It is characterized by blood concentrations of phenylalanine persistently above 1200 mumol (normal concentration 100 mumol) which usually causes mental retardation (unless low phenylalanine diet is introduced early in life). They tend to have light pigmentation, rashes similar to eczema, epilepsy, extreme hyperactivity, psychotic states and an unpleasant mousy odor.;Defects in PAH are the cause of non-phenylketonuria hyperphenylalaninemia (Non-PKU HPA) [MIM:261600]. Non-PKU HPA is a mild form of phenylalanine hydroxylase deficiency characterized by phenylalanine levels persistently below 600 mumol, which allows normal intellectual and behavioral development without treatment. Non-PKU HPA is usually caused by the combined effect of a mild hyperphenylalaninemia mutation and a severe one.;Defects in PAH are the cause of hyperphenylalaninemia (HPA) [MIM:261600]. HPA is the mildest form of phenylalanine hydroxylase deficiency.",Phenylketonuria;Sickle cell anemia;Vascular disease;Genetic disorder;Diabetic nephropathy;Hypertension;Ataxia;Peripheral arterial occlusive disease;Coronary artery disease,,,,"
"
1zs0_v,4,2.959,0.7396,0.794592,2,1,0,0,0,1,Neutrophil collagenase,HYDROLASE,MMP8_HUMAN,"Can degrade fibrillar type I, II, and III collagens.",NONE,NONE,,,,"
"
1f7t_v,3,2.219,0.7395,-1.40724,0,2,1,0,0,0,Holo-[acyl-carrier-protein] synthase,NONE,P96618,Lipid transport and metabolism,NONE,NONE,,,,"
"
1q8d_v,4,2.954,0.7385,0.516962,3,0,1,0,0,0,GDNF family receptor alpha-1,NONE,Q62997,Involved in receptor activity,NONE,NONE,,,,"
"
1uyn_v,4,2.952,0.7381,-0.18203,4,0,0,0,0,0,NalP,NONE,Q8GKS5,Involved in subtilase activity,NONE,NONE,,,,"
"
1j2z_v,4,2.952,0.7381,0.674047,1,0,3,0,0,0,Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase,NONE,O25927,Involved in acyltransferase activity,NONE,NONE,,,,"
"
1u2r_v,5,3.681,0.7362,2.54721,3,1,0,1,0,0,Elongation factor 2,NONE,P32324,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
1g67_v,4,2.944,0.7361,0.721085,2,1,1,0,0,0,Thiamine-phosphate pyrophosphorylase,NONE,P39594,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1xxs_v,4,2.944,0.7359,0.307754,3,0,0,0,1,0,Phospholipase A2 homolog 2,NONE,Q9I834,Involved in phospholipase A2 activity,NONE,NONE,,,,"
"
1lbs_v,4,2.943,0.7358,0.238492,3,1,0,0,0,0,Lipase B,NONE,P41365,Involved in triacylglycerol lipase activity,NONE,NONE,,,,"
"
1s39_v,4,2.942,0.7356,0.779881,1,1,2,0,0,0,Queuine tRNA-ribosyltransferase,NONE,P28720,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
1qu4_v,5,3.678,0.7355,2.41121,2,2,0,0,1,0,Ornithine decarboxylase,NONE,P07805,Amino acid transport and metabolism,NONE,NONE,,,,"
"
2toh_v,3,2.206,0.7355,-0.416245,1,0,2,0,0,0,Tyrosine 3-monooxygenase,NONE,P04177,Plays an important role in the physiology of adrenergic neurons.,NONE,NONE,,,,"
"
1afs_v,4,2.939,0.7348,0.100637,3,1,0,0,0,0,3-alpha-hydroxysteroid dehydrogenase,NONE,P23457,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1ekk_v,4,2.938,0.7346,0.526124,3,0,1,0,0,0,Hydroxyethylthiazole kinase,NONE,P39593,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1a8j_v,4,2.937,0.7341,0.853654,1,2,0,1,0,0,Ig lambda chain V-II region MGC,NONE,P01709,"V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).",NONE,NONE,,,,"
"
1p4t_v,3,2.202,0.7339,-1.52404,3,0,0,0,0,0,Surface protein A,NONE,Q9RP17,Involved in porin activity,NONE,NONE,,,,"
"
1fm6_v,4,2.935,0.7338,0.451119,3,1,0,0,0,0,Peroxisome proliferator-activated receptor gamma,TRANSCRIPTION,PPARG_HUMAN,"Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the pero","Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension.;Defects in PPARG may be associated with susceptibility to obesity [MIM:601665].;Defects in PPARG may be associated with colon cancer.;Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.;Variation in PPARG is associated with carotid intimal medial thickness 1 (CIMT1) [MIM:609338]. CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors.",Asthma;Cerebrovascular ischemia;Conjunctivitis;Inflammation;Multiple sclerosis;Fibrosis;Unidentified indication;Psoriasis;Heart arrhythmia;Rheumatoid arthritis;Atherosclerosis;Corneal disease;Cardiovascular disease;Ulcerative colitis;Alzheimers disease;Infertility;Syndrome X;Lipid metabolism disorder;Non-insulin dependent diabetes;Metabolic disorder;Diabetic complication;Hyperlipidemia;Lacrimal gland disease;Myocardial infarction;Obesity;Coronary artery disease;Insulin dependent diabetes;Vascular disease;Cancer;Cognitive disorder;Hypertension;Diabetes mellitus;Osteoporosis;Dermatological disease,,,,"
"
1t6c_v,4,2.933,0.7332,0.721619,2,2,0,0,0,0,Exopolyphosphatase,NONE,O67040,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1ek8_v,4,2.932,0.7331,-0.183979,4,0,0,0,0,0,Ribosome recycling factor,NONE,P0A808,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
2h8h_v,4,2.93,0.7326,0.591823,3,1,0,0,0,0,Proto-oncogene tyrosine-protein kinase Src,TRANSFERASE,SRC_HUMAN,NONE,NONE,Hypercalcemia;Cancer;Osteoporosis;Cerebrovascular ischemia;Bone metastases;Metastasis;Solid tumor,,,,"
"
1dgp_v,4,2.93,0.7325,0.294215,3,0,1,0,0,0,Aristolochene synthase,NONE,Q03471,Involved in magnesium ion binding,NONE,NONE,,,,"
"
1xan_v,4,2.928,0.732,0.554032,2,1,1,0,0,0,"Glutathione reductase, mitochondrial",NONE,P00390,RNA processing and modification,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1jxn_v,4,2.928,0.7319,0.825528,1,2,1,0,0,0,Anti-H(O) lectin 1,NONE,P22972,Involved in sugar binding,NONE,NONE,,,,"
"
1fw9_v,4,2.921,0.7303,0.213694,1,1,1,0,1,0,Chorismate--pyruvate lyase,NONE,P26602,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1e48_v,4,2.921,0.7302,0.285034,0,3,1,0,0,0,L-fuculose phosphate aldolase,NONE,P0AB87,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1rl4_v,4,2.917,0.7294,0.452722,2,1,1,0,0,0,"Formylmethionine deformylase, putative",NONE,Q8I372,Involved in iron ion binding,NONE,NONE,,,,"
"
1le6_v,4,2.915,0.7288,0.611112,2,1,1,0,0,0,Group 10 secretory phospholipase A2,NONE,O15496,Involved in phospholipase A2 activity,NONE,NONE,,,,"
"
1in4_v,3,2.185,0.7284,-0.720401,1,1,1,0,0,0,Holliday junction ATP-dependent DNA helicase ruvB,NONE,Q56313,Involved in nucleotide binding,NONE,NONE,,,,"
"
1doc_v,4,2.913,0.7281,0.168762,1,1,1,0,1,0,P-hydroxybenzoate hydroxylase,NONE,P20586,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1h3f_v,4,2.911,0.7277,0.683772,1,1,2,0,0,0,Tyrosyl-tRNA synthetase,NONE,P83453,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
1pkk_v,4,2.91,0.7276,0.73356,1,1,2,0,0,0,"dCTP deaminase, dUMP-forming",NONE,Q57872,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1gpj_v,4,2.91,0.7275,0.794593,0,2,1,1,0,0,Glutamyl-tRNA reductase,NONE,Q9UXR8,Involved in glutamyl-tRNA reductase activity,NONE,NONE,,,,"
"
1csb_v,4,2.91,0.7275,0.66474,1,3,0,0,0,0,Cathepsin B,HYDROLASE (THIOL PROTEASE),CATB_HUMAN,Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.,NONE,Myocardial infarction;Arthritis;Inflammation;Cancer,,,,"
"
1ra0_v,4,2.907,0.7266,0.692016,1,0,3,0,0,0,Cytosine deaminase,NONE,P25524,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1q9i_v,4,2.906,0.7265,0.450431,0,2,1,0,1,0,Fumarate reductase flavoprotein subunit,NONE,P0C278,Energy production and conversion,NONE,NONE,,,,"
"
2g5o_v,4,2.905,0.7263,0.752462,2,1,1,0,0,0,Estrogen receptor,HORMONE/GROWTH FACTOR RECEPTOR,ESR1_HUMAN,Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.,NONE,Melanoma;Brain tumor;Inflammation;Myocardial infarction;Fibrosis;Brain ischemia;Psoriasis;Rheumatoid arthritis;Retinitis pigmentosa;Atherosclerosis;Genitourinary disease;Breast disease;Atrophy;Crohns disease;Testosterone deficiency;Uterine fibroids;Fibrocystic breast disease;Arthralgia;Prostatitis;Prostate hyperplasia;Inflammatory bowel disease;Solid tumor;Gynecological disorder;Vascular disease;Contraception;Cancer;Sepsis;Hypercholesterolemia;Neurological disease;Ataxia;Cognitive disorder;Osteoporosis;Gynecomastia;Major depressive disorder;Acne;Female contraception;Dysmenorrhea;Neoplasm;Central nervous system disease;Multiple sclerosis;Alcoholism;Lacrimal gland disease;Carcinoma;Cardiovascular disease;Menopause;Unidentified indication;Alzheimers disease;Breast tumor;Scar tissue;Hyperlipidemia;Postmenopausal osteoporosis;Papillomavirus infection;Ovary tumor;Prostate tumor;Adrenal disease;Urinary dysfunction;Estrogen deficiency;Endometriosis;Hormone deficiency;Musculoskeletal disease;Glioma;Vagina disease;Non-small-cell lung cancer;Parkinsons disease;Uterus tumor;Psychiatric disorder,,,,"
"
1vh8_v,4,2.905,0.7262,0.00850597,0,3,0,0,1,0,"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase",NONE,P44815,"Involved in 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity",NONE,NONE,,,,"
"
1qfl_v,4,2.904,0.7259,0.77189,1,2,1,0,0,0,Acetyl-CoA acetyltransferase,NONE,P07097,Lipid transport and metabolism,NONE,NONE,,,,"
"
1g74_v,5,3.626,0.7251,1.36351,5,0,0,0,0,0,"Fatty acid-binding protein, adipocyte",NONE,P04117,Involved in fatty acid binding,NONE,NONE,,,,"
"
1gxz_v,4,2.898,0.7244,0.584782,1,2,1,0,0,0,T-cell ecto-ADP-ribosyltransferase 2,NONE,P20974,Involved in NAD(P)+-protein-arginine ADP-ribosyltransferase activity,NONE,NONE,,,,"
"
1q2b_v,4,2.897,0.7243,0.607124,0,4,0,0,0,0,Exoglucanase 1,NONE,P62694,"Involved in hydrolase activity, hydrolyzing O-glycosyl compounds",NONE,NONE,,,,"
"
1r15_v,5,3.62,0.7241,2.29597,0,2,2,0,1,0,ADP-ribosyl cyclase,NONE,P29241,Involved in NAD+ nucleosidase activity,NONE,NONE,,,,"
"
7prn_v,4,2.896,0.7241,0.628377,2,2,0,0,0,0,Porin,NONE,P39767,Forms channels that allow the passive diffusion of small hydrophilic solutes up to an exclusion limit of about 0.6 kDa,NONE,NONE,,,,"
"
1vbw_v,4,2.894,0.7235,0.263148,0,2,1,0,1,0,Trypsin inhibitor BGIT,NONE,Q7M1Q1,Involved in serine-type endopeptidase inhibitor activity,NONE,NONE,,,,"
"
1smj_v,5,3.617,0.7234,1.46352,5,0,0,0,0,0,Bifunctional P-450/NADPH-P450 reductase,NONE,P14779,Inorganic ion transport and metabolism,NONE,NONE,,,,"
"
1ref_v,4,2.891,0.7228,0.693388,1,1,2,0,0,0,"Endo-1,4-beta-xylanase 2",NONE,P36217,"Involved in hydrolase activity, hydrolyzing O-glycosyl compounds",NONE,NONE,,,,"
"
1ptr_v,5,3.613,0.7226,2.39641,2,1,2,0,0,0,Protein kinase C delta type,NONE,P28867,"Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion. Phosphorylates ELAVL1 in response to angiotensin-2 treatment (By similarity).",NONE,NONE,,,,"
"
1qbo_v,5,3.611,0.7222,2.47603,3,0,1,1,0,0,Cationic trypsin,NONE,P00760,Involved in protease activity,NONE,For the symptomatic relief of patients with interstitial cystitis.,,,,"
"
1uy9_v,4,2.886,0.7216,0.695957,1,1,1,0,0,1,Heat shock protein HSP 90-alpha,CHAPERONE,HS90A_HUMAN,Molecular chaperone. Has ATPase activity (By similarity).,NONE,NONE,,,,"
"
1po8_v,4,2.886,0.7214,0.120273,2,2,0,0,0,0,Phospholipase A2 KPA2,NONE,Q9DF52,Involved in phospholipase A2 activity,NONE,NONE,,,,"
"
1ldo_v,3,2.163,0.7209,-1.11589,0,2,1,0,0,0,Avidin,NONE,P02701,The biological function of avidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of avidin),NONE,NONE,,,,"
"
1g0i_v,4,2.88,0.7201,0.62558,0,2,2,0,0,0,Inositol-1-monophosphatase,NONE,Q57573,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1aql_v,4,2.878,0.7196,0.437916,2,1,1,0,0,0,Bile salt-activated lipase,NONE,P30122,Lipid transport and metabolism,NONE,NONE,,,,"
"
1l9w_v,4,2.878,0.7196,0.323707,1,1,1,0,1,0,3-dehydroquinate dehydratase,NONE,P24670,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1rtk_v,4,2.878,0.7195,0.543247,1,1,2,0,0,0,Complement factor B,HORMONE/GROWTH FACTOR,CFAB_HUMAN,"Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in",NONE,NONE,,,,"
"
1r6l_v,3,2.158,0.7195,-1.3637,1,2,0,0,0,0,Ribonuclease PH,NONE,P50597,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
1mfu_v,4,2.878,0.7194,0.546954,0,2,2,0,0,0,Alpha-amylase 1,NONE,P04745,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1r13_v,4,2.87,0.7176,0.505863,0,3,0,1,0,0,Pulmonary surfactant-associated protein A,NONE,P08427,Involved in binding,NONE,NONE,,,,"
"
1zyj_v,4,2.869,0.7171,0.113823,3,1,0,0,0,0,Mitogen-activated protein kinase 14,NONE,Q16539,Involved in MAP kinase activity,NONE,NONE,,,,"
"
5gal_v,4,2.868,0.7169,0.604568,0,4,0,0,0,0,Galectin-7,LECTIN,LEG7_HUMAN,Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.,NONE,NONE,,,,"
"
1gpz_v,4,2.867,0.7167,0.746979,1,1,2,0,0,0,Complement C1r subcomponent,NONE,P00736,"C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system",NONE,For treatment of metastatic colorectal cancer.,,,,"
"
1hcx_v,3,2.148,0.716,-1.49956,3,0,0,0,0,0,Autolysin,NONE,P06653,Involved in N-acetylmuramoyl-L-alanine amidase activity,NONE,NONE,,,,"
"
1k1e_v,4,2.863,0.7156,0.357992,1,3,0,0,0,0,3-deoxy-D-manno-octulosonate 8-phosphate phosphatase,NONE,P45314,Involved in catalytic activity,NONE,NONE,,,,"
"
1gcz_v,4,2.86,0.7151,0.540917,2,2,0,0,0,0,Macrophage migration inhibitory factor,IMMUNE SYSTEM,MIF_HUMAN,The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase.,"Genetic variations in MIF are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement.",Insulin dependent diabetes;Glomerulonephritis;Cancer;Rheumatoid arthritis;Sepsis;Autoimmune disease;Atherosclerosis;Infection;Inflammation;Myocardial infarction;Immune disorder,,,,"
"
1icn_v,5,3.572,0.7143,1.46129,5,0,0,0,0,0,"Fatty acid-binding protein, intestinal",NONE,P02693,Involved in transporter activity,NONE,NONE,,,,"
"
3fzk_v,4,2.857,0.7143,0.58615,2,2,0,0,0,0,Heat shock cognate 71 kDa protein,NONE,P11142,"Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24318877, PubMed:27474739, PubMed:24121476, PubMed:26865365). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462).",NONE,NONE,,,,"
"
1n1m_v,4,2.856,0.714,0.457271,2,1,0,1,0,0,Dipeptidyl peptidase 4,HYDROLASE,DPP4_HUMAN,Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Plays a role in T-cell activation.,NONE,Rheumatoid arthritis;Diabetes mellitus;Non-insulin dependent diabetes;Autoimmune disease;Immune disorder,,,,"
"
1rsi_v,4,2.855,0.7137,0.217213,2,1,1,0,0,0,Dihydroneopterin aldolase,NONE,P56740,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1k7s_v,4,2.854,0.7135,0.318559,2,2,0,0,0,0,Iron(3+)-hydroxamate-binding protein fhuD,NONE,P07822,Inorganic ion transport and metabolism,NONE,NONE,,,,"
"
1m5w_v,4,2.852,0.7131,0.251684,0,3,0,0,1,0,Pyridoxine 5-phosphate synthase,NONE,P0A794,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1tbb_v,4,2.852,0.713,0.511603,2,1,1,0,0,0,"cAMP-specific 3,5-cyclic phosphodiesterase 4D",HYDROLASE,PDE4D_HUMAN,Regulates the levels of cAMP in the cell.,"Genetic variations in PDE4D might be associated with susceptibility to stroke type 1 (STRK1) [MIM:606799]. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. PubMed:17006457 states that association with stroke has to be considered with caution.",NONE,,,,"
"
1xzl_v,4,2.844,0.7109,0.0408364,3,1,0,0,0,0,Cutinase 1,NONE,P00590,Involved in hydrolase activity,NONE,NONE,,,,"
"
1pq9_v,3,2.132,0.7106,-1.20833,1,2,0,0,0,0,Oxysterols receptor LXR-beta,TRANSCRIPTION REGULATION,NR1H2_HUMAN,Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5-AGGTCA-3 and 4-nt spacing (DR-4).,NONE,Lipid metabolism disorder;Atherosclerosis,,,,"
"
1hak_v,4,2.842,0.7105,-0.171873,3,1,0,0,0,0,Annexin A5,CALCIUM/PHOSPHOLIPID-BINDING,ANXA5_HUMAN,"This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.",NONE,NONE,,,,"
"
1phw_v,4,2.84,0.7101,-0.0229441,0,3,0,0,1,0,2-dehydro-3-deoxyphosphooctonate aldolase,NONE,P0A715,Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.,NONE,NONE,,,,"
"
1nwe_v,5,3.54,0.708,1.8593,2,2,0,0,1,0,Tyrosine-protein phosphatase non-receptor type 1,HYDROLASE,PTN1_HUMAN,May play an important role in CKII- and p60c-src-induced signal transduction cascades (By similarity).,NONE,NONE,,,,"
"
1bem_v,4,2.832,0.708,0.130435,1,3,0,0,0,0,"Cytochrome c peroxidase, mitochondrial",NONE,P00431,Inorganic ion transport and metabolism,NONE,NONE,,,,"
"
1ji4_v,4,2.826,0.7065,0.0353004,3,1,0,0,0,0,DNA protection during starvation protein,NONE,P43313,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
2gz8_v,4,2.825,0.7062,0.429874,3,1,0,0,0,0,Replicase polyprotein 1a,NONE,P0C6U8,"The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.",NONE,NONE,,,,"
"
2bq6_v,4,2.822,0.7055,0.513296,2,1,0,1,0,0,Coagulation factor X,HYDROLASE,FA10_HUMAN,"Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.",NONE,Thromboembolism,,,,"
"
1dic_v,4,2.821,0.7053,0.389177,2,2,0,0,0,0,Complement factor D,SERINE PROTEASE,CFAD_HUMAN,"Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.",Defects in CFD are the cause of complement factor D deficiency [MIM:134350]. This deficiency predisposes to invasive meningococcal disease.,Autoimmune disease;Reperfusion injury;Age related macular degeneration,,,,"
"
2izk_v,4,2.819,0.7047,0.510352,0,2,2,0,0,0,Streptavidin,NONE,P22629,The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin),NONE,NONE,,,,"
"
1lhw_v,4,2.819,0.7047,0.227173,2,2,0,0,0,0,Sex hormone-binding globulin,TRANSPORT PROTEIN,SHBG_HUMAN,"Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic cl",NONE,NONE,,,,"
"
1jyx_v,5,3.523,0.7045,2.39229,1,1,3,0,0,0,Beta-galactosidase,NONE,P00722,Carbohydrate transport and metabolism,NONE,For the symptomatic relief of patients with interstitial cystitis.,,,,"
"
1ojj_v,4,2.816,0.704,0.560125,0,2,2,0,0,0,Endoglucanase 1,NONE,P56680,"Involved in hydrolase activity, hydrolyzing O-glycosyl compounds",NONE,NONE,,,,"
"
1vhm_v,4,2.815,0.7038,0.425413,0,3,0,1,0,0,UPF0067 protein yebR,NONE,P76270,Signal transduction mechanisms,NONE,NONE,,,,"
"
1nl1_v,4,2.814,0.7034,0.40781,0,2,2,0,0,0,Prothrombin,NONE,P00735,Involved in protease and blood clotting activity,NONE,NONE,,,,"
"
1bav_v,4,2.812,0.7031,0.05586,2,1,0,0,1,0,Carboxypeptidase A1,NONE,P00730,"Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.",NONE,NONE,,,,"
"
1ju2_v,4,2.812,0.703,0.471899,0,2,2,0,0,0,(R)-mandelonitrile lyase 1,NONE,P52706,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1f4n_v,4,2.811,0.7029,0.451992,2,1,1,0,0,0,Regulatory protein rop,NONE,P03051,"Regulates plasmid DNA replication by modulating the initiation of transcription of the primer RNA precursor. Processing of the precursor of the primer, RNAII, is inhibited by hydrogen bonding of RNAII to its complementary sequence in RNAI. ROP increases the affinity of RNAI for RNAII and thus decreases the rate of replication initiation events",NONE,NONE,,,,"
"
1xsk_v,4,2.808,0.702,0.541276,1,1,2,0,0,0,Putative family 31 glucosidase yicI,NONE,P31434,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1uzr_v,4,2.806,0.7014,-0.112272,0,3,0,0,1,0,Ribonucleoside-diphosphate reductase subunit beta,NONE,Q9CBQ2,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
2of4_v,4,2.798,0.6996,0.461012,2,1,0,1,0,0,Proto-oncogene tyrosine-protein kinase LCK,TRANSFERASE,LCK_HUMAN,Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key,A chromosomal aberration involving LCK is found in leukemias. Translocation t(1;7)(p34;q34) with TCRB.,Psoriasis;Cancer;Rheumatoid arthritis;Cardiac failure;Atherosclerosis;Delayed hypersensitivity;Transplant rejection;Inflammation;Multiple sclerosis;Autoimmune disease,,,,"
"
1d7x_v,4,2.792,0.6981,0.519986,1,1,2,0,0,0,Stromelysin-1,HYDROLASE,MMP3_HUMAN,"Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.",NONE,NONE,,,,"
"
1lam_v,4,2.786,0.6966,0.287929,2,2,0,0,0,0,Cytosol aminopeptidase,NONE,P00727,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1td7_v,4,2.78,0.695,-0.0161764,3,0,1,0,0,0,Phospholipase A2 isoform 3,HYDROLASE,PA23_NAJSG,PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.,NONE,NONE,,,,"
"
1c4o_v,4,2.77,0.6925,-0.285988,3,0,1,0,0,0,UvrABC system protein B,NONE,Q56243,"Replication, recombination and repair",NONE,NONE,,,,"
"
2uxi_v,4,2.768,0.6919,0.463013,1,2,1,0,0,0,HTH-type transcriptional regulator ttgR,NONE,Q9AIU0,Represses expression from the ttgABC operon promoter and its own expression. Binds to a promoter region between the divergently transcribed ttgR and ttgABC genes/operons; in the presence of chloramphenicol or tetracycline this binding no longer occurs and ttgR and ttgABC are derepressed. This suggests that TtgR binds these antibiotics.,NONE,NONE,,,,"
"
2qwj_v,4,2.767,0.6917,0.270923,0,3,1,0,0,0,Neuraminidase,NONE,P03472,"Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication",NONE,NONE,,,,"
"
1aha_v,4,2.766,0.6915,0.144441,0,2,2,0,0,0,Ribosome-inactivating protein momordin I,NONE,P16094,Involved in rRNA N-glycosylase activity,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1rs6_v,4,2.764,0.6909,0.397709,0,1,3,0,0,0,"Nitric oxide synthase, brain",NONE,P29476,"Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.",NONE,NONE,,,,"
"
1il9_v,4,2.763,0.6906,0.311849,1,2,1,0,0,0,Ricin,NONE,P02879,Involved in rRNA N-glycosylase activity,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1mx1_v,4,2.761,0.6902,0.0523923,3,1,0,0,0,0,Liver carboxylesterase 1,HYDROLASE,EST1_HUMAN,"Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl CoA ester.",NONE,Arteriosclerosis;Cerebrovascular disease;Cancer;Melanoma;Multiple myeloma;Hypercholesterolemia;Atherosclerosis;Breast tumor;Hyperlipidemia;Solid tumor;Cardiovascular disease;Prostate tumor;Alzheimers disease;Dementia;Osteoporosis,,,,"
"
1agw_v,4,2.76,0.69,0.198547,2,1,1,0,0,0,Basic fibroblast growth factor receptor 1,PROTEIN KINASE,FGFR1_HUMAN,Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF).,"Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly.;Defects in FGFR1 are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadism is a condition characterized by abnormally decreased gonadal function, with retardation of growth and sexual development. Hypogonadotropic hypogonadism is due to inadequate secretion of gonadotropins. It results from failure to release sufficient gonadotropin-releasing hormone.;Defects in FGFR1 are the cause of Kallmann syndrome type 2 (KAL2) [MIM:147950]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. In some cases, midline cranial anomalies (cleft lip/palate and imperfect fusion) are present and anosmia may be absent or inconspicuous.;Defects in FGFR1 are the cause of osteoglophonic dysplasia (OGD) [MIM:166250]; also known as osteoglophonic dwarfism. OGD is characterized by craniosynostosis, prominent supraorbital ridge, and depressed nasal bridge, as well as by rhizomelic dwarfism and nonossifying bone lesions. Inheritance is autosomal dominant.;Defects in FGFR1 are the cause of non-syndromic trigonocephaly [MIM:190440]; also known as metopic craniosynostosis. The term trigonocephaly describes the typical keel-shaped deformation of the forehead resulting from premature fusion of the frontal suture. Trigonocephaly may occur also as a part of a syndrome.;A chromosomal aberration involving FGFR1 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with ZMYM2. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow.;A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1OP. Insertion ins(12;8)(p11;p11p22) with FGFR1OP2. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP2-FGFR1, FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.;A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with CEP110. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.",NONE,,,,"
"
1rzu_v,4,2.76,0.6899,0.277029,0,1,2,0,1,0,Glycogen synthase 1,NONE,P0A3F3,Involved in starch synthase activity,NONE,NONE,,,,"
"
1ih0_v,4,2.758,0.6894,0.148032,3,0,1,0,0,0,"Troponin C, slow skeletal and cardiac muscles",NONE,P63316,Involved in calcium ion binding,NONE,For short term treatment of acutely decompensated severe chronic heart failure (CHF). Also being investigated for use/treatment in heart disease.,,,,"
"
1b4w_v,4,2.755,0.6888,-0.209102,3,1,0,0,0,0,"Phospholipase A2, basic",NONE,P04417,Involved in phospholipase A2 activity,NONE,NONE,,,,"
"
1i78_v,4,2.754,0.6885,-0.183945,3,1,0,0,0,0,Protease 7,NONE,P09169,Involved in endopeptidase activity,NONE,NONE,,,,"
"
1zxc_v,4,2.754,0.6884,-0.0739421,3,1,0,0,0,0,ADAM 17,HYDROLASE,ADA17_HUMAN,"Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth",NONE,Psoriasis;Inflammation;Rheumatoid arthritis;Cardiac failure;Multiple sclerosis;Metastasis;Immune disorder,,,,"
"
1k0u_v,4,2.753,0.6883,0.18671,0,1,2,0,1,0,Adenosylhomocysteinase,NONE,P10760,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1oge_v,4,2.753,0.6883,0.106972,0,3,1,0,0,0,D-ribose pyranase,NONE,P36946,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
830c_v,4,2.753,0.6881,-0.0889496,3,1,0,0,0,0,Collagenase 3,MATRIX METALLOPROTEASE,MMP13_HUMAN,Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.,Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia type 2 (SEMD2) [MIM:602111]; also known as spondyloepimetaphyseal dysplasia type Missouri. SEMDs are a heterogeneous group of skeletal disorders characterized by defective growth and modeling of the spine and long bones. The SEMDs are distinguished from the spondylometaphyseal dysplasias and the spondyloepiphyseal dysplasias by the combined involvement of the epiphyses and metaphyses. The 3 disorders have malformations of the vertebrae in common.,NONE,,,,"
"
1ndf_v,4,2.753,0.6881,0.493278,0,2,1,1,0,0,Carnitine O-acetyltransferase,NONE,P47934,Involved in acyltransferase activity,NONE,NONE,,,,"
"
1t6z_v,4,2.752,0.688,0.159451,2,1,1,0,0,0,Riboflavin kinase/FMN adenylyltransferase,NONE,Q9WZW1,Involved in FMN adenylyltransferase activity,NONE,For the treatment of ariboflavinosis (vitamin B2 deficiency).,,,,"
"
1hzp_v,5,3.437,0.6875,1.11517,4,1,0,0,0,0,3-oxoacyl-[acyl-carrier-protein] synthase 3,NONE,P0A574,Lipid transport and metabolism,NONE,NONE,,,,"
"
1qoz_v,4,2.747,0.6867,0.0311297,0,2,2,0,0,0,Acetylxylan esterase,NONE,Q99034,"Involved in hydrolase activity, hydrolyzing O-glycosyl compounds",NONE,NONE,,,,"
"
1tuu_v,4,2.744,0.6859,0.27373,0,4,0,0,0,0,Acetate kinase,NONE,P38502,Involved in kinase activity,NONE,NONE,,,,"
"
1qwu_v,5,3.427,0.6855,1.37625,4,1,0,0,0,0,Alpha-mannosidase 2,NONE,Q24451,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1rzy_v,5,3.427,0.6854,2.42341,0,3,2,0,0,0,Histidine triad nucleotide-binding protein 1,NONE,P80912,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1s3y_v,4,2.74,0.685,0.0548705,2,0,2,0,0,0,Dihydrofolate reductase,NONE,P16184,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1e6w_v,4,2.732,0.6831,-0.299054,3,1,0,0,0,0,3-hydroxyacyl-CoA dehydrogenase type-2,NONE,O70351,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1gyy_v,4,2.731,0.6829,-0.154456,2,1,0,0,1,0,Probable tautomerase ydcE,NONE,P31992,Signal transduction mechanisms,NONE,NONE,,,,"
"
3cla_v,5,3.413,0.6826,2.04717,2,2,1,0,0,0,Chloramphenicol acetyltransferase 3,NONE,P00484,Involved in chloramphenicol O-acetyltransferase activity,NONE,"Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.",,,,"
"
2acl_v,4,2.73,0.6824,0.0992948,3,1,0,0,0,0,Retinoic acid receptor RXR-alpha,TRANSCRIPTION,RXRA_HUMAN,Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer (By similarity).,NONE,Acute promyelocytic leukemia,,,,"
"
2oax_v,4,2.729,0.6823,0.323523,2,2,0,0,0,0,Mineralocorticoid receptor,TRANSCRIPTION,MCR_HUMAN,Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water tr,"Defects in NR3C2 are a cause of autosomal dominant pseudohypoaldosteronism type I (PHA1) [MIM:177735]. PHA1 is characterized by urinary salt wasting, resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal dominant form that is mild, and the recessive form which is more severe and due to defects in any of the epithelial sodium channel subunits. In autosomal dominant PHA1 the target organ defect is confined to kidney. Clinical expression can vary from asymptomatic to moderate. It may be severe at birth, but symptoms remit with age. Familial and sporadic cases have been reported.;Defects in NR3C2 are a cause of early onset hypertension with severe exacerbation in pregnancy [MIM:605115]. Inheritance is autosomal dominant. The disease is characterized by the onset of severe hypertension before the age of 20, and by suppression of aldosterone secretion.",Metabolic disorder;Hypertension;Cardiovascular disease;Urinary tract disease,,,,"
"
2o8h_v,4,2.725,0.6811,0.425334,1,2,0,0,0,1,"cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A",NONE,Q9QYJ6,"Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.",NONE,NONE,,,,"
"
3f7z_v,5,3.404,0.6808,1.81062,3,2,0,0,0,0,Glycogen synthase kinase-3 beta,NONE,P49841,Involved in protein kinase activity,NONE,NONE,,,,"
"
1cs1_v,4,2.72,0.6799,-0.31039,0,4,0,0,0,0,Cystathionine gamma-synthase,NONE,P00935,Involved in pyridoxal phosphate binding,NONE,NONE,,,,"
"
4hmg_v,4,2.713,0.6782,0.101082,0,3,1,0,0,0,Hemagglutinin,NONE,P03437,Involved in host cell surface receptor binding,NONE,NONE,,,,"
"
1vjy_v,4,2.712,0.6781,-0.354456,3,1,0,0,0,0,TGF-beta receptor type-1,TRANSFERASE,TGFR1_HUMAN,"On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional","Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A) [MIM:609192]; also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS). LDS1 is an aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by arterial tortuosity and aneurysms, craniosynostosis, hypertelorism, and bifid uvula or cleft palate. Other findings include exotropy, micrognathia and retrognathia, structural brain abnormalities, intellectual deficit, congenital heart disease, translucent skin, joint hyperlaxity and aneurysm with dissection throughout the arterial tree.;Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 2A (LDS2A) [MIM:608967]. LDS2 is an aortic aneurysm syndrome with widespread systemic involvement. Physical findings include prominent joint laxity, easy bruising, wide and atrophic scars, velvety and translucent skin with easily visible veins, spontaneous rupture of the spleen or bowel, diffuse arterial aneurysms and dissections, and catastrophic complications of pregnancy, including rupture of the gravid uterus and the arteries, either during pregnancy or in the immediate postpartum period. LDS2 is characterized by the absence of craniofacial abnormalities with the exception of bifid uvula that can be present in some patients.;Defects in TGFBR1 are the cause of aortic aneurysm familial thoracic type 5 (AAT5) [MIM:608967]. Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as medial necrosis in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.",Skin burns;Glomerulonephritis;Wound healing;Renal disease;Scleroderma;Glaucoma;Diabetic complication;Scar tissue;Inflammation;Urinary tract disease;Pulmonary fibrosis;Diabetic nephropathy;Fibrosis;Solid tumor;Angiogenesis disorder;Glioma;Cancer;Atherosclerosis;Glomerular disease;Lung tumor;Nephritis;Immune disorder;Bone marrow transplantation,,,,"
"
1jup_v,5,3.39,0.6779,1.26365,5,0,0,0,0,0,HTH-type transcriptional regulator qacR,NONE,P0A0N4,"Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.",NONE,NONE,,,,"
"
1waw_v,4,2.704,0.6761,0.0151894,1,2,1,0,0,0,Chitotriosidase-1,NONE,Q13231,Involved in chitinase activity,NONE,NONE,,,,"
"
1u3v_v,4,2.703,0.6757,-0.0777151,2,0,1,1,0,0,Alcohol dehydrogenase 1B,OXIDOREDUCTASE,ADH1B_HUMAN,NONE,NONE,NONE,,,,"
"
1jgs_v,4,2.702,0.6755,-0.411938,1,2,0,0,1,0,Multiple antibiotic resistance protein marR,NONE,P27245,Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.,NONE,NONE,,,,"
"
1v0h_v,4,2.702,0.6754,0.17966,1,2,1,0,0,0,Ascorbate peroxidase,NONE,Q43758,Involved in peroxidase activity,NONE,"Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.",,,,"
"
1sm2_v,6,4.046,0.6744,2.93732,4,2,0,0,0,0,Tyrosine-protein kinase ITK/TSK,NONE,Q08881,Involved in protein kinase activity,NONE,NONE,,,,"
"
1fi1_v,4,2.693,0.6732,-0.27231,3,0,0,1,0,0,Ferrichrome-iron receptor,NONE,P06971,Inorganic ion transport and metabolism,NONE,NONE,,,,"
"
2bj7_v,4,2.692,0.673,0.30998,0,3,1,0,0,0,Putative nickel-responsive regulator,NONE,O58316,Involved in DNA binding,NONE,NONE,,,,"
"
1o3w_v,4,2.691,0.6728,0.306201,2,0,2,0,0,0,Phospholipase A2,NONE,P00593,Involved in phospholipase A2 activity,NONE,NONE,,,,"
"
1o8s_v,5,3.362,0.6725,1.66827,0,3,2,0,0,0,"Endo-1,4-beta-xylanase A",NONE,Q8GJ44,Endoxylanase that degrades arabinoxylan and glucuronoxylan to xylobiose and xylotriose (in vitro).,NONE,NONE,,,,"
"
2glm_v,4,2.688,0.672,0.409649,2,1,0,0,1,0,(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase,NONE,O25928,Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.,NONE,NONE,,,,"
"
1gpm_v,4,2.686,0.6714,-0.369222,0,3,1,0,0,0,GMP synthase [glutamine-hydrolyzing],NONE,P04079,Involved in catalytic activity,NONE,NONE,,,,"
"
1xmc_v,5,3.355,0.6711,1.60531,3,1,1,0,0,0,Peroxisomal carnitine O-octanoyltransferase,NONE,Q9DC50,Involved in acyltransferase activity,NONE,NONE,,,,"
"
1dgm_v,4,2.682,0.6706,-0.00845873,0,3,1,0,0,0,Adenosine kinase,NONE,Q9TVW2,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1nli_v,4,2.674,0.6685,0.0318847,0,2,2,0,0,0,Ribosome-inactivating protein alpha-trichosanthin,NONE,P09989,Involved in rRNA N-glycosylase activity,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1flz_v,4,2.67,0.6674,0.31919,0,2,2,0,0,0,Uracil-DNA glycosylase,NONE,P12295,Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.,NONE,NONE,,,,"
"
2fb8_v,4,2.669,0.6673,-0.218832,3,1,0,0,0,0,B-Raf proto-oncogene serine/threonine-protein kinase,TRANSFERASE,BRAF1_HUMAN,Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron.,"Defects in BRAF are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.;Defects in BRAF are involved in a wide range of cancers.;Defects in BRAF are involved in lung cancer [MIM:211980].;Defects in BRAF are involved in non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the bodys immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.;Defects in BRAF may be a cause of colorectal cancer (CRC) [MIM:114500].",Melanoma;Cancer,,,,"
"
1m7p_v,4,2.667,0.6668,-0.347395,0,3,0,0,1,0,Triosephosphate isomerase,NONE,Q07412,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1eqc_v,5,3.333,0.6667,1.67526,1,1,3,0,0,0,"Glucan 1,3-beta-glucosidase",NONE,P29717,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1n51_v,5,3.331,0.6663,1.59869,3,0,1,1,0,0,Xaa-Pro aminopeptidase,NONE,P15034,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1kwx_v,4,2.656,0.6639,-0.413564,0,3,1,0,0,0,Mannose-binding protein A,NONE,P19999,Involved in sugar binding,NONE,NONE,,,,"
"
1tal_v,4,2.656,0.6639,-0.166812,3,0,0,1,0,0,Alpha-lytic protease,NONE,P00778,Involved in serine-type peptidase activity,NONE,NONE,,,,"
"
1m4u_v,4,2.646,0.6615,-0.0075376,0,3,1,0,0,0,Bone morphogenetic protein 7,HORMONE/GROWTH FACTOR,BMP7_HUMAN,Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,NONE,Tooth disease;Brain injury;Motor neurone disease;Cerebrovascular ischemia;Bone disease;Parkinsons disease;Renal failure;Periodontal disease,,,,"
"
1f0n_v,4,2.642,0.6605,-0.308737,3,1,0,0,0,0,Antigen 85-B,NONE,P0C5B9,NONE,NONE,NONE,,,,"
"
1mkp_v,4,2.64,0.66,-0.154169,3,0,1,0,0,0,Dual specificity protein phosphatase 6,HYDROLASE,DUS6_HUMAN,Inactivates MAP kinases. Has a specificity for the ERK family.,NONE,NONE,,,,"
"
1umi_v,5,3.298,0.6596,1.74,0,3,2,0,0,0,F-box only protein 2,NONE,Q80UW2,"Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.",NONE,NONE,,,,"
"
1n2m_v,4,2.637,0.6592,-0.336092,3,0,1,0,0,0,Pyruvoyl-dependent arginine decarboxylase,NONE,Q57764,Involved in arginine decarboxylase activity,NONE,NONE,,,,"
"
1ddx_v,4,2.636,0.659,-0.457744,3,1,0,0,0,0,Prostaglandin G/H synthase 2,NONE,Q05769,Involved in peroxidase activity,NONE,NONE,,,,"
"
1sbr_v,5,3.291,0.6582,1.51769,2,2,1,0,0,0,Putative HMP/thiamine-binding protein ykoF,NONE,O34911,Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine. Could also transport other HMP-containing products. Binds thiamine via its HMP moiety.,NONE,NONE,,,,"
"
1xt4_v,4,2.632,0.658,0.123068,0,2,2,0,0,0,Uricase,NONE,Q00511,"Secondary metabolites biosynthesis, transport and catabolism",NONE,NONE,,,,"
"
1ttj_v,5,3.288,0.6575,1.22609,1,3,1,0,0,0,"Triosephosphate isomerase, glycosomal",NONE,P04789,Carbohydrate transport and metabolism,NONE,For the symptomatic relief of patients with interstitial cystitis.,,,,"
"
1i32_v,4,2.63,0.6575,0.0414379,1,1,2,0,0,0,"Glyceraldehyde-3-phosphate dehydrogenase, glycosomal",NONE,Q27890,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
2zas_v,4,2.629,0.6572,-0.355717,3,1,0,0,0,0,Estrogen-related receptor gamma,NONE,P62508,Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.,NONE,NONE,,,,"
"
1pl6_v,5,3.282,0.6564,0.979828,2,3,0,0,0,0,Sorbitol dehydrogenase,OXIDOREDUCTASE,DHSO_HUMAN,NONE,NONE,Diabetic complication,,,,"
"
1l1r_v,4,2.622,0.6554,-0.144288,1,2,1,0,0,0,Adenine phosphoribosyltransferase,NONE,Q967M2,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1n83_v,4,2.615,0.6538,-0.650014,4,0,0,0,0,0,Nuclear receptor ROR-alpha,LIPID BINDING PROTEIN,RORA_HUMAN,Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5-[AT][TA]A[AT][CGT]TAGGTCA-3.,NONE,NONE,,,,"
"
1mrq_v,5,3.268,0.6535,1.23427,4,1,0,0,0,0,Aldo-keto reductase family 1 member C1,NONE,Q04828,Involved in oxidoreductase activity,NONE,"Some evidence suggests that NADH might be useful in treating Parkinsons disease, chronic fatigue syndrome, Alzheimers disease and cardiovascular disease.",,,,"
"
1l5b_v,4,2.614,0.6534,-0.385385,1,1,1,0,1,0,Cyanovirin-N,NONE,P81180,Unknown,NONE,NONE,,,,"
"
1rxc_v,4,2.612,0.6529,0.145914,0,2,2,0,0,0,Uridine phosphorylase,NONE,P12758,Nucleotide transport and metabolism,NONE,"For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.",,,,"
"
1eb8_v,4,2.61,0.6525,-0.444521,3,1,0,0,0,0,Hydroxynitrilase,NONE,P52705,Involved in hydroxynitrilase activity,NONE,NONE,,,,"
"
1c1l_v,8,5.197,0.6497,1.33012,0,6,2,0,0,0,Congerin-1,NONE,P26788,Involved in sugar binding,NONE,NONE,,,,"
"
1w6j_v,5,3.24,0.6479,1.25021,2,2,1,0,0,0,Lanosterol synthase,ISOMERASE,ERG7_HUMAN,"Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.",NONE,Hyperlipidemia;Hypercholesterolemia;Atherosclerosis,,,,"
"
1q11_v,5,3.238,0.6476,1.4153,2,1,1,1,0,0,"Tyrosyl-tRNA synthetase, cytoplasmic",NONE,P54577,"Translation, ribosomal structure and biogenesis",NONE,"Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies.",,,,"
"
1b66_v,4,2.59,0.6474,-0.166198,1,1,2,0,0,0,6-pyruvoyl tetrahydrobiopterin synthase,NONE,P27213,Involved in 6-pyruvoyltetrahydropterin synthase activity,NONE,NONE,,,,"
"
2ddh_v,4,2.589,0.6474,-0.894226,3,0,0,0,1,0,Peroxisomal acyl-coenzyme A oxidase 1,NONE,P07872,Involved in acyl-CoA oxidase activity,NONE,NONE,,,,"
"
1hsr_v,4,2.589,0.6473,-0.428462,1,2,1,0,0,0,Peroxidase,NONE,P28313,Involved in peroxidase activity,NONE,NONE,,,,"
"
1g93_v,4,2.589,0.6473,-0.365373,0,2,2,0,0,0,"N-acetyllactosaminide alpha-1,3-galactosyltransferase",NONE,P14769,"Involved in transferase activity, transferring hexosyl groups",NONE,NONE,,,,"
"
1of7_v,5,3.236,0.6472,1.62452,2,1,2,0,0,0,"Aldehyde dehydrogenase, mitochondrial",OXIDOREDUCTASE,ALDH2_HUMAN,NONE,NONE,NONE,,,,"
"
1kmo_v,5,3.235,0.647,0.901723,4,0,0,1,0,0,Iron(III) dicitrate transport protein fecA,NONE,P13036,Inorganic ion transport and metabolism,NONE,NONE,,,,"
"
1thq_v,5,3.23,0.6461,0.978692,4,0,0,1,0,0,Protein crcA,NONE,P37001,Not known; overproduction leads to camphor resistance and chromosome condensation,NONE,NONE,,,,"
"
1e4o_v,5,3.227,0.6454,1.10984,2,2,0,0,1,0,Maltodextrin phosphorylase,NONE,P00490,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1p7c_v,5,3.227,0.6454,1.31977,0,4,1,0,0,0,Thymidine kinase,TRANSFERASE,KITH_HHV11,"In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).",NONE,Leukemia;Viral infection;Glioma;Cancer;Herpes simplex virus infection;Solid tumor;Varicella zoster virus infection;Liver tumor;HIV infection;Brain tumor;Graft versus host disease;Prostate tumor;Pancreas tumor;Melanoma;Cytomegalovirus infection;Ovary tumor,,,,"
"
1ndv_v,6,3.864,0.6441,2.4978,3,1,1,1,0,0,Adenosine deaminase,NONE,P56658,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1i4u_v,4,2.575,0.6437,-0.190288,2,1,1,0,0,0,Crustacyanin-C1 subunit,NONE,P80029,Involved in binding,NONE,NONE,,,,"
"
1duv_v,5,3.214,0.6429,1.03778,3,2,0,0,0,0,Ornithine carbamoyltransferase chain I,NONE,P04391,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1cw4_v,4,2.566,0.6415,-0.895085,0,3,0,0,1,0,Isocitrate dehydrogenase [NADP],NONE,P08200,Energy production and conversion,NONE,NONE,,,,"
"
1xdc_v,5,3.197,0.6395,1.24197,2,1,2,0,0,0,"Superoxide dismutase [Mn], mitochondrial",NONE,P04179,Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.,NONE,NONE,,,,"
"
1dam_v,6,3.835,0.6391,1.97337,3,1,2,0,0,0,Dethiobiotin synthetase,NONE,P13000,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
3mde_v,6,3.834,0.6391,0.303815,5,1,0,0,0,0,"Medium-chain specific acyl-CoA dehydrogenase, mitochondrial",NONE,P41367,Lipid transport and metabolism,NONE,NONE,,,,"
"
1lrh_v,4,2.554,0.6385,-0.131027,2,1,0,0,1,0,Auxin-binding protein 1,NONE,P13689,Involved in auxin hormone binding activity,NONE,NONE,,,,"
"
1exw_v,6,3.831,0.6384,2.14719,5,1,0,0,0,0,Palmitoyl-protein thioesterase 1,NONE,P45478,Involved in palmitoyl-(protein) hydrolase activity,NONE,NONE,,,,"
"
1lu0_v,4,2.549,0.6372,-0.342608,2,1,1,0,0,0,Trypsin inhibitor 1,NONE,P01074,Involved in serine-type endopeptidase inhibitor activity,NONE,NONE,,,,"
"
1tx2_v,4,2.541,0.6353,-0.28262,0,2,2,0,0,0,Dihydropteroate synthase,NONE,Q81VW8,Involved in dihydropteroate synthase activity,NONE,NONE,,,,"
"
1f07_v,4,2.541,0.6353,-0.0164073,2,1,1,0,0,0,"5,10-methylenetetrahydromethanopterin reductase",NONE,Q50744,Energy production and conversion,NONE,NONE,,,,"
"
1jc9_v,4,2.54,0.635,-0.124049,0,2,2,0,0,0,Techylectin-5A,NONE,Q9U8W8,"Lectin involved in innate immunity. Agglutinates all types of human erythrocytes, Gram-positive and Gram-negative bacteria. Has a stronger agglutinating activity towards Gram-negative bacteria than towards Gram-positive bacteria. Specifically recognizes acetyl group-containing substances on agglutinated cells. The hemagglutinating activity was inhibited by EDTA, acetyl group-containing mono- and disaccharides, N-acetyl derivatives of amino acids, other acetyl group-containing substances, propionamide and benzamide. Enhances the antimicrobial activity of big defensin against Gram-positive bacteria but not against Gram-negative bacteria.",NONE,NONE,,,,"
"
1ado_v,5,3.174,0.6348,-0.13376,0,4,0,0,1,0,Fructose-bisphosphate aldolase A,NONE,P00883,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1e70_v,5,3.163,0.6326,1.23636,1,2,2,0,0,0,Myrosinase MA1,NONE,P29736,"Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.",NONE,NONE,,,,"
"
1xpo_v,4,2.53,0.6326,-0.275758,1,2,1,0,0,0,Transcription termination factor rho,NONE,P0AG30,"Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template. RNA-dependent NTPase which utilizes all four ribonucleoside triphosphates as substrates.",NONE,NONE,,,,"
"
1t7v_v,4,2.53,0.6324,-0.047712,0,3,1,0,0,0,Zinc-alpha-2-glycoprotein,LIPID BINDING PROTEIN,ZA2G_HUMAN,Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.,NONE,NONE,,,,"
"
1t2b_v,4,2.527,0.6317,-1.20981,4,0,0,0,0,0,P450cin,NONE,Q8VQF6,Involved in monooxygenase activity,NONE,NONE,,,,"
"
1id8_v,4,2.524,0.6311,-1.22507,4,0,0,0,0,0,Methylaspartate mutase S chain,NONE,Q05488,Lipid transport and metabolism,NONE,NONE,,,,"
"
2g1y_v,4,2.524,0.631,-0.133851,2,1,1,0,0,0,Renin,HYDROLASE,RENI_HUMAN,"Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney","Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).",Glaucoma;Renal disease;Cardiac failure;Atherosclerosis;HIV infection;Hypertension;Cardiovascular disease;Ocular hypertension;Renal failure,,,,"
"
1tu5_v,4,2.516,0.6291,-0.233399,0,2,1,1,0,0,"Copper amine oxidase, liver isozyme",NONE,Q29437,"Secondary metabolites biosynthesis, transport and catabolism",NONE,NONE,,,,"
"
1kpl_v,5,3.14,0.6281,0.734898,5,0,0,0,0,0,H(+)/Cl(-) exchange transporter clcA,NONE,Q8ZRP8,Inorganic ion transport and metabolism,NONE,NONE,,,,"
"
2fus_v,4,2.51,0.6274,-0.609356,0,4,0,0,0,0,Fumarate hydratase class II,NONE,P05042,Energy production and conversion,NONE,NONE,,,,"
"
3f5p_v,4,2.509,0.6273,-0.473244,3,1,0,0,0,0,Insulin-like growth factor 1 receptor,NONE,P08069,Involved in transmembrane receptor protein tyrosine kinase activity,NONE,For treatment of diabetes (type I and II),,,,"
"
1fzv_v,5,3.134,0.6267,1.08097,3,0,2,0,0,0,Placenta growth factor,HORMONE/GROWTH FACTOR,PLGF_HUMAN,"Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. It binds to receptor VEGFR-1/FLT1. PLGF-2 binds neuropilin-1 and 2 in a heparin-dependent manner.",NONE,Retinopathy;Vascular disease;Diabetic macular edema;Inflammation;Cancer;Gastrointestinal disease;Age related macular degeneration,,,,"
"
1rdp_v,4,2.505,0.6263,-0.317523,0,2,2,0,0,0,Cholera enterotoxin subunit B,NONE,P01556,The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself,NONE,NONE,,,,"
"
1k6s_v,4,2.504,0.626,-0.114417,1,2,1,0,0,0,Beta-lactamase OXA-10,NONE,P14489,Defense mechanisms and antibiotic degradation,NONE,"For use as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms: complicated skin and skin structure infections due to Staphylococcus aureus (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (excluding vancomycin-resistant isolates), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis and Peptostreptococcus species; complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. Also for use in the treatment of bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (b-lactamase and non-b-lactamase-producing isolates), and Neisseria meningitidis.",,,,"
"
1k4w_v,6,3.754,0.6256,1.61318,5,1,0,0,0,0,Nuclear receptor ROR-beta,NONE,P45446,"Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity.",NONE,NONE,,,,"
"
1m6k_v,5,3.123,0.6247,1.02538,3,1,1,0,0,0,Beta-lactamase OXA-1,NONE,P13661,Defense mechanisms and antibiotic degradation,NONE,NONE,,,,"
"
1uwc_v,4,2.499,0.6246,-0.660233,1,2,1,0,0,0,Feruloyl esterase A,NONE,O42807,"Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Binds to cellulose.",NONE,NONE,,,,"
"
2ay9_v,6,3.747,0.6245,2.44286,2,2,0,0,1,1,Aromatic-amino-acid aminotransferase,NONE,P95468,Amino acid transport and metabolism,NONE,NONE,,,,"
"
2arc_v,4,2.498,0.6245,-0.449494,0,2,2,0,0,0,Arabinose operon regulatory protein,NONE,P0A9E0,This protein controls the expression of at least six genes that are involved in the transport and catabolism of L-arabinose. It regulates initiation of transcription of the araBAD operon and it also controls its own synthesis. The L-arabinose operon displays both positive and negative regulation through AraC.,NONE,NONE,,,,"
"
1woq_v,4,2.49,0.6225,-0.50862,0,2,2,0,0,0,Inorganic polyphosphate/ATP-glucomannokinase,NONE,Q7WT42,Transcription,NONE,NONE,,,,"
"
1fp1_v,5,3.11,0.622,0.94141,2,3,0,0,0,0,Isoliquiritigenin 2-O-methyltransferase,NONE,P93324,"Secondary metabolites biosynthesis, transport and catabolism",NONE,NONE,,,,"
"
1frz_v,4,2.487,0.6218,-0.598234,0,2,1,0,1,0,Glucosamine-6-phosphate deaminase,NONE,P0A759,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1pzn_v,4,2.486,0.6215,-1.41942,4,0,0,0,0,0,DNA repair and recombination protein radA,NONE,O74036,Involved in nucleotide binding,NONE,NONE,,,,"
"
3bbt_v,6,3.722,0.6204,2.29931,5,1,0,0,0,0,Receptor tyrosine-protein kinase erbB-4,TRANSFERASE,ERBB4_HUMAN,"Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin.",NONE,NONE,,,,"
"
1vr0_v,4,2.481,0.6203,-1.52726,0,3,0,0,1,0,Probable 2-phosphosulfolactate phosphatase,NONE,Q97E82,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1m2r_v,4,2.477,0.6193,-0.235856,2,1,1,0,0,0,Casein kinase II subunit alpha,NONE,P28523,Involved in protein kinase activity,NONE,NONE,,,,"
"
3std_v,5,3.093,0.6185,0.643661,4,1,0,0,0,0,Scytalone dehydratase,NONE,P56221,Involved in hydro-lyase activity,NONE,NONE,,,,"
"
1y2u_v,4,2.471,0.6176,-0.209201,0,2,2,0,0,0,Agaricus bisporus lectin,NONE,Q00022,"Lectin that recognizes O-linked galactose-beta-1,3-N-acetylgalactosamine, a disaccharide (Thomsen-Friedenreich antigen or T-disaccharide), present on cell surface glycoproteins. Can also bind galactose-beta-1,3-N-acetylglucosamine. Does not bind monosaccharides. Can be internalized by clathrin-coated vesicles after binding to surface glycoproteins. After internalization it inhibits nuclear import of nuclear localization signal dependent proteins. Inhibits proliferation of malignant cells without cytotoxicity for normal cells.",NONE,NONE,,,,"
"
1hxp_v,5,3.082,0.6165,0.890486,0,4,1,0,0,0,Galactose-1-phosphate uridylyltransferase,NONE,P09148,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1j1r_v,4,2.464,0.6159,-0.694719,0,2,2,0,0,0,Antiviral protein S,NONE,P23339,Involved in rRNA N-glycosylase activity,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1m6w_v,5,3.075,0.615,0.533464,3,0,1,0,1,0,Alcohol dehydrogenase class-3,OXIDOREDUCTASE,ADHX_HUMAN,"Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.",NONE,NONE,,,,"
"
1v0f_v,4,2.456,0.6141,-0.183543,0,4,0,0,0,0,Endo-N-acetylneuraminidase,NONE,Q04830,Involved in endo-alpha-sialidase activity,NONE,NONE,,,,"
"
1qfs_v,6,3.67,0.6116,2.46066,3,3,0,0,0,0,Prolyl endopeptidase,NONE,P23687,Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.,NONE,NONE,,,,"
"
2sn3_v,4,2.445,0.6113,-0.480124,2,2,0,0,0,0,Toxin CsEv3,NONE,P01494,Involved in sodium channel inhibitor activity,NONE,NONE,,,,"
"
1d3g_v,4,2.444,0.6109,-0.863488,3,0,1,0,0,0,"Dihydroorotate dehydrogenase, mitochondrial",OXIDOREDUCTASE,PYRD_HUMAN,NONE,NONE,NONE,,,,"
"
1u8x_v,5,3.053,0.6106,0.840546,0,2,2,0,1,0,Maltose-6-phosphate glucosidase,NONE,P54716,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1pzm_v,5,3.05,0.6099,0.316982,0,5,0,0,0,0,Hypoxanthine-guanine phosphoribosyltransferase,NONE,Q9NJI5,Involved in hypoxanthine phosphoribosyltransferase activity,NONE,NONE,,,,"
"
1wds_v,6,3.654,0.6089,2.26838,0,6,0,0,0,0,Beta-amylase,HYDROLASE,AMYB_SOYBN,NONE,NONE,NONE,,,,"
"
1w2g_v,5,3.042,0.6084,0.761156,1,2,2,0,0,0,Thymidylate kinase,NONE,O05891,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
2blb_v,4,2.43,0.6076,-0.254199,2,0,2,0,0,0,Bifunctional dihydrofolate reductase-thymidylate synthase,NONE,O02604,"Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.",NONE,NONE,,,,"
"
1dqp_v,4,2.422,0.6055,-0.271969,0,1,3,0,0,0,Guanine phosphoribosyltransferase,NONE,Q24973,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1kta_v,4,2.416,0.6039,-1.48226,1,2,0,0,1,0,"Branched-chain-amino-acid aminotransferase, mitochondrial",NONE,O15382,Amino acid transport and metabolism,NONE,For nutritional supplementation and for treating dietary shortage or imbalance.,,,,"
"
1bte_v,4,2.413,0.6033,-0.851719,0,2,2,0,0,0,Activin receptor type-2A,NONE,P27038,"On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555).",NONE,NONE,,,,"
"
2g8n_v,5,3.015,0.6029,0.683529,3,0,1,1,0,0,Phenylethanolamine N-methyltransferase,TRANSFERASE,PNMT_HUMAN,Converts noradrenaline to adrenaline.,NONE,NONE,,,,"
"
1ss4_v,4,2.41,0.6025,-0.488425,1,2,1,0,0,0,Glyoxalase family protein,NONE,Q81F54,Amino acid transport and metabolism,NONE,NONE,,,,"
"
4sli_v,5,3,0.6001,0.395907,1,2,1,0,1,0,Anhydrosialidase,NONE,Q27701,"Elimination of alpha-sialyl groups in N- acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N- acetylneuraminate",NONE,NONE,,,,"
"
1xie_v,5,3,0.6,0.355345,0,3,2,0,0,0,Xylose isomerase,NONE,P24300,Carbohydrate transport and metabolism,NONE,"Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.",,,,"
"
1oiz_v,5,2.999,0.5999,0.32201,4,1,0,0,0,0,Alpha-tocopherol transfer protein,NONE,P49638,Involved in vitamin E transporter activity,NONE,"Vitamin E, known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects. It may be of limited benefit in some with asthma and rheumatoid arthritis. It may be helpful in some neurological diseases including Alzheimers, some eye disorders including cataracts, and diabetes and premenstrual syndrome. It may also help protect skin from ultraviolet irradiation although claims that it reverses skin aging, enhances male fertility and exercise performance are poorly supported. It may help relieve some muscle cramps.",,,,"
"
1yys_v,5,2.996,0.5993,0.0991636,4,0,0,1,0,0,Trichodiene synthase,NONE,P13513,Involved in trichodiene synthase activity,NONE,NONE,,,,"
"
1ddv_v,5,2.99,0.598,0.890047,2,2,1,0,0,0,Homer protein homolog 1,NONE,Q9Z214,"Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 3 counteracts the effects by competing for binding sites. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, and isoform 2 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.",NONE,NONE,,,,"
"
1xnx_v,5,2.99,0.5979,-0.0886475,4,1,0,0,0,0,Orphan nuclear receptor NR1I3,NONE,O35627,Involved in transcription factor activity,NONE,NONE,,,,"
"
1lox_v,5,2.988,0.5976,0.0663866,4,0,0,0,1,0,Arachidonate 15-lipoxygenase,NONE,P12530,"Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.",NONE,NONE,,,,"
"
1tdj_v,4,2.39,0.5975,-1.47015,1,2,0,0,1,0,Threonine dehydratase biosynthetic,NONE,P04968,"Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.",NONE,NONE,,,,"
"
1r0p_v,6,3.583,0.5971,1.5382,4,2,0,0,0,0,Hepatocyte growth factor receptor,TRANSFERASE,MET_HUMAN,"Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.","Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.;Defects in MET may be associated with gastric cancer.;Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550].;Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance.;Genetic variations in MET may be associated with susceptibility to autism type 9 (AUTS9) [MIM:611015]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.","Alopecia, drug-induced;Mucositis;Cancer;Glioma;Metastasis;Renal cell carcinoma;Head and neck tumor;Brain tumor;Pancreas tumor;Solid tumor;Stomach tumor",,,,"
"
1bf6_v,5,2.985,0.597,0.56787,3,1,1,0,0,0,Phosphotriesterase homology protein,NONE,P45548,Involved in zinc ion binding,NONE,NONE,,,,"
"
1s1j_v,4,2.388,0.597,-0.995866,2,2,0,0,0,0,Cell division protein zipA,CELL CYCLE,ZIPA_ECOLI,"Interacts directly with the cell division protein ftsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.",NONE,Bacterial infection,,,,"
"
1s1p_v,5,2.985,0.5969,0.567637,3,2,0,0,0,0,Aldo-keto reductase family 1 member C3,OXIDOREDUCTASE,AK1C3_HUMAN,"Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-",NONE,NONE,,,,"
"
1h6g_v,5,2.984,0.5968,0.560764,3,2,0,0,0,0,Catenin alpha-1,CYTOSKELETON,CTNA1_HUMAN,"Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties",Abnormalities of alpha-catenin are involved in the process of cancer invasion and metastasis.,NONE,,,,"
"
1j17_v,5,2.982,0.5964,0.236273,4,1,0,0,0,0,Anionic trypsin-2,NONE,P00763,Involved in protease activity,NONE,NONE,,,,"
"
1qrd_v,5,2.979,0.5958,0.428256,4,0,0,0,0,1,NAD(P)H dehydrogenase [quinone] 1,NONE,P05982,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
3f0r_v,5,2.977,0.5954,0.359751,4,0,1,0,0,0,Histone deacetylase 8,NONE,Q9BY41,Chromatin structure and dynamics,NONE,"For the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies.",,,,"
"
1yw7_v,5,2.977,0.5953,0.389908,3,1,0,0,1,0,Methionine aminopeptidase 2,HYDROLASE,AMPM2_HUMAN,Removes the amino-terminal methionine from nascent proteins.,NONE,NONE,,,,"
"
1iud_v,6,3.571,0.5952,2.24673,0,4,2,0,0,0,Maltose-binding periplasmic protein,NONE,P0AEY0,Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).,NONE,NONE,,,,"
"
1dqy_v,5,2.974,0.5949,0.375067,3,1,1,0,0,0,Antigen 85-C,NONE,P0A4V4,"Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity",NONE,NONE,,,,"
"
2trx_v,5,2.973,0.5946,0.6363,3,1,1,0,0,0,Thioredoxin-1,NONE,P0AA25,"Posttranslational modification, protein turnover, chaperones",NONE,NONE,,,,"
"
1kjp_v,4,2.376,0.594,-0.851499,1,2,1,0,0,0,Thermolysin,NONE,P00800,Extracellular zinc metalloprotease.,NONE,NONE,,,,"
"
1o6q_v,6,3.559,0.5932,1.91595,5,0,0,1,0,0,Squalene--hopene cyclase,NONE,P33247,Lipid transport and metabolism,NONE,NONE,,,,"
"
1xbc_v,5,2.963,0.5926,0.433692,3,1,1,0,0,0,Tyrosine-protein kinase SYK,TRANSFERASE,KSYK_HUMAN,"Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through",NONE,Systemic lupus erythematosus;Asthma;Rheumatoid arthritis;Allergy;Allergic rhinitis;Inflammation;Thrombocytopenic purpura;Acute myelogenous leukemia;Lymphoma,,,,"
"
1i2k_v,5,2.962,0.5923,0.0155744,2,2,0,0,1,0,Aminodeoxychorismate lyase,NONE,P28305,Involved in catalytic activity,NONE,NONE,,,,"
"
1odu_v,5,2.961,0.5922,0.762701,1,1,3,0,0,0,"Alpha-L-fucosidase, putative",NONE,Q9WYE2,Involved in alpha-L-fucosidase activity,NONE,NONE,,,,"
"
1tpz_v,5,2.961,0.5922,0.671369,3,0,2,0,0,0,Interferon-inducible GTPase 1,NONE,Q9QZ85,May play a role in resistance to intracellular pathogens. Has low GTPase activity. Has higher affinity for GDP than for GTP,NONE,NONE,,,,"
"
1mdr_v,5,2.958,0.5916,0.281713,2,1,1,0,1,0,Mandelate racemase,NONE,P11444,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1u1j_v,5,2.957,0.5913,0.286564,2,1,0,1,1,0,5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase,NONE,O50008,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1d7o_v,6,3.547,0.5912,1.16485,5,0,1,0,0,0,"Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic",NONE,P80030,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1xry_v,4,2.361,0.5903,-0.517813,2,1,1,0,0,0,Bacterial leucyl aminopeptidase,NONE,Q01693,Involved in peptidase activity,NONE,NONE,,,,"
"
1m7w_v,5,2.951,0.5902,-0.116604,4,0,0,0,1,0,Hepatocyte nuclear factor 4-alpha,NONE,P22449,Involved in transcription factor activity,NONE,NONE,,,,"
"
1lri_v,8,4.716,0.5896,2.32701,7,0,1,0,0,0,Beta-elicitin cryptogein,NONE,P15570,Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families. Elicit leaf necrosis and cause the accumulation of pathogenesis-related proteins. Might interact with the lipidic molecules of the plasma membrane,NONE,NONE,,,,"
"
1h74_v,5,2.947,0.5894,0.100676,2,1,0,1,1,0,Homoserine kinase,NONE,Q58504,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1f1v_v,5,2.945,0.589,0.388406,1,2,1,0,1,0,"3,4-dihydroxyphenylacetate 2,3-dioxygenase",NONE,Q44048,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1c8u_v,6,3.533,0.5888,0.971889,4,0,1,1,0,0,Acyl-CoA thioesterase 2,NONE,P0AGG2,Lipid transport and metabolism,NONE,NONE,,,,"
"
1osh_v,5,2.944,0.5888,0.175069,5,0,0,0,0,0,Bile acid receptor,TRANSCRIPTION,NR1H4_HUMAN,"Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the tr",NONE,Liver fibrosis;Non-insulin dependent diabetes;Atherosclerosis;Hypertriglyceridemia;Hyperlipidemia;Liver disease;Primary biliary cirrhosis;Non-alcoholic steatohepatitis,,,,"
"
1fui_v,5,2.94,0.588,0.404431,1,2,2,0,0,0,L-fucose isomerase,NONE,P69923,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1e8z_v,5,2.937,0.5874,0.344171,3,1,0,1,0,0,"Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform",PHOSPHOINOSITIDE 3-KINASE GAMMA,PK3CG_HUMAN,"3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5- triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.",NONE,NONE,,,,"
"
1u88_v,5,2.937,0.5873,0.540902,2,1,0,1,1,0,Glutathione S-transferase class-mu 26 kDa isozyme,NONE,P08515,Involved in glutathione transferase activity,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1cg1_v,4,2.346,0.5864,-1.38704,0,1,2,0,1,0,Adenylosuccinate synthetase,NONE,P0A7D4,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1nkx_v,5,2.929,0.5858,0.786796,0,3,2,0,0,0,Lactotransferrin,NONE,P24627,Involved in ferric iron binding,NONE,NONE,,,,"
"
1utt_v,5,2.929,0.5857,0.346361,2,3,0,0,0,0,Macrophage metalloelastase,HYDROLASE,MMP12_HUMAN,"May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1 site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydr",NONE,Chronic obstructive pulmonary disease,,,,"
"
1dog_v,5,2.927,0.5854,0.445775,0,2,2,1,0,0,Glucoamylase I,NONE,P23176,NONE,NONE,NONE,,,,"
"
1sr9_v,5,2.926,0.5853,0.00255074,2,2,0,0,1,0,2-isopropylmalate synthase,NONE,P96420,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1waj_v,5,2.926,0.5852,0.438642,0,2,3,0,0,0,DNA polymerase,NONE,Q38087,"Replication, recombination and repair",NONE,NONE,,,,"
"
1k7t_v,5,2.925,0.585,0.509064,0,4,1,0,0,0,Agglutinin isolectin 3,NONE,P10969,Involved in chitin binding,NONE,NONE,,,,"
"
1kru_v,5,2.919,0.5838,0.585665,1,1,3,0,0,0,Galactoside O-acetyltransferase,NONE,P07464,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1fk1_v,6,3.5,0.5833,1.03133,4,2,0,0,0,0,Nonspecific lipid-transfer protein,NONE,P19656,Involved in lipid binding,NONE,NONE,,,,"
"
1m51_v,6,3.497,0.5828,0.606338,3,3,0,0,0,0,"Phosphoenolpyruvate carboxykinase, cytosolic [GTP]",NONE,P35558,Energy production and conversion,NONE,NONE,,,,"
"
1t84_v,5,2.913,0.5825,-0.217747,5,0,0,0,0,0,Wiskott-Aldrich syndrome protein,SIGNALING PROTEIN,WASP_HUMAN,"Effector protein for Rho-type GTPases, providing a link with the Arp2/3 complex that regulates the structure and dynamics of the actin cytoskeleton. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function.","Defects in WAS are the cause of Wiskott-Aldrich syndrome (WAS) [MIM:301000]; also known as eczema-thrombocytopenia- immunodeficiency syndrome. WAS is an X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, recurrent infections, and bloody diarrhea. Death usually occurs before age 10.;Defects in WAS are the cause of thrombocytopenia type 1 (THC1) [MIM:313900]. Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.;Defects in WAS are a cause of X-linked severe congenital neutropenia (XLN) [MIM:300299]. XLN is an X-linked immunodeficiency syndrome characterized by recurrent major bacterial infections, severe congenital neutropenia, and monocytopenia.",Wiskott-Aldrich syndrome,,,,"
"
1pdz_v,5,2.913,0.5825,-0.0900555,1,2,0,0,2,0,Enolase,NONE,P56252,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1cgz_v,5,2.912,0.5824,0.346108,2,1,2,0,0,0,Chalcone synthase 2,NONE,P30074,"Secondary metabolites biosynthesis, transport and catabolism",NONE,NONE,,,,"
"
2f57_v,5,2.912,0.5824,0.547934,3,1,1,0,0,0,Serine/threonine-protein kinase PAK 7,TRANSFERASE,PAK7_HUMAN,The activated kinase acts on a variety of targets (By similarity).,NONE,NONE,,,,"
"
2vd1_v,6,3.492,0.582,1.12032,5,1,0,0,0,0,Glutathione-requiring prostaglandin D synthase,ISOMERASE,PTGD2_HUMAN,"Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation.",NONE,NONE,,,,"
"
1yv3_v,6,3.492,0.582,1.52029,4,1,1,0,0,0,Myosin-2 heavy chain,NONE,P08799,"Cell cycle control, cell division, chromosome partitioning",NONE,NONE,,,,"
"
1of6_v,5,2.91,0.582,0.36885,1,3,0,1,0,0,"Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited",NONE,P32449,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1n2j_v,5,2.907,0.5815,0.350705,1,4,0,0,0,0,Pantothenate synthetase,NONE,P0A5R0,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1njr_v,4,2.324,0.581,-0.606047,0,1,3,0,0,0,Uncharacterized protein YML087W,NONE,Q04299,Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. + phosphate.,NONE,NONE,,,,"
"
1h1b_v,6,3.483,0.5806,1.75868,3,3,0,0,0,0,Leukocyte elastase,HYDROLASE(SERINE PROTEASE),ELNE_HUMAN,"Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.","Defects in ELA2 are a cause of cyclic haematopoiesis (CH) [MIM:162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.;Defects in ELA2 are the cause of autosomal dominant severe congenital neutropenia type 1 (SCN1) [MIM:202700]. Severe congenital neutropenia is a heterogeneous disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.",Blood clotting disorder;Chronic bronchitis;Lung injury;Cerebrovascular ischemia;Emphysema;Respiratory disease;Cystic fibrosis;Chronic obstructive pulmonary disease;Myocardial infarction;Lung inflammation;Pulmonary fibrosis;Psoriasis;Pancreatitis;Bronchitis;Rheumatoid arthritis;Arthritis;Pulmonary disease;Lung tumor;Respiratory distress syndrome;Transplant rejection;Pulmonary hypertension;Pneumonia;Inflammation,,,,"
"
1dp2_v,5,2.902,0.5803,0.36596,1,3,0,0,1,0,Thiosulfate sulfurtransferase,NONE,P00586,Involved in thiosulfate sulfurtransferase activity,NONE,NONE,,,,"
"
1tfz_v,6,3.48,0.58,2.07034,3,2,0,0,0,1,4-hydroxyphenylpyruvate dioxygenase,NONE,P93836,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1b3o_v,5,2.9,0.58,0.110548,0,3,1,0,1,0,Inosine-5-monophosphate dehydrogenase 2,DEHYDROGENASE,IMDH2_HUMAN,Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.,NONE,Autoimmune disease;Transplant rejection,,,,"
"
1kto_v,5,2.899,0.5799,0.139664,1,2,1,0,1,0,Bacillolysin,NONE,P43133,Amino acid transport and metabolism,NONE,For the symptomatic relief of patients with interstitial cystitis.,,,,"
"
1mz6_v,5,2.897,0.5794,0.138006,0,2,2,0,1,0,Sialidase,NONE,O44049,Involved in exo-alpha-sialidase activity,NONE,NONE,,,,"
"
1qf3_v,4,2.318,0.5794,-0.830891,0,2,2,0,0,0,Galactose-binding lectin,NONE,P02872,Involved in sugar binding,NONE,NONE,,,,"
"
1ksv_v,5,2.893,0.5786,0.462628,0,4,1,0,0,0,Ribosomal small subunit pseudouridine synthase A,NONE,P0AA43,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
2jfh_v,5,2.891,0.5783,0.339455,2,2,0,0,1,0,UDP-N-acetylmuramoylalanine--D-glutamate ligase,NONE,P14900,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1iub_v,5,2.891,0.5782,0.460917,1,3,1,0,0,0,Fucose-specific lectin,NONE,P18891,Might have a role in the differentiation of cells. Binds L-fucose,NONE,NONE,,,,"
"
1qha_v,5,2.89,0.578,0.257171,0,2,3,0,0,0,Hexokinase-1,TRANSFERASE,HXK1_HUMAN,NONE,Defects in HK1 are the cause of hexokinase deficiency [MIM:235700]. Hexokinase deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature.,NONE,,,,"
"
1rjw_v,4,2.311,0.5779,-0.983244,3,0,1,0,0,0,Alcohol dehydrogenase,NONE,P42328,Involved in zinc ion binding,NONE,NONE,,,,"
"
1sid_v,5,2.889,0.5777,0.176825,0,2,2,0,1,0,Capsid protein VP1,NONE,P49302,Involved in structural molecule activity,NONE,NONE,,,,"
"
1so2_v,5,2.888,0.5775,0.303808,2,2,1,0,0,0,"cGMP-inhibited 3,5-cyclic phosphodiesterase B",HYDROLASE,PDE3B_HUMAN,May play a role in fat metabolism.,NONE,NONE,,,,"
"
2shp_v,5,2.886,0.5773,-0.264862,4,0,0,1,0,0,Tyrosine-protein phosphatase non-receptor type 11,TYROSINE PHOSPHATASE,PTN11_HUMAN,Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.,"Defects in PTPN11 are the cause of LEOPARD syndrome [MIM:151100]. It is an autosomal dominant disorder allelic with Noonan syndrome. The acronym LEOPARD stands for lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and deafness.;Defects in PTPN11 are the cause of Noonan syndrome 1 (NS1) [MIM:163950]. Noonan syndrome (NS) is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Mutations in PTPN11 account for more than 50% of the cases. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS1 inheritance is autosomal dominant.;Defects in PTPN11 are a cause of Noonan-like syndrome [MIM:163955]; also known as Noonan-like/multiple giant cell lesion syndrome. It is an autosomal dominant disorder characterized by Noonan features associates with giant cell lesions of bone and soft tissue.;Defects in PTPN11 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte- macrophage colony stimulating factor.",NONE,,,,"
"
1n8u_v,6,3.462,0.5771,0.860957,5,0,1,0,0,0,Chemosensory protein,NONE,Q9NG96,NONE,NONE,NONE,,,,"
"
1qhs_v,5,2.884,0.5768,0.607481,2,0,3,0,0,0,Chloramphenicol 3-O phosphotransferase,TRANSFERASE,CPT_STRVL,Inactivates chloramphenicol by catalyzing the transfer of the gamma-phosphate of ATP to the antibiotics C-3 hydroxyl group.,NONE,NONE,,,,"
"
1wlj_v,5,2.883,0.5765,-0.0614123,0,4,1,0,0,0,Interferon-stimulated gene 20 kDa protein,HYDROLASE,ISG20_HUMAN,"Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses.",NONE,NONE,,,,"
"
1tc8_v,5,2.879,0.5759,-0.245209,3,2,0,0,0,0,Phospholipase A2 isoform 1,NONE,Q6SLM2,Involved in phospholipase A2 activity,NONE,NONE,,,,"
"
1aua_v,5,2.875,0.5749,-0.103274,3,1,1,0,0,0,SEC14 cytosolic factor,NONE,P24280,Involved in transporter activity,NONE,NONE,,,,"
"
1f92_v,5,2.87,0.574,0.578477,1,2,1,1,0,0,Urokinase-type plasminogen activator,HYDROLASE,UROK_HUMAN,Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.,NONE,Angiogenesis disorder;Ulcer;Cancer;Lung embolism;Restenosis;Metastasis;Skin ulcer;Cardiovascular disease,,,,"
"
1it8_v,5,2.869,0.5739,0.475197,0,2,3,0,0,0,7-cyano-7-deazaguanine tRNA-ribosyltransferase,NONE,O58843,Involved in RNA binding,NONE,NONE,,,,"
"
1pmm_v,6,3.441,0.5735,1.2842,2,3,0,0,1,0,Glutamate decarboxylase beta,NONE,P69910,"Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.",NONE,NONE,,,,"
"
1afw_v,5,2.865,0.5729,0.372148,3,0,2,0,0,0,"3-ketoacyl-CoA thiolase, peroxisomal",NONE,P27796,Lipid transport and metabolism,NONE,NONE,,,,"
"
1hgy_v,5,2.862,0.5723,-0.0464974,0,4,1,0,0,0,Exoglucanase 2,NONE,P07987,"Involved in hydrolase activity, hydrolyzing O-glycosyl compounds",NONE,NONE,,,,"
"
1n5v_v,5,2.861,0.5723,0.0495289,2,3,0,0,0,0,ActVA 6 protein,NONE,Q53908,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1mo9_v,5,2.86,0.5719,-0.0641522,2,2,0,0,1,0,"2-oxopropyl-CoM reductase, carboxylating",NONE,Q56839,Energy production and conversion,NONE,NONE,,,,"
"
1nh8_v,5,2.859,0.5717,-0.15436,0,5,0,0,0,0,ATP phosphoribosyltransferase,NONE,P60759,NONE,NONE,NONE,,,,"
"
1cgh_v,5,2.858,0.5716,0.501718,1,2,0,2,0,0,Cathepsin G,COMPLEX (SERINE PROTEASE/INHIBITOR),CATG_HUMAN,Serine protease with trypsin- and chymotrypsin-like specificity.,NONE,Connective tissue disease;Viral infection;Inflammation;HIV infection,,,,"
"
1b0o_v,6,3.429,0.5715,1.14949,5,0,0,0,1,0,Beta-lactoglobulin,NONE,P02754,Involved in retinoid binding,NONE,NONE,,,,"
"
2csn_v,5,2.857,0.5713,0.382875,2,1,1,1,0,0,Casein kinase I homolog 1,NONE,P40233,Involved in protein kinase activity,NONE,NONE,,,,"
"
1p6d_v,6,3.427,0.5711,1.6246,2,2,0,1,1,0,Phospholipase C,NONE,P09598,"Involved in hydrolase activity, acting on ester bonds",NONE,NONE,,,,"
"
1xo2_v,5,2.855,0.571,0.377821,2,3,0,0,0,0,Cell division protein kinase 6,CELL CYCLE/TRANSFERASE,CDK6_HUMAN,Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.,NONE,NONE,,,,"
"
1fhv_v,6,3.422,0.5703,1.40816,1,3,0,0,2,0,o-succinylbenzoate synthase,NONE,P29208,Involved in magnesium ion binding,NONE,NONE,,,,"
"
1pfv_v,6,3.42,0.57,1.25957,2,3,0,1,0,0,Methionyl-tRNA synthetase,NONE,P00959,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
1u1w_v,4,2.279,0.5698,-1.1342,1,3,0,0,0,0,Phenazine biosynthesis protein phzF,NONE,Q51792,Involved in antibiotic biosynthesis activity,NONE,NONE,,,,"
"
1sz7_v,6,3.417,0.5694,1.03451,5,1,0,0,0,0,Trafficking protein particle complex subunit 3,NONE,O43617,May play a role in vesicular transport from endoplasmic reticulum to Golgi,NONE,NONE,,,,"
"
1nek_v,6,3.415,0.5691,0.507222,5,1,0,0,0,0,Succinate dehydrogenase flavoprotein subunit,NONE,P0AC41,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1ttv_v,6,3.415,0.5691,0.5194,6,0,0,0,0,0,E3 ubiquitin-protein ligase Mdm2,NONE,P56273,Involved in zinc ion binding,NONE,NONE,,,,"
"
2xat_v,5,2.843,0.5686,0.472397,2,2,1,0,0,0,Chloramphenicol acetyltransferase,NONE,P26841,Involved in acyltransferase activity,NONE,"Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.",,,,"
"
1tpy_v,6,3.41,0.5683,0.863485,5,0,0,1,0,0,METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2,NONE,Q79FX6,Involved in cyclopropane-fatty-acyl-phospholipid synthase activity,NONE,NONE,,,,"
"
1u4d_v,5,2.841,0.5683,0.257042,0,2,3,0,0,0,Activated CDC42 kinase 1,TRANSFERASE,ACK1_HUMAN,Downstream effector of CDC42 which mediates CDC42- dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involv,NONE,Cancer,,,,"
"
1uae_v,5,2.841,0.5682,-0.202449,1,2,1,0,1,0,UDP-N-acetylglucosamine 1-carboxyvinyltransferase,TRANSFERASE,MURA_ECOLI,Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine. Target for the antibiotic phosphomycin.,NONE,NONE,,,,"
"
1mn0_v,5,2.839,0.5677,0.0764886,0,3,2,0,0,0,Aldose 1-epimerase,NONE,Q9ZB17,Involved in isomerase activity,NONE,NONE,,,,"
"
1mvn_v,4,2.269,0.5671,-0.801842,1,3,0,0,0,0,Phosphopantothenoylcysteine decarboxylase,NONE,Q9SWE5,"Involved in plant growth and salt and osmotic tolerance. Catalyzes the decarboxylation of 4'-phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis. The enzyme is also able to decarboxylate pantothenoylcysteine to pantothenoylcysteamine.",NONE,NONE,,,,"
"
3cqw_v,5,2.834,0.5669,0.497601,1,2,2,0,0,0,RAC-alpha serine/threonine-protein kinase,TRANSFERASE,AKT1_HUMAN,"General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), e",NONE,Cancer,,,,"
"
2uyo_v,6,3.4,0.5667,1.65621,4,1,1,0,0,0,Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640,NONE,Q9CCZ4,Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.,NONE,NONE,,,,"
"
1seh_v,6,3.4,0.5667,0.606655,1,3,2,0,0,0,Deoxyuridine 5-triphosphate nucleotidohydrolase,NONE,P06968,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1t16_v,6,3.396,0.566,1.17185,4,1,0,1,0,0,Long-chain fatty acid transport protein,NONE,P10384,Lipid transport and metabolism,NONE,NONE,,,,"
"
1bsj_v,6,3.394,0.5657,1.05335,4,2,0,0,0,0,Peptide deformylase,NONE,P0A6K3,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
1djp_v,5,2.828,0.5656,0.532747,1,3,0,1,0,0,Glutaminase-asparaginase,NONE,P10182,NONE,NONE,NONE,,,,"
"
1l5s_v,6,3.39,0.565,1.62597,0,3,3,0,0,0,"Glycogen phosphorylase, liver form",NONE,P06737,Carbohydrate transport and metabolism,NONE,For nutritional supplementation and for treating dietary shortage or imbalance.,,,,"
"
1hk8_v,5,2.825,0.565,-0.507696,0,4,0,0,1,0,Anaerobic ribonucleoside-triphosphate reductase,NONE,P07071,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
2hoh_v,5,2.825,0.565,0.344058,0,4,1,0,0,0,Guanyl-specific ribonuclease T1,NONE,P00651,Involved in RNA binding,NONE,NONE,,,,"
"
1dfq_v,5,2.825,0.5649,-0.254297,0,3,1,0,1,0,Tetanus toxin,NONE,P04958,"Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-",-Phe-77' bond of synaptobrevin-2.,NONE,NONE,,,"
"
1c7z_v,5,2.823,0.5647,-0.336964,0,3,1,0,1,0,"6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1",NONE,P07953,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1nf9_v,6,3.387,0.5645,1.44302,3,1,2,0,0,0,Phenazine biosynthesis protein PhzD,NONE,Q7DC80,Involved in catalytic activity,NONE,NONE,,,,"
"
1ymg_v,5,2.822,0.5645,0.394345,2,0,3,0,0,0,Lens fiber major intrinsic protein,NONE,P06624,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
2fhi_v,5,2.821,0.5643,0.6024,0,3,1,0,0,1,Bis(5-adenosyl)-triphosphatase,NONE,P49789,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1glm_v,4,2.248,0.5621,-1.164,0,1,3,0,0,0,Glucoamylase,NONE,P69327,NONE,NONE,NONE,,,,"
"
1g8i_v,5,2.809,0.5617,0.466772,0,5,0,0,0,0,Neuronal calcium sensor 1,METAL BINDING PROTEIN,NCS1_HUMAN,"Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity).",NONE,NONE,,,,"
"
2bvw_v,5,2.808,0.5616,-0.216367,0,4,1,0,0,0,Exoglucanase-6A,NONE,Q9C1S9,"Involved in hydrolase activity, hydrolyzing O-glycosyl compounds",NONE,NONE,,,,"
"
1x84_v,6,3.368,0.5614,0.770044,2,2,0,0,2,0,Isopentenyl-diphosphate Delta-isomerase,NONE,Q46822,"Secondary metabolites biosynthesis, transport and catabolism",NONE,NONE,,,,"
"
1v9l_v,5,2.805,0.5611,0.435872,1,3,1,0,0,0,Glutamate dehydrogenase,NONE,Q9Y8I4,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
6enl_v,5,2.804,0.5608,-0.433402,0,3,0,0,2,0,Enolase 1,NONE,P00924,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1hmu_v,5,2.804,0.5608,-0.234367,0,2,2,0,1,0,Chondroitinase-AC,NONE,Q59288,Involved in catalytic activity,NONE,NONE,,,,"
"
1m3u_v,5,2.803,0.5606,-0.000660195,1,2,1,0,1,0,3-methyl-2-oxobutanoate hydroxymethyltransferase,NONE,P31057,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
5abp_v,5,2.802,0.5604,-0.418167,0,2,2,0,1,0,L-arabinose-binding periplasmic protein,NONE,P02924,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1bg0_v,5,2.798,0.5595,0.315082,1,2,0,2,0,0,Arginine kinase,NONE,P51541,Involved in kinase activity,NONE,NONE,,,,"
"
1r7t_v,6,3.356,0.5594,1.61394,3,1,2,0,0,0,Histo-blood group ABO system transferase,NONE,P16442,"Involved in transferase activity, transferring hexosyl groups",NONE,NONE,,,,"
"
1u4j_v,4,2.237,0.5592,-1.19385,0,3,1,0,0,0,Phospholipase A2 isoform 2,NONE,Q6SLM1,Involved in phospholipase A2 activity,NONE,NONE,,,,"
"
1yk3_v,5,2.795,0.559,-0.154207,3,2,0,0,0,0,Lysine N-acyltransferase mbtK,NONE,P64820,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
1o6u_v,5,2.794,0.5589,-0.509749,5,0,0,0,0,0,SEC14-like protein 2,NONE,O76054,Involved in transporter activity,NONE,"Vitamin E, known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects. It may be of limited benefit in some with asthma and rheumatoid arthritis. It may be helpful in some neurological diseases including Alzheimers, some eye disorders including cataracts, and diabetes and premenstrual syndrome. It may also help protect skin from ultraviolet irradiation although claims that it reverses skin aging, enhances male fertility and exercise performance are poorly supported. It may help relieve some muscle cramps.",,,,"
"
1yqq_v,4,2.235,0.5588,-0.97583,0,2,2,0,0,0,Xanthosine phosphorylase,NONE,P45563,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1xz8_v,5,2.793,0.5587,0.17238,0,4,1,0,0,0,Bifunctional protein pyrR,NONE,P41007,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1jny_v,5,2.789,0.5579,0.296701,0,2,2,0,1,0,Elongation factor 1-alpha,NONE,P35021,Involved in GTPase activity,NONE,NONE,,,,"
"
1onp_v,5,2.788,0.5577,-0.61214,0,4,0,0,1,0,1-deoxy-D-xylulose 5-phosphate reductoisomerase,NONE,P45568,Lipid transport and metabolism,NONE,NONE,,,,"
"
1i5z_v,4,2.23,0.5575,-1.27003,0,1,3,0,0,0,Catabolite gene activator,NONE,P0ACJ8,Signal transduction mechanisms,NONE,NONE,,,,"
"
1s95_v,4,2.229,0.5571,-1.39118,3,0,1,0,0,0,Serine/threonine-protein phosphatase 5,NONE,P53041,Involved in hydrolase activity,NONE,NONE,,,,"
"
1ne8_v,5,2.784,0.5569,0.394184,0,4,1,0,0,0,Endoribonuclease EndoA,NONE,P96622,Involved in DNA binding,NONE,NONE,,,,"
"
1fiy_v,5,2.784,0.5568,-0.188993,0,2,1,0,2,0,Phosphoenolpyruvate carboxylase,NONE,P00864,Energy production and conversion,NONE,NONE,,,,"
"
1mw1_v,6,3.34,0.5566,1.74156,0,3,3,0,0,0,Amylosucrase,NONE,Q9ZEU2,Involved in catalytic activity,NONE,NONE,,,,"
"
2rku_v,4,2.227,0.5566,-1.05118,2,1,1,0,0,0,Serine/threonine-protein kinase PLK1,NONE,P53350,"Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143).",NONE,NONE,,,,"
"
1i72_v,4,2.225,0.5563,-0.637108,0,3,1,0,0,0,S-adenosylmethionine decarboxylase proenzyme,LYASE,DCAM_HUMAN,NONE,NONE,Colorectal tumor;Non-Hodgkin lymphoma;Neoplasm;Cancer;Trypanosomiasis;Pneumocystis carinii infection;Bacterial infection,,,,"
"
1rzm_v,5,2.778,0.5556,-0.374338,1,2,0,0,2,0,Phospho-2-dehydro-3-deoxyheptonate aldolase,NONE,Q9WYH8,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1fvo_v,5,2.777,0.5554,-0.391051,0,2,1,0,2,0,"Ornithine carbamoyltransferase, mitochondrial",NONE,P00480,Amino acid transport and metabolism,NONE,"Used for nutritional supplementation, also for treating dietary shortage or imbalance. It has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing.",,,,"
"
2j7x_v,4,2.222,0.5554,-1.02137,2,1,1,0,0,0,Estrogen receptor beta,NONE,Q62986,Involved in transcription factor activity,NONE,NONE,,,,"
"
1jpc_v,5,2.776,0.5552,-0.274119,0,3,2,0,0,0,Mannose-specific lectin,NONE,P30617,Involved in sugar binding,NONE,NONE,,,,"
"
1qdd_v,5,2.776,0.5552,0.24509,0,4,1,0,0,0,Lithostathine-1-alpha,NONE,P05451,Involved in sugar binding,NONE,NONE,,,,"
"
1v2f_v,5,2.775,0.555,-0.102607,2,1,0,0,1,1,Aminotransferase,NONE,Q75WK2,"Involved in transferase activity, transferring nitrogenous groups",NONE,NONE,,,,"
"
1r1o_v,5,2.774,0.5547,0.0157133,1,2,1,1,0,0,Arginase-1,NONE,P07824,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1umz_v,5,2.771,0.5541,0.193818,0,5,0,0,0,0,Xyloglucan endotransglycosylase,NONE,Q8GZD5,"Involved in hydrolase activity, hydrolyzing O-glycosyl compounds",NONE,NONE,,,,"
"
1y89_v,5,2.767,0.5535,0.406537,0,5,0,0,0,0,DevB protein,NONE,Q9KL51,Involved in 6-phosphogluconolactonase activity,NONE,NONE,,,,"
"
1icp_v,5,2.766,0.5532,0.535555,0,4,1,0,0,0,12-oxophytodienoate reductase 1,NONE,Q9XG54,Energy production and conversion,NONE,NONE,,,,"
"
1u59_v,7,3.871,0.5529,2.21177,4,1,2,0,0,0,Tyrosine-protein kinase ZAP-70,TRANSFERASE,ZAP70_HUMAN,"Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.",Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.,Transplant rejection;Immune disorder,,,,"
"
1ikh_v,7,3.87,0.5528,1.66579,5,1,1,0,0,0,Nitrophorin-4,NONE,Q94734,Involved in histamine and NO binding,NONE,NONE,,,,"
"
1ewo_v,5,2.762,0.5523,0.145317,2,2,1,0,0,0,Cruzipain,NONE,P25779,Involved in cysteine-type endopeptidase activity,NONE,NONE,,,,"
"
1kyw_v,5,2.761,0.5522,-0.454535,2,1,0,1,1,0,Caffeic acid 3-O-methyltransferase,NONE,P28002,"Secondary metabolites biosynthesis, transport and catabolism",NONE,NONE,,,,"
"
1iw0_v,5,2.76,0.5521,0.159982,0,3,2,0,0,0,Heme oxygenase,NONE,P71119,Involved in heme oxygenase (decyclizing) activity,NONE,NONE,,,,"
"
1mvq_v,5,2.759,0.5518,0.0911534,0,2,3,0,0,0,Mannose/glucose-specific lectin Cramoll,NONE,P83721,Involved in sugar binding,NONE,NONE,,,,"
"
1i53_v,5,2.758,0.5517,0.288476,5,0,0,0,0,0,Azurin,NONE,P00282,Energy production and conversion,NONE,NONE,,,,"
"
1yw1_v,5,2.758,0.5517,-0.29555,0,4,1,0,0,0,Putative monooxygenase moxC,NONE,O34974,Energy production and conversion,NONE,NONE,,,,"
"
1sdw_v,5,2.754,0.5508,-0.0580604,3,1,0,0,0,1,Peptidyl-glycine alpha-amidating monooxygenase,NONE,P19021,Bifunctional enzyme that catalyzes 2 sequencial steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity,NONE,"Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.",,,,"
"
1rk2_v,5,2.754,0.5508,0.00367586,0,1,4,0,0,0,Ribokinase,NONE,P0A9J6,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1hkv_v,5,2.753,0.5506,-0.5188,1,2,0,0,1,1,Diaminopimelate decarboxylase,NONE,P0A5M4,NONE,NONE,NONE,,,,"
"
1qmg_v,6,3.301,0.5501,1.42874,2,3,1,0,0,0,"Ketol-acid reductoisomerase, chloroplast",NONE,Q01292,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1ee2_v,6,3.3,0.5499,1.4382,3,1,1,0,1,0,Alcohol dehydrogenase S chain,NONE,P00328,Energy production and conversion,NONE,NONE,,,,"
"
1mwq_v,5,2.749,0.5497,0.246774,0,5,0,0,0,0,Protein HI0828,NONE,P44887,NONE,NONE,NONE,,,,"
"
1xqk_v,5,2.747,0.5493,-0.130511,1,2,0,1,1,0,Alanine racemase,NONE,P10724,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1c41_v,6,3.292,0.5487,1.52169,0,3,3,0,0,0,"6,7-dimethyl-8-ribityllumazine synthase",NONE,Q9UVT8,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1j2r_v,5,2.743,0.5485,-0.19819,3,1,1,0,0,0,Isochorismatase family protein yecD,NONE,P0ADI7,"Secondary metabolites biosynthesis, transport and catabolism",NONE,NONE,,,,"
"
1u3w_v,5,2.742,0.5484,-0.31374,3,1,0,1,0,0,Alcohol dehydrogenase 1C,NONE,P00326,Energy production and conversion,NONE,"Some evidence suggests that NADH might be useful in treating Parkinsons disease, chronic fatigue syndrome, Alzheimers disease and cardiovascular disease.",,,,"
"
1sde_v,5,2.741,0.5483,-0.277031,1,2,0,0,2,0,D-alanyl-D-alanine carboxypeptidase,NONE,P15555,Involved in cell wall peptidoglycan synthesis,NONE,"Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.",,,,"
"
1wvj_v,5,2.741,0.5482,-0.451272,1,2,0,1,1,0,Glutamate receptor 2,MEMBRANE PROTEIN,GRIA2_RAT,"Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation c",NONE,NONE,,,,"
"
1p42_v,7,3.834,0.5477,1.38981,5,1,0,0,1,0,UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase,NONE,O67648,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1uhl_v,6,3.286,0.5477,0.954283,5,1,0,0,0,0,Oxysterols receptor LXR-alpha,DNA BINDING PROTEIN,NR1H3_HUMAN,Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized b,NONE,NONE,,,,"
"
1muu_v,5,2.736,0.5471,-0.315221,0,3,2,0,0,0,GDP-mannose 6-dehydrogenase,NONE,P11759,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1rmy_v,5,2.733,0.5465,0.0833331,1,2,2,0,0,0,Class B acid phosphatase,NONE,P0AE22,Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3- and 5-nucleotides and also additional organic phosphomonoesters,NONE,NONE,,,,"
"
1j37_v,5,2.732,0.5464,-0.384001,2,1,0,1,1,0,Angiotensin-converting enzyme,NONE,Q10714,Involved in metallopeptidase activity,NONE,NONE,,,,"
"
1hql_v,5,2.731,0.5461,-0.215757,0,2,3,0,0,0,GSI-B4 isolectin,NONE,Q8W1R6,Involved in sugar binding,NONE,NONE,,,,"
"
1ujp_v,5,2.73,0.5461,-0.662946,0,5,0,0,0,0,Tryptophan synthase alpha chain,NONE,P16608,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1yvj_v,6,3.272,0.5453,0.864685,4,1,1,0,0,0,Tyrosine-protein kinase JAK3,TRANSFERASE,JAK3_HUMAN,"Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K.","Defects in JAK3 are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell- positive/NK-cell-negative (T(-)B(+)NK(-)SCID) [MIM:600802]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.",Psoriasis;Transplant rejection;Rheumatoid arthritis;Respiratory tract inflammation;Autoimmune disease,,,,"
"
1a6w_v,6,3.27,0.5449,1.6048,2,3,0,0,0,1,Ig heavy chain V region B1-8/186-2,NONE,P01751,"blood microparticle, external side of plasma membrane, immunoglobulin complex, circulating, antigen binding, immunoglobulin receptor binding, B cell receptor signaling pathway, complement activation, classical pathway, defense response to bacterium, innate immune response, phagocytosis, engulfment",NONE,NONE,,,,"
"
1qab_v,6,3.269,0.5449,0.838659,5,0,1,0,0,0,Retinol-binding protein 4,TRANSPORT PROTEIN,RET4_HUMAN,"Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.","Defects in RBP4 are a cause of retinol-binding protein deficiency [MIM:180250]. This condition causes night vision problems. It produces a typical fundus xerophthalmicus, featuring a progressed atrophy of the retinal pigment epithelium.;A deficiency of vitamin A blocks secretion of the binding protein post-translationally and results in defective delivery and supply of vitamin to the epidermal cells (a condition associated with a dermatosis).",NONE,,,,"
"
1aqf_v,5,2.724,0.5447,-0.473093,1,2,0,0,2,0,Pyruvate kinase isozymes M1/M2,NONE,P11974,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1hze_v,6,3.267,0.5445,1.20002,2,3,1,0,0,0,Riboflavin synthase alpha chain,TRANSFERASE,RISA_ECOLI,"Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze",NONE,NONE,,,,"
"
3d7t_v,6,3.264,0.544,1.06303,3,1,1,1,0,0,Tyrosine-protein kinase CSK,TRANSFERASE,CSK_HUMAN,"Specifically phosphorylates Tyr-504 on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.",NONE,NONE,,,,"
"
1mn2_v,5,2.718,0.5436,-0.0729512,0,4,1,0,0,0,Peroxidase manganese-dependent 1,NONE,Q02567,"Catalyzes the oxidation of Mn(2+) to Mn(3+). The latter, acting as a diffusible redox mediator, is capable of oxidizing a variety of lignin compounds.",NONE,NONE,,,,"
"
1efi_v,5,2.714,0.5428,-0.200227,0,3,2,0,0,0,Heat-labile enterotoxin B chain,NONE,P32890,"The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase",NONE,NONE,,,,"
"
1iyl_v,5,2.71,0.542,-0.523735,4,0,0,1,0,0,Glycylpeptide N-tetradecanoyltransferase,NONE,P30418,Involved in glycylpeptide N-tetradecanoyltransferase activity,NONE,NONE,,,,"
"
1uyr_v,6,3.247,0.5411,0.551772,5,1,0,0,0,0,Acetyl-CoA carboxylase,NONE,Q00955,Lipid transport and metabolism,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1j09_v,5,2.704,0.5408,-0.395323,0,3,0,1,1,0,Glutamyl-tRNA synthetase,NONE,P27000,Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).,NONE,NONE,,,,"
"
2hmb_v,7,3.78,0.54,1.25792,5,1,0,0,1,0,"Fatty acid-binding protein, heart",LIPID-BINDING PROTEIN,FABPH_HUMAN,FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.,NONE,NONE,,,,"
"
1pbq_v,6,3.24,0.54,1.14785,2,2,1,0,1,0,Glutamate [NMDA] receptor subunit zeta-1,NONE,P35439,"NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.",NONE,NONE,,,,"
"
1rkp_v,4,2.157,0.5393,-1.07409,1,2,0,0,0,1,"cGMP-specific 3,5-cyclic phosphodiesterase",HYDROLASE,PDE5A_HUMAN,Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5- GMP.,NONE,Anal fissure;Raynauds disease;Cardiac failure;Thrombosis;Diabetic complication;Prostate hyperplasia;Erectile dysfunction;Urinary tract disease;Female sexual dysfunction;Vascular disease;Viral infection;Cancer;Atherosclerosis;Pulmonary disease;Metabolic disorder;Hypertension;Cardiovascular disease;Pulmonary hypertension;Angina;Male sexual dysfunction,,,,"
"
1o1v_v,7,3.772,0.5389,1.35284,5,1,1,0,0,0,Gastrotropin,LIPID BINDING PROTEIN,FABP6_HUMAN,Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins.,NONE,NONE,,,,"
"
1dia_v,6,3.23,0.5383,1.46437,2,2,2,0,0,0,"C-1-tetrahydrofolate synthase, cytoplasmic",NONE,P11586,Nucleotide transport and metabolism,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance.",,,,"
"
1wuw_v,4,2.149,0.5373,-2.09643,2,1,0,0,1,0,Beta-hordothionin,NONE,P21742,Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known,NONE,NONE,,,,"
"
3eng_v,5,2.684,0.5368,-0.173841,0,5,0,0,0,0,Endoglucanase-5,NONE,P43316,Involved in cellulase activity,NONE,NONE,,,,"
"
1iri_v,7,3.755,0.5365,1.18584,0,6,1,0,0,0,Glucose-6-phosphate isomerase,ISOMERASE,G6PI_HUMAN,Neurotrophic factor for spinal and sensory neurons.,"Defects in GPI are a cause of hereditary nonspherocytic hemolytic anemia (HA) [MIM:172400]. Severe GPI deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.",NONE,,,,"
"
1uou_v,4,2.145,0.5363,-0.690016,1,0,3,0,0,0,Thymidine phosphorylase,TRANSFERASE,TYPH_HUMAN,"May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.;Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.","Defects in TYMP are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) [MIM:603041]; also known as myoneurogastrointestinal encephalomyopathy. MNGIE is an autosomal recessive disease associated with multiple deletions of skeletal muscle mitochondrial DNA (MtDNA). It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, thin body habitus, peripheral neuropathy, and myopathy.",Angiogenesis disorder;Cancer,,,,"
"
1dku_v,5,2.681,0.5362,-0.00969235,0,3,1,0,1,0,Ribose-phosphate pyrophosphokinase,NONE,P14193,"Posttranslational modification, protein turnover, chaperones",NONE,NONE,,,,"
"
1tlz_v,4,2.143,0.5358,-1.40245,0,3,0,0,0,1,Nucleoside-specific channel-forming protein tsx precursor,NONE,P0A927,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1w8b_v,5,2.675,0.5351,-0.0937915,2,0,1,1,1,0,Coagulation factor VII,HYDROLASE,FA7_HUMAN,"Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue","Defects in F7 are the cause of factor VII deficiency [MIM:227500]. Factor VII deficiency is a rare hereditary hemorrhagic disease. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Numerous subjects are completely asymptomatic despite a very low F7 level.",Deep vein thrombosis;Blood clotting disorder;Cancer;Ebola virus infection;Thrombosis;Lung embolism;Unstable angina;Angina;Myocardial infarction;Thromboembolism;Cardiovascular disease,,,,"
"
1lfo_v,7,3.745,0.535,1.59887,5,1,0,0,1,0,"Fatty acid-binding protein, liver",NONE,P02692,Involved in fatty acid binding,NONE,NONE,,,,"
"
1w55_v,5,2.675,0.535,-0.745574,0,3,1,0,1,0,Bifunctional enzyme ispD/ispF,NONE,Q9PM68,Lipid transport and metabolism,NONE,NONE,,,,"
"
1dqe_v,6,3.21,0.5349,0.47918,5,1,0,0,0,0,Pheromone-binding protein,NONE,P34174,Involved in odorant binding,NONE,NONE,,,,"
"
1k0e_v,5,2.673,0.5346,0.0533652,1,2,1,1,0,0,Para-aminobenzoate synthase component 1,LYASE,PABB_ECOLI,Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine.,NONE,NONE,,,,"
"
1fbp_v,5,2.67,0.534,0.0145698,1,2,1,0,1,0,"Fructose-1,6-bisphosphatase 1",NONE,P00636,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1gt7_v,5,2.67,0.534,-0.541422,0,4,1,0,0,0,Rhamnulose-1-phosphate aldolase,NONE,P32169,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1k1w_v,4,2.135,0.5337,-1.17022,0,0,4,0,0,0,4-alpha-glucanotransferase,NONE,O32462,Involved in catalytic activity,NONE,NONE,,,,"
"
1y79_v,5,2.667,0.5333,-0.598048,0,3,0,0,2,0,Peptidyl-dipeptidase dcp,NONE,P24171,"Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides.",NONE,NONE,,,,"
"
1xey_v,6,3.199,0.5332,0.526871,2,3,0,0,1,0,Glutamate decarboxylase alpha,NONE,P69908,Involved in glutamate decarboxylase activity,NONE,NONE,,,,"
"
1awb_v,6,3.199,0.5332,-0.189635,0,3,2,0,1,0,Inositol monophosphatase,HYDROLASE,IMPA1_HUMAN,Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain.,The blockade of inositol monophosphatase hydrolysis may underlie the anti-manic and anti-depressant actions of Li(+).,NONE,,,,"
"
2gbp_v,6,3.198,0.5331,0.300795,0,5,1,0,0,0,D-galactose-binding periplasmic protein precursor,NONE,P0AEE5,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1gsf_v,8,4.262,0.5327,2.63048,5,3,0,0,0,0,Glutathione S-transferase A1,NONE,P08263,Involved in glutathione transferase activity,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1s2p_v,5,2.662,0.5324,-0.36768,3,2,0,0,0,0,Crustacyanin-A1 subunit,NONE,P58989,Involved in binding,NONE,NONE,,,,"
"
1hx1_v,4,2.129,0.5323,-1.21594,0,1,2,1,0,0,BAG family molecular chaperone regulator 1,CHAPERONE/CHAPERONE INHIBITOR,BAG1_HUMAN,"Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.","May be linked to the cryptophthalmos syndrome (Fraser syndrome), an autosomal recessive disorder characterized by the failure of eyes fissures to form during embryogenesis, webbed fingers, and atresia of ear canals, anus, vagina, alimentary tract, or larynx. All these developmental processes require cell death.",NONE,,,,"
"
1d2a_v,4,2.129,0.5321,-1.79022,0,2,2,0,0,0,Low molecular weight phosphotyrosine protein phosphatase,HYDROLASE,PPAL_YEAST,"Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates (By similarity).",NONE,NONE,,,,"
"
1ecc_v,5,2.658,0.5316,-0.516277,1,2,0,1,1,0,Amidophosphoribosyltransferase,NONE,P0AG16,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1oec_v,5,2.658,0.5315,-0.748779,3,1,0,1,0,0,Fibroblast growth factor receptor 2,NONE,P21802,Involved in protein kinase activity,NONE,For treatment of mucositis (mouth sores),,,,"
"
2b7a_v,7,3.72,0.5314,1.69671,3,2,2,0,0,0,Tyrosine-protein kinase JAK2,TRANSFERASE,JAK2_HUMAN,"Plays a role in leptin signaling and control of body weight (By similarity). Tyrosine kinase of the non-receptor type, involved in interleukin-3 and probably interleukin-23 signal transduction.","Chromosomal aberrations involving JAK2 are found in both chronic and acute forms of eosinophilic, lymphoblastic and myeloid leukemia. Translocation t(8;9)(p22;p24) with PCM1 links the protein kinase domain of JAK2 to the major portion of PCM1. Translocation t(9;12)(p24;p13) with ETV6.;Defects in JAK2 are a cause of susceptibility to Budd- Chiari syndrome [MIM:600880]. Budd-Chiari syndrome is a spectrum of disease states, including anatomic abnormalities and hypercoagulable disorders, resulting in hepatic venous outflow occlusion. Clinical manifestations observed in the majority of patients include hepatomegaly, right upper quadrant pain, and abdominal ascites.;Defects in JAK2 are associated with polycythemia vera (PV) [MIM:263300]. PV, the most common form of primary polycythemia, is caused by somatic mutation in a single hematopoietic stem cell leading to clonal hematopoiesis. PV is a myeloproliferative disorder characterized predominantly by erythroid hyperplasia, but also by myeloid leukocytosis, thrombocytosis, and splenomegaly. Familial cases of PV are very rare and usually manifest in elderly patients.;Defects in JAK2 gene may be a cause of essential thrombocythemia (ET) [MIM:187950]. ET is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.;Defects in JAK2 are associated with familial myelofibrosis [MIM:254450]. Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of 0.5-1.5 cases per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.;Defects in JAK2 are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.",Psoriasis;Cancer;Rheumatoid arthritis;Pulmonary hypertension;Myeloid leukemia;Inflammation;Prostate tumor;Pancreas tumor;Myeloproliferative disorder;Solid tumor;Myelofibrosis;Hematological neoplasm;Cardiovascular disease,,,,"
"
2nn7_v,4,2.121,0.5302,-1.37854,2,1,1,0,0,0,Carbonic anhydrase 1,LYASE,CAH1_HUMAN,Reversible hydration of carbon dioxide.,NONE,NONE,,,,"
"
1dcp_v,5,2.649,0.5298,-0.609814,0,3,2,0,0,0,Pterin-4-alpha-carbinolamine dehydratase,NONE,P61459,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1kph_v,6,3.173,0.5289,0.391664,1,4,1,0,0,0,Cyclopropane-fatty-acyl-phospholipid synthase 1,NONE,Q11195,Cell wall/membrane/envelope biogenesis,NONE,For the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents.,,,,"
"
1hv5_v,7,3.702,0.5288,2.01322,4,1,2,0,0,0,Stromelysin-3,NONE,Q02853,Involved in protease activity,NONE,NONE,,,,"
"
3cpu_v,5,2.644,0.5288,-0.165516,0,2,3,0,0,0,Pancreatic alpha-amylase,HYDROLASE,AMYP_HUMAN,NONE,NONE,Bacillus anthracis infection,,,,"
"
1d7s_v,6,3.172,0.5286,-0.00323533,1,4,1,0,0,0,"2,2-dialkylglycine decarboxylase",NONE,P16932,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1tw5_v,5,2.641,0.5281,-0.467615,0,4,1,0,0,0,"Beta-1,4-galactosyltransferase 1",NONE,P08037,The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.,NONE,NONE,,,,"
"
2cbf_v,7,3.686,0.5266,2.18861,2,3,2,0,0,0,Cobalt-precorrin-4 C(11)-methyltransferase,NONE,O87696,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1p5z_v,5,2.632,0.5264,-0.0813438,1,1,3,0,0,0,Deoxycytidine kinase,TRANSFERASE,DCK_HUMAN,"Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemothera",NONE,NONE,,,,"
"
1e55_v,6,3.158,0.5263,0.822034,2,1,3,0,0,0,"Beta-glucosidase, chloroplastic",NONE,P49235,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1mxb_v,5,2.629,0.5258,-0.44085,0,2,1,0,2,0,S-adenosylmethionine synthetase,NONE,P0A817,"Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (PubMed:6251075, PubMed:7629147, PubMed:7629176, PubMed:9753435, PubMed:10551856, PubMed:10660564). Is essential for growth (PubMed:11952912).",NONE,NONE,,,,"
"
1jys_v,5,2.623,0.5247,-0.724631,0,3,2,0,0,0,5-methylthioadenosine/S-adenosylhomocysteine nucleosidase,HYDROLASE,MTNN_ECOLI,"Catalyzes the irreversible cleavage of the glycosidic bond in both 5-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5-methylthioribose and S-ribosylhomocysteine, respectively. Can also use",NONE,Bacterial infection,,,,"
"
1c7t_v,5,2.62,0.5239,-0.481501,0,2,3,0,0,0,Chitobiase,NONE,Q54468,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1nav_v,7,3.664,0.5235,1.36713,4,2,1,0,0,0,Thyroid hormone receptor alpha,NONE,P10827,Involved in transcription factor activity,NONE,"Used as replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyrodism during the recovery phase of subacute thyroiditis.",,,,"
"
1qfx_v,5,2.614,0.5229,-0.311351,0,4,1,0,0,0,3-phytase B,NONE,P34755,Involved in acid phosphatase activity,NONE,NONE,,,,"
"
1yg9_v,5,2.613,0.5227,-0.434315,0,4,1,0,0,0,Aspartic protease Bla g 2,NONE,P54958,Involved in aspartic-type endopeptidase activity,NONE,NONE,,,,"
"
1aqu_v,8,4.18,0.5225,0.999566,5,2,1,0,0,0,"Estrogen sulfotransferase, testis isoform",NONE,P49891,Involved in sulfotransferase activity,NONE,NONE,,,,"
"
1oix_v,6,3.133,0.5222,0.974373,0,2,4,0,0,0,Ras-related protein Rab-11A,PROTEIN TRANSPORT,RB11A_HUMAN,Modulates endosomal trafficking (By similarity).,NONE,NONE,,,,"
"
1op0_v,4,2.087,0.5217,-1.01705,1,0,3,0,0,0,Venom serine proteinase Dav-PA,NONE,Q9I8X1,Involved in catalytic activity,NONE,NONE,,,,"
"
1q13_v,7,3.65,0.5214,0.772476,6,1,0,0,0,0,Prostaglandin-E(2) 9-reductase,NONE,P80508,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1ne7_v,7,3.648,0.5212,2.42696,0,4,3,0,0,0,Glucosamine-6-phosphate isomerase,NONE,P46926,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1dnp_v,5,2.605,0.5211,-0.395858,1,1,2,0,1,0,Deoxyribodipyrimidine photo-lyase,NONE,P00914,Involved in DNA photolyase activity,NONE,NONE,,,,"
"
1vk5_v,8,4.166,0.5207,1.62322,7,0,1,0,0,0,Protein At3g22680,NONE,Q9LUJ3,"Regulator of RNA-directed DNA methylation (RdDM). Binds to single-stranded methyl DNA. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex.",NONE,NONE,,,,"
"
1s3f_v,4,2.083,0.5207,-1.58713,0,2,2,0,0,0,Purine trans deoxyribosylase,NONE,Q8RLY5,Nucleotide transport and metabolism,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1jvi_v,8,4.158,0.5198,2.54982,2,2,2,1,1,0,S-ribosylhomocysteine lyase,NONE,O34667,Signal transduction mechanisms,NONE,NONE,,,,"
"
1fe3_v,7,3.638,0.5197,0.895909,6,0,0,0,1,0,"Fatty acid-binding protein, brain",LIPID BINDING PROTEIN,FABP7_HUMAN,"B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necess",NONE,NONE,,,,"
"
1ve6_v,7,3.625,0.5179,1.87857,3,2,2,0,0,0,Acylamino-acid-releasing enzyme,NONE,Q9YBQ2,Amino acid transport and metabolism,NONE,NONE,,,,"
"
2wea_v,7,3.625,0.5178,0.497081,3,3,1,0,0,0,Penicillopepsin,NONE,P00798,Involved in aspartic-type endopeptidase activity,NONE,NONE,,,,"
"
1drj_v,5,2.587,0.5174,-0.560184,0,3,2,0,0,0,D-ribose-binding periplasmic protein,NONE,P02925,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1r6n_v,8,4.136,0.517,2.42863,5,3,0,0,0,0,Regulatory protein E2,NONE,P04015,Involved in nucleotide binding,NONE,For the symptomatic relief of patients with interstitial cystitis.,,,,"
"
1cwv_v,5,2.585,0.517,-0.991426,0,3,1,0,1,0,Invasin,NONE,P11922,Involved in binding,NONE,NONE,,,,"
"
1ywq_v,6,3.099,0.5165,1.01407,2,3,0,1,0,0,Nitroreductase family protein,NONE,Q81EW9,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1jvn_v,5,2.582,0.5164,-0.907577,0,4,0,0,1,0,Imidazole glycerol phosphate synthase hisHF,NONE,P33734,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1zhy_v,9,4.633,0.5148,1.8948,9,0,0,0,0,0,Protein KES1,NONE,P35844,"Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum (PubMed:16136145, PubMed:22162133). Displays a similar affinity for PI4P and sterols (PubMed:22162133). Binds sterol and PI4P in a mutually exclusive manner (Probable).",NONE,NONE,,,,"
"
1tky_v,5,2.573,0.5145,-0.10366,0,2,2,1,0,0,Threonyl-tRNA synthetase,NONE,P0A8M3,"ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.",NONE,NONE,,,,"
"
1t5d_v,4,2.058,0.5145,-2.21092,2,1,0,0,1,0,4-chlorobenzoyl CoA ligase,NONE,Q8GN86,Involved in catalytic activity,NONE,NONE,,,,"
"
1qzr_v,5,2.572,0.5144,-0.259973,1,0,2,2,0,0,DNA topoisomerase 2,NONE,P06786,"Replication, recombination and repair",NONE,NONE,,,,"
"
1pvj_v,5,2.569,0.5137,-0.562719,2,2,0,1,0,0,Streptopain,NONE,P0C0J0,"Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing",NONE,NONE,,,,"
"
1qit_v,7,3.595,0.5136,1.0533,2,3,1,0,1,0,Aspartate aminotransferase,NONE,P00509,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1iz2_v,6,3.081,0.5135,0.656445,3,1,2,0,0,0,Alpha-1-antitrypsin,PROTEIN BINDING,A1AT_HUMAN,"Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, de","The major physiological function of AAT is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). A hereditary deficiency of AAT, is associated with a 20-30 fold increased risk of developing chronic obstructive pulmonary disease.;Deficiency of the normal inhibitor in individuals homozygous for allele Z or M-Malton can result in the development of chronic emphysema or infantile liver cirrhosis.;Variant Pittsburgh is the cause of bleeding diathesis.",Psoriasis;Genital tract inflammation;Otitis media;Wound healing;Atopic dermatitis;Dermatitis;Cystitis;Inflammatory bowel disease;Cystic fibrosis;Alpha-1 antitrypsin deficiency;Dermatological disease,,,,"
"
1q44_v,4,2.052,0.513,-2.23197,0,4,0,0,0,0,Flavonol sulfotransferase-like,NONE,P52839,Involved in sulfotransferase activity,NONE,NONE,,,,"
"
1muq_v,5,2.563,0.5126,-0.832047,0,2,3,0,0,0,Galactose-specific lectin,NONE,P21963,Involved in sugar binding,NONE,NONE,,,,"
"
1xjd_v,7,3.577,0.5109,1.31963,4,1,1,1,0,0,Protein kinase C theta type,TRANSFERASE,KPCT_HUMAN,"This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to;PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.",NONE,Inflammation,,,,"
"
1hzl_v,5,2.554,0.5108,-0.159168,0,3,0,2,0,0,Antitumor antibiotic C-1027 apoprotein,NONE,Q06110,Involved in DNA binding,NONE,NONE,,,,"
"
1izo_v,7,3.572,0.5103,1.14357,5,1,0,0,1,0,Cytochrome P450 152A1,NONE,O31440,"Secondary metabolites biosynthesis, transport and catabolism",NONE,NONE,,,,"
"
2q6c_v,5,2.551,0.5103,-0.783512,2,2,0,0,1,0,3-hydroxy-3-methylglutaryl-coenzyme A reductase,OXIDOREDUCTASE,HMDH_HUMAN,This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.,NONE,Alzheimers disease;Renal disease;Lipid metabolism disorder;Cardiac failure;Hyperlipidemia;Intermittent claudication;Myocardial infarction;Coronary artery disease;Glioma;Hypercholesterolemia;Atherosclerosis;Peripheral arterial occlusive disease;Cardiovascular disease;Congestive heart failure;Angina;Hypertension;Heart disease;Cerebrovascular ischemia;Osteoporosis,,,,"
"
1ds6_v,5,2.55,0.5101,-0.44274,0,3,2,0,0,0,Ras-related C3 botulinum toxin substrate 2,NONE,P15153,"Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.",NONE,NONE,,,,"
"
1u4o_v,5,2.55,0.51,-0.703539,1,4,0,0,0,0,L-lactate dehydrogenase,NONE,Q27743,Energy production and conversion,NONE,NONE,,,,"
"
1gp4_v,5,2.549,0.5097,-1.02974,0,3,0,0,2,0,Leucoanthocyanidin dioxygenase,NONE,Q96323,Involved in leucocyanidin oxygenase activity,NONE,NONE,,,,"
"
1jsr_v,5,2.546,0.5092,-0.393274,1,3,0,1,0,0,L-asparaginase,NONE,P06608,Amino acid transport and metabolism,NONE,NONE,,,,"
"
3dy6_v,4,2.035,0.5088,-2.23376,3,1,0,0,0,0,Peroxisome proliferator-activated receptor delta,NONE,Q03181,Involved in DNA binding,NONE,"EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.",,,,"
"
1q22_v,7,3.56,0.5086,0.898291,6,1,0,0,0,0,Sulfotransferase family cytosolic 2B member 1,NONE,O00204,Involved in sulfotransferase activity,NONE,NONE,,,,"
"
1lp6_v,6,3.049,0.5082,0.593216,1,5,0,0,0,0,Orotidine 5-phosphate decarboxylase,NONE,O26232,Energy production and conversion,NONE,NONE,,,,"
"
1ewk_v,5,2.541,0.5082,-0.680484,0,3,0,1,1,0,Metabotropic glutamate receptor 1,NONE,P23385,"G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.",NONE,NONE,,,,"
"
11bg_v,6,3.047,0.5079,0.668107,0,3,3,0,0,0,Seminal ribonuclease,NONE,P00669,Involved in nucleic acid binding,NONE,NONE,,,,"
"
1zzd_v,4,2.031,0.5077,-1.72706,2,2,0,0,0,0,Ribonucleoside-diphosphate reductase large chain 1,NONE,P21524,Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.,NONE,NONE,,,,"
"
1j0n_v,7,3.549,0.5071,1.15362,0,6,0,0,1,0,Xanthan lyase,NONE,Q9AQS0,Involved in catalytic activity,NONE,NONE,,,,"
"
1mka_v,6,3.039,0.5066,0.42142,3,2,1,0,0,0,3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase,NONE,P0A6Q3,"Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. Is inactive in the dehydration of long chain unsaturated beta-hydroxyacyl-ACP.",NONE,NONE,,,,"
"
1u80_v,6,3.035,0.5059,0.632231,1,2,2,0,1,0,Coenzyme A biosynthesis bifunctional protein coaBC,NONE,P0ABQ0,Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11278255). In the second the latter compound is decarboxylated to form 4'-phosphopantotheine (PubMed:10922366).,NONE,NONE,,,,"
"
1rfu_v,7,3.54,0.5057,1.25763,2,4,0,0,1,0,Pyridoxal kinase,NONE,P82197,Required for synthesis of pyridoxal-5-phosphate from vitamin B6.,NONE,NONE,,,,"
"
1qz3_v,7,3.538,0.5054,1.19442,5,2,0,0,0,0,Hydrolase,NONE,Q7SIG1,Involved in hydrolase activity,NONE,NONE,,,,"
"
1mu0_v,5,2.527,0.5054,-0.630198,3,1,0,1,0,0,Proline iminopeptidase,NONE,P96084,Involved in hydrolase activity,NONE,NONE,,,,"
"
1jxa_v,6,3.03,0.505,0.668803,1,4,1,0,0,0,Glucosamine--fructose-6-phosphate aminotransferase [isomerizing],NONE,P17169,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1e5i_v,5,2.519,0.5037,-1.14584,0,2,1,0,2,0,Deacetoxycephalosporin C synthetase,NONE,P18548,Involved in iron ion binding,NONE,NONE,,,,"
"
1n6i_v,6,3.021,0.5036,0.807955,0,2,4,0,0,0,Ras-related protein Rab-5A,PROTEIN TRANSPORT,RAB5A_HUMAN,Required for the fusion of plasma membranes and early endosomes.,NONE,NONE,,,,"
"
1o5p_v,7,3.523,0.5033,0.836116,6,0,0,1,0,0,Neocarzinostatin,NONE,P0A3S0,Involved in DNA binding,NONE,NONE,,,,"
"
1n7h_v,5,2.516,0.5032,-0.446257,0,2,2,0,1,0,"GDP-mannose 4,6 dehydratase 2",NONE,P93031,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1utr_v,4,2.011,0.5027,-2.17815,4,0,0,0,0,0,Uteroglobin,NONE,P17559,"Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.",NONE,NONE,,,,"
"
1ne4_v,6,3.013,0.5021,0.310383,0,4,1,0,1,0,cAMP-dependent protein kinase type I-alpha regulatory subunit,NONE,P00514,Signal transduction mechanisms,NONE,NONE,,,,"
"
1pt2_v,8,4.005,0.5007,2.79926,0,7,1,0,0,0,Levansucrase,NONE,P05655,Involved in levansucrase activity,NONE,NONE,,,,"
"
1rtv_v,5,2.503,0.5007,-1.27985,0,3,0,0,2,0,"DTDP-4-dehydrorhamnose 3,5-epimerase",NONE,Q9HU21,"Involved in dTDP-4-dehydrorhamnose 3,5-epimerase activity",NONE,NONE,,,,"
"
1mi4_v,7,3.503,0.5004,1.53143,0,4,1,0,2,0,3-phosphoshikimate 1-carboxyvinyltransferase,NONE,P0A6D3,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1pzo_v,6,3.002,0.5004,0.293971,4,2,0,0,0,0,Beta-lactamase TEM,NONE,P62593,"TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.",NONE,NONE,,,,"
"
1e7s_v,5,2.5,0.5,-1.11517,0,5,0,0,0,0,GDP-L-fucose synthetase,NONE,P32055,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1he2_v,6,2.99,0.4984,0.250319,4,1,0,0,1,0,Flavin reductase,NONE,P30043,Cell wall/membrane/envelope biogenesis,NONE,For the treatment of ariboflavinosis (vitamin B2 deficiency).,,,,"
"
1d2f_v,7,3.484,0.4977,1.30619,2,3,1,0,0,1,Protein malY,NONE,P23256,Acts as a beta-cystathionase and as a repressor of the maltose regulon.,NONE,NONE,,,,"
"
1buc_v,6,2.986,0.4977,0.614172,1,3,2,0,0,0,"Acyl-CoA dehydrogenase, short-chain specific",NONE,Q06319,Involved in acyl-CoA dehydrogenase activity,NONE,NONE,,,,"
"
1vqw_v,5,2.483,0.4966,-1.12319,0,5,0,0,0,0,SPBP16F5.08c protein,NONE,Q9HFE4,Involved in flavin-containing monooxygenase activity,NONE,NONE,,,,"
"
1w3y_v,7,3.475,0.4965,1.47981,4,1,1,0,1,0,Hyaluronate lyase,NONE,Q54873,Involved in hyaluronidase activity,NONE,"Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.",,,,"
"
1gzr_v,6,2.979,0.4965,0.337912,3,2,0,1,0,0,Insulin-like growth factor IA,NONE,P01343,NONE,NONE,NONE,,,,"
"
1o5f_v,5,2.482,0.4965,-0.52535,2,1,1,1,0,0,Serine protease hepsin,NONE,P05981,Plays an essential role in cell growth and maintenance of cell morphology,NONE,For treatment of hemorrhagic complications in hemophilia A and B,,,,"
"
1e7y_v,6,2.978,0.4964,0.35101,0,3,2,0,1,0,Glucose-6-phosphate 1-dehydrogenase,NONE,P11411,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1irj_v,7,3.472,0.496,1.60156,4,0,3,0,0,0,Protein S100-A9,METAL BINDING PROTEIN,S10A9_HUMAN,Expressed by macrophages in acutely inflammated tissues and in chronic inflammations. Seem to be an inhibitor of protein kinases. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermedi,NONE,NONE,,,,"
"
1jpz_v,7,3.47,0.4957,1.68676,4,3,0,0,0,0,Bifunctional P-450:NADPH-P450 reductase,NONE,P14779,Inorganic ion transport and metabolism,NONE,NONE,,,,"
"
2a3l_v,6,2.974,0.4957,0.629861,0,2,2,1,1,0,AMP deaminase,NONE,O80452,AMP deaminase plays a critical role in energy metabolism. Essential for the transition from zygote to embryo.,NONE,NONE,,,,"
"
1fsg_v,5,2.479,0.4957,-0.733261,0,2,3,0,0,0,Hypoxanthine-guanine-xanthine phosphoribosyltransferase,NONE,Q26997,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1jxm_v,7,3.469,0.4956,1.58183,0,4,2,0,1,0,Disks large homolog 4,NONE,P31016,Nucleotide transport and metabolism,NONE,For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.,,,,"
"
1w7n_v,6,2.973,0.4954,0.167033,1,2,1,1,1,0,Kynurenine--oxoglutarate transaminase 1,TRANSFERASE,KAT1_HUMAN,Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- eliminatio,NONE,NONE,,,,"
"
1i6v_v,7,3.467,0.4953,2.23228,2,2,2,1,0,0,DNA-directed RNA polymerase subunit alpha,NONE,Q9KWU8,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.,NONE,NONE,,,,"
"
1v30_v,6,2.971,0.4952,0.0864124,1,3,1,1,0,0,UPF0131 protein PH0828,NONE,O58558,Putative gamma-glutamylcyclotransferase.,NONE,NONE,,,,"
"
1s9j_v,9,4.455,0.495,1.81461,7,2,0,0,0,0,Dual specificity mitogen-activated protein kinase kinase 1,TRANSFERASE,MP2K1_HUMAN,Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.,"Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.",Colon tumor;Melanoma;Cancer;Rheumatoid arthritis;Non-small-cell lung cancer;Neurodegenerative disease;Breast tumor;Colorectal tumor;Transplant rejection;Inflammation;Pancreas tumor;Solid tumor,,,,"
"
1f7s_v,6,2.97,0.495,-0.125119,4,1,0,1,0,0,Actin-depolymerizing factor 1,NONE,Q39250,Involved in actin binding,NONE,NONE,,,,"
"
1mdx_v,7,3.462,0.4946,0.82096,2,3,1,0,1,0,UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase,NONE,Q8ZNF3,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1xuz_v,6,2.967,0.4946,-0.0651072,1,3,0,0,2,0,Capsule biosynthesis protein,NONE,Q57265,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1h4g_v,6,2.967,0.4945,0.443749,1,3,2,0,0,0,Glycoside hydrolase,NONE,Q7SIE3,"Involved in hydrolase activity, hydrolyzing O-glycosyl compounds",NONE,NONE,,,,"
"
1kji_v,5,2.472,0.4945,-0.632845,0,2,3,0,0,0,Phosphoribosylglycinamide formyltransferase 2,NONE,P33221,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1rfj_v,6,2.966,0.4944,0.0207399,4,2,0,0,0,0,Calmodulin-5/6/7/8,NONE,Q7DMN9,Involved in calcium ion binding,NONE,NONE,,,,"
"
2bkl_v,6,2.966,0.4943,-0.254721,3,3,0,0,0,0,Prolyl endopeptidase Pep,NONE,Q9X5N2,Involved in prolyl oligopeptidase activity,NONE,NONE,,,,"
"
1s4d_v,7,3.455,0.4935,1.33365,2,3,1,1,0,0,Uroporphyrinogen-III C-methyltransferase,NONE,P21631,Involved in methyltransferase activity,NONE,NONE,,,,"
"
1vbo_v,6,2.959,0.4931,0.243146,0,5,1,0,0,0,Mannose-specific lectin KM+,NONE,Q7M1T4,NONE,NONE,NONE,,,,"
"
1rc2_v,6,2.958,0.493,0.364282,3,0,3,0,0,0,Aquaporin Z,NONE,O68874,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1x92_v,5,2.463,0.4926,-1.04202,0,4,1,0,0,0,Phosphoheptose isomerase,NONE,Q9HVZ0,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1jjt_v,7,3.447,0.4925,0.740727,3,2,0,0,2,0,Beta-lactamase IMP-1,NONE,P52699,Involved in zinc ion binding,NONE,NONE,,,,"
"
1xqp_v,7,3.447,0.4924,1.66109,1,2,4,0,0,0,N-glycosylase/DNA lyase,NONE,Q8ZVK6,"DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates",NONE,NONE,,,,"
"
1t9a_v,6,2.953,0.4921,0.110285,3,3,0,0,0,0,"Acetolactate synthase catalytic subunit, mitochondrial",NONE,P07342,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1wap_v,5,2.459,0.4918,-0.942735,1,1,1,1,1,0,Transcription attenuation protein mtrB,RNA-BINDING ATTENUATION PROTEIN,MTRB_BACSU,Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptop,NONE,NONE,,,,"
"
1tjj_v,6,2.95,0.4917,0.392907,4,1,0,1,0,0,Ganglioside GM2 activator,NONE,P17900,Involved in sphingolipid activator protein activity,NONE,NONE,,,,"
"
1yaa_v,6,2.947,0.4911,-0.0287243,2,3,0,0,1,0,"Aspartate aminotransferase, cytoplasmic",NONE,P23542,"Involved in transferase activity, transferring nitrogenous groups",NONE,NONE,,,,"
"
1u3g_v,6,2.946,0.491,0.803438,1,1,1,3,0,0,Probable 5-formyltetrahydrofolate cyclo-ligase,NONE,P75430,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1qz9_v,6,2.943,0.4905,0.388851,2,3,0,0,0,1,Kynureninase,NONE,P83788,Involved in transaminase activity,NONE,NONE,,,,"
"
1jtb_v,6,2.94,0.4899,-0.319363,5,0,0,0,1,0,Nonspecific lipid-transfer protein 1,NONE,P07597,Involved in lipid binding,NONE,NONE,,,,"
"
1qcf_v,7,3.428,0.4897,0.823741,3,3,1,0,0,0,Tyrosine-protein kinase HCK,TYROSINE KINASE,HCK_HUMAN,May serve as part of a signaling pathway coupling the Fc receptor to the activation of the respiratory burst. May also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.,NONE,NONE,,,,"
"
1aod_v,5,2.443,0.4886,-0.724426,0,3,2,0,0,0,1-phosphatidylinositol phosphodiesterase,NONE,P34024,Involved in phospholipase C activity,NONE,NONE,,,,"
"
1qz6_v,6,2.931,0.4885,0.265737,0,5,1,0,0,0,"Actin, alpha skeletal muscle",NONE,P68135,Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,NONE,NONE,,,,"
"
1b5q_v,5,2.44,0.488,-0.957668,3,0,0,2,0,0,Polyamine oxidase,NONE,O64411,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1k8q_v,7,3.414,0.4878,1.17577,3,1,3,0,0,0,Gastric triacylglycerol lipase,NONE,P80035,Involved in triacylglycerol lipase activity,NONE,NONE,,,,"
"
1gte_v,7,3.412,0.4874,-0.153979,0,5,2,0,0,0,Dihydropyrimidine dehydrogenase [NADP+],NONE,Q12882,Amino acid transport and metabolism,NONE,For treatment of HIV AIDS,,,,"
"
1j3n_v,6,2.922,0.4871,-0.288397,0,4,0,0,2,0,Transferase,NONE,Q7SIC5,Involved in catalytic activity,NONE,NONE,,,,"
"
1rd4_v,6,2.922,0.487,-0.113176,5,0,0,1,0,0,Integrin alpha-L,IMMUNE SYSTEM,ITAL_HUMAN,"Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes an",NONE,NONE,,,,"
"
1ohv_v,6,2.921,0.4869,0.0333206,2,3,0,0,1,0,"4-aminobutyrate aminotransferase, mitochondrial",NONE,P80147,"Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.",NONE,NONE,,,,"
"
2f4j_v,8,3.892,0.4865,2.27858,4,1,3,0,0,0,Proto-oncogene tyrosine-protein kinase ABL1,NONE,P00519,Involved in protein kinase activity,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
2hpa_v,6,2.919,0.4865,0.220503,1,2,2,0,1,0,Prostatic acid phosphatase,HYDROLASE,PPAP_HUMAN,NONE,NONE,Prostate tumor,,,,"
"
1ot3_v,6,2.918,0.4864,0.258841,1,2,3,0,0,0,Deoxynucleoside kinase,NONE,Q9XZT6,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1u7g_v,5,2.432,0.4864,-0.666572,3,0,2,0,0,0,Ammonia channel,NONE,P69681,Inorganic ion transport and metabolism,NONE,NONE,,,,"
"
1r9o_v,7,3.398,0.4855,0.699503,4,2,0,0,1,0,Cytochrome P450 2C9,OXIDOREDUCTASE,CP2C9_HUMAN,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xe",NONE,NONE,,,,"
"
1a05_v,6,2.913,0.4855,-0.183615,1,3,0,0,2,0,3-isopropylmalate dehydrogenase,NONE,Q56268,Energy production and conversion,NONE,NONE,,,,"
"
1fhe_v,6,2.912,0.4853,0.502755,0,3,1,1,1,0,Glutathione S-transferase class-mu 26 kDa isozyme 47,NONE,P31670,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,NONE,NONE,,,,"
"
1xa1_v,6,2.912,0.4853,-0.387251,0,4,0,0,2,0,Regulatory protein blaR1,NONE,P18357,Defense mechanisms and antibiotic binding,NONE,NONE,,,,"
"
1jeo_v,6,2.912,0.4853,0.104216,0,6,0,0,0,0,3-hexulose-6-phosphate isomerase,NONE,Q58644,Involved in sugar binding,NONE,NONE,,,,"
"
1atl_v,6,2.911,0.4852,0.0526849,2,2,1,0,1,0,Zinc metalloproteinase atrolysin-D,NONE,P15167,Involved in metallopeptidase activity,NONE,NONE,,,,"
"
1xa9_v,6,2.911,0.4851,0.0596296,4,1,0,1,0,0,GFP-like fluorescent chromoprotein FP538,NONE,Q9U6Y4,Pigment protein that is yellow in color,NONE,NONE,,,,"
"
1c0n_v,6,2.91,0.4851,-0.108397,2,2,0,0,1,1,Cysteine desulfurase,NONE,P77444,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1tku_v,6,2.906,0.4843,-0.326901,0,4,1,0,1,0,"3,4-dihydroxy-2-butanone 4-phosphate synthase",NONE,Q5A3V6,"Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.",NONE,NONE,,,,"
"
1nft_v,6,2.902,0.4837,0.422682,0,3,0,2,1,0,Ovotransferrin,NONE,P02789,Involved in ferric iron binding,NONE,NONE,,,,"
"
1qj3_v,6,2.902,0.4837,-0.211232,2,2,1,0,1,0,Adenosylmethionine-8-amino-7-oxononanoate aminotransferase,NONE,P12995,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1fm4_v,9,4.352,0.4836,1.4676,4,3,2,0,0,0,Major pollen allergen Bet v 1-L,NONE,P43185,May be a general steroid carrier protein,NONE,NONE,,,,"
"
1i5d_v,6,2.902,0.4836,0.408439,0,3,1,0,2,0,Chemotaxis protein cheA,NONE,Q56310,Signal transduction mechanisms,NONE,NONE,,,,"
"
1jcj_v,6,2.901,0.4836,-0.0280204,1,3,1,0,1,0,Deoxyribose-phosphate aldolase,NONE,P0A6L0,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1y9q_v,6,2.901,0.4835,0.149687,2,2,0,1,1,0,"Transcriptional regulator, HTH_3 family",NONE,Q9KQN0,Involved in sequence-specific DNA binding,NONE,NONE,,,,"
"
1uf7_v,6,2.9,0.4834,-0.115785,1,2,2,0,1,0,N-carbamoyl-D-amino acid hydrolase,NONE,P60327,"Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds",NONE,NONE,,,,"
"
1fmc_v,8,3.867,0.4833,1.34106,5,3,0,0,0,0,7-alpha-hydroxysteroid dehydrogenase,NONE,P0AET8,Lipid transport and metabolism,NONE,NONE,,,,"
"
1qpl_v,9,4.349,0.4832,3.54964,4,4,1,0,0,0,Peptidyl-prolyl cis-trans isomerase FKBP1A,ISOMERASE,FKB1A_HUMAN,"May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of prot",NONE,NONE,,,,"
"
1vpv_v,7,3.381,0.483,0.591655,5,1,0,0,1,0,UPF0230 protein TM_1468,NONE,Q9X1H9,Energy production and conversion,NONE,NONE,,,,"
"
1shb_v,6,2.897,0.4828,0.555927,3,0,1,0,1,1,Tyrosine-protein kinase transforming protein Src,NONE,P00524,"This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro.",NONE,NONE,,,,"
"
1np0_v,6,2.896,0.4827,0.528526,1,1,3,1,0,0,Beta-hexosaminidase subunit beta,NONE,P07686,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1e2s_v,6,2.894,0.4824,0.293386,1,2,2,0,1,0,Arylsulfatase A,HYDROLASE,ARSA_HUMAN,Hydrolyzes cerebroside sulfate.,"Defects in ARSA are a cause of metachromatic leukodystrophy (MLD) [MIM:250100]. MLD is a disease characterized by intralysosomal storage of cerebroside-3-sulfate, as well as in the myelin membranes. Whereas storage occurs in many cells, the disease almost exclusively affects oligodendrocytes. Patients suffer from a progressive demyelination, which causes a variety of neurological symptoms, including gait disturbances, ataxias, optical atrophy, dementia, seizures, and spastic tetraparesis. Several years after the onset of the disease, patients die in a decerebrated state. Three forms of the disease can be distinguished according to the age at onset: late-infantile, juvenile and adult.;Arylsulfatase A activity is defective in multiple sulfatase deficiency (MSD) [MIM:272200]. MSD is a disorder characterized by decreased activity of all known sulfatases. MSD is due to defects in SUMF1 resulting in the lack of post- translational modification of a highly conserved cysteine into 3- oxoalanine. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.",Metachromatic leukodystrophy,,,,"
"
1bj4_v,6,2.894,0.4824,0.289413,2,4,0,0,0,0,"Serine hydroxymethyltransferase, cytosolic",TRANSFERASE,GLYC_HUMAN,Interconversion of serine and glycine.,NONE,NONE,,,,"
"
1isj_v,7,3.373,0.4818,1.71032,1,5,1,0,0,0,ADP-ribosyl cyclase 2,HYDROLASE,BST1_HUMAN,"Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.",Rheumatoid arthritis (RA) patients show enhanced expression of BST-1 transcripts in bone marrow stromal cell lines. This suggests that BST-1 overexpression may play a role in B-cell abnormalities in RA.,Hematological neoplasm;Multiple myeloma,,,,"
"
1q6i_v,5,2.408,0.4816,-0.787426,2,2,1,0,0,0,FKBP-type peptidyl-prolyl cis-trans isomerase fkpA,ISOMERASE,FKBA_ECOLI,PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,NONE,NONE,,,,"
"
1p9l_v,5,2.405,0.481,-1.34012,1,2,0,0,2,0,Dihydrodipicolinate reductase,NONE,P72024,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1svu_v,6,2.885,0.4808,0.461879,1,3,2,0,0,0,Modification methylase HhaI,NONE,P05102,Involved in DNA binding,NONE,NONE,,,,"
"
1sfy_v,6,2.884,0.4807,0.47508,0,3,3,0,0,0,Lectin,NONE,P16404,Involved in sugar binding,NONE,NONE,,,,"
"
1cvz_v,6,2.884,0.4807,0.508539,2,2,2,0,0,0,Papain,NONE,P00784,serpin family protein binding,NONE,NONE,,,,"
"
1nqa_v,6,2.883,0.4805,-0.508444,0,5,0,0,1,0,Glyceraldehyde-3-phosphate dehydrogenase,NONE,P00362,Involved in glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity,NONE,NONE,,,,"
"
1qci_v,5,2.403,0.4805,-1.36016,0,3,2,0,0,0,Antiviral protein I,NONE,P10297,Involved in rRNA N-glycosylase activity,NONE,"For nutritional supplementation, also for treating dietary shortage or imbalance",,,,"
"
1i1m_v,6,2.881,0.4802,0.101339,2,3,0,0,1,0,Branched-chain-amino-acid aminotransferase,NONE,P0AB80,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1l1y_v,6,2.881,0.4801,0.206276,0,3,3,0,0,0,Endoglucanase SS,NONE,P0C2S5,"This enzyme catalyzes the endohydrolysis of 1,4-beta- glucosidic linkages in cellulose, lichenin and cereal beta-D- glucans",NONE,NONE,,,,"
"
1m2x_v,6,2.876,0.4794,-0.180548,2,2,0,0,2,0,Carbapenem-hydrolyzing beta-lactamase blaB-1,NONE,O08498,Involved in zinc ion binding,NONE,NONE,,,,"
"
1v39_v,6,2.875,0.4792,0.618273,1,3,1,1,0,0,Cap-specific mRNA (nucleoside-2-O-)-methyltransferase,NONE,P07617,Involved in mRNA (nucleoside-2-O-)-methyltransferase activity,NONE,NONE,,,,"
"
1nxj_v,6,2.874,0.479,-0.230124,0,4,1,0,1,0,Regulator of ribonuclease activity A,NONE,P0A666,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1oht_v,5,2.394,0.4789,-1.37479,0,3,1,0,1,0,Peptidoglycan-recognition protein-LB,NONE,Q8INK6,Involved in N-acetylmuramoyl-L-alanine amidase activity,NONE,NONE,,,,"
"
1k72_v,7,3.352,0.4788,0.958077,0,4,3,0,0,0,Endoglucanase G,NONE,P37700,Involved in endoglucanase activity,NONE,NONE,,,,"
"
1de5_v,6,2.872,0.4787,0.172933,1,3,2,0,0,0,L-rhamnose isomerase,NONE,P32170,Involved in L-rhamnose isomerase activity,NONE,NONE,,,,"
"
1szk_v,6,2.872,0.4787,-0.152574,1,3,0,1,1,0,4-aminobutyrate aminotransferase,NONE,P22256,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1c2t_v,6,2.87,0.4784,0.1028,0,3,2,1,0,0,Phosphoribosylglycinamide formyltransferase,NONE,P08179,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1m6e_v,7,3.346,0.478,1.3879,2,2,2,1,0,0,S-adenosyl-L-methionine:salicylic acid carboxyl methyltransferase,NONE,Q9SPV4,Catalyzes the methylation of the free carboxyl end of the plant hormone salicylic acid (SA). Converts SA to SA methyl ester (MSA). The volatile compound MSA is hypothesized to act as an airborne signal that triggers defense responses in uninfected plants. MSA is an important chemoattractant for moth pollinated flowering plants.,NONE,NONE,,,,"
"
1a95_v,5,2.389,0.4779,-1.22835,0,3,2,0,0,0,Xanthine phosphoribosyltransferase,NONE,P0A9M5,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1mqq_v,6,2.864,0.4773,-0.356556,0,2,3,0,1,0,Alpha-glucuronidase,NONE,Q8VVD2,Involved in alpha-glucuronidase activity,NONE,NONE,,,,"
"
1dcy_v,5,2.385,0.4771,-1.80605,3,1,0,0,1,0,"Phospholipase A2, membrane associated",NONE,P14555,Involved in phospholipase A2 activity,NONE,NONE,,,,"
"
1s8g_v,6,2.861,0.4768,-0.351457,3,2,0,0,1,0,Phospholipase A2 homolog MT1,NONE,P49121,Involved in phospholipase A2 activity,NONE,NONE,,,,"
"
2gsa_v,6,2.859,0.4766,-0.108104,1,3,0,1,1,0,"Glutamate-1-semialdehyde 2,1-aminomutase",NONE,P24630,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1m4b_v,6,2.859,0.4765,0.258486,1,2,2,1,0,0,Interleukin-2,CYTOKINE,IL2_HUMAN,"Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cell",A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.,Cancer,,,,"
"
1jak_v,6,2.857,0.4762,0.168532,0,2,3,1,0,0,Calcium-activated potassium channel subunit beta-2,HYDROLASE,KCMB2_HUMAN,"Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete i",NONE,NONE,,,,"
"
2o9i_v,7,3.332,0.4761,0.624277,5,2,0,0,0,0,Nuclear receptor subfamily 1 group I member 2,TRANSCRIPTION,NR1I2_HUMAN,Orphan receptor; its natural ligand is probably pregnane. Binds to a response element in the CYP3A4 and ABCB1/MDR1 genes promoter. Activates its expression in response to a wide variety of endobiotics and xenobiotics.,NONE,NONE,,,,"
"
1i7g_v,6,2.853,0.4755,-0.251755,4,2,0,0,0,0,Peroxisome proliferator-activated receptor alpha,TRANSCRIPTION,PPARA_HUMAN,"Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the pero",NONE,Syndrome X;Lipid metabolism disorder;Non-insulin dependent diabetes;Atherosclerosis;Hypertriglyceridemia;Hyperlipidemia;Cardiovascular disease;Congestive heart failure;Diabetes mellitus;Obesity;Inflammation,,,,"
"
1q6r_v,6,2.851,0.4752,-0.229461,1,4,0,0,1,0,3-keto-L-gulonate-6-phosphate decarboxylase ulaD,NONE,P39304,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1hlc_v,6,2.851,0.4751,0.192276,0,3,3,0,0,0,Galectin-2,LECTIN,LEG2_HUMAN,This protein binds beta-galactoside. Its physiological function is not yet known.,NONE,NONE,,,,"
"
1l9n_v,8,3.797,0.4747,1.1012,3,4,1,0,0,0,Protein-glutamine gamma-glutamyltransferase E,TRANSFERASE,TGM3_HUMAN,Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. It is responsible for the later stages of cell envelope formation in the epidermis and the hair follicle.,NONE,NONE,,,,"
"
1re5_v,6,2.848,0.4746,-0.352637,0,4,0,0,2,0,"3-carboxy-cis,cis-muconate cycloisomerase",NONE,P32427,Involved in catalytic activity,NONE,NONE,,,,"
"
1a78_v,6,2.848,0.4746,0.246642,0,4,2,0,0,0,Galectin-1,NONE,P56217,Involved in sugar binding,NONE,NONE,,,,"
"
1egh_v,6,2.846,0.4744,-0.389725,1,4,0,0,1,0,Methylglyoxal synthase,NONE,P0A731,"cytosol, methylglyoxal synthase activity, methylglyoxal biosynthetic process",NONE,NONE,,,,"
"
1w1o_v,6,2.844,0.4739,0.339895,0,2,4,0,0,0,Cytokinin dehydrogenase 1,NONE,Q9T0N8,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1t7d_v,7,3.317,0.4738,1.54822,2,3,2,0,0,0,Signal peptidase I,NONE,P00803,"Intracellular trafficking, secretion, and vesicular transport",NONE,NONE,,,,"
"
1elv_v,6,2.843,0.4738,-0.00802578,0,3,1,1,1,0,Complement C1s subcomponent,HYDROLASE,C1S_HUMAN,"C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.",Defects in C1S are the cause of selective C1s deficiency [MIM:120580]; that is associated with early onset multiple autoimmune diseases.,Reperfusion injury;Capillary leak syndrome;Angioedema;Cardiovascular disease;Myocardial infarction;Transplant rejection;Hereditary angioedema;Ischemia;Inflammation,,,,"
"
1fe0_v,5,2.369,0.4738,-0.687684,0,2,3,0,0,0,Copper transport protein ATOX1,NONE,O00244,Involved in metal ion binding,NONE,NONE,,,,"
"
1r0y_v,6,2.842,0.4737,-0.506518,0,4,1,0,1,0,Cystic fibrosis transmembrane conductance regulator,NONE,P26361,Involved in nucleotide binding,NONE,NONE,,,,"
"
1mog_v,6,2.84,0.4733,0.148779,0,4,1,0,0,1,Vng1446h,NONE,Q9HPW4,NONE,NONE,For the treatment of ariboflavinosis (vitamin B2 deficiency).,,,,"
"
1jj0_v,6,2.838,0.4731,0.384885,0,3,3,0,0,0,Lysozyme C,NONE,P00698,Involved in lysozyme activity,NONE,"There is no support for the claim that aspartates are exercise performance enhancers, i.e. ergogenic aids.",,,,"
"
1xvp_v,6,2.837,0.4729,-0.363817,6,0,0,0,0,0,Nuclear receptor subfamily 1 group I member 3,DNA BINDING PROTEIN,NR1I3_HUMAN,Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the C,NONE,NONE,,,,"
"
1hlk_v,5,2.362,0.4725,-1.21858,0,3,0,0,1,1,Beta-lactamase type II,NONE,P25910,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1n8w_v,5,2.362,0.4725,-1.65092,0,3,0,1,1,0,Malate synthase G,NONE,P0A5J4,Energy production and conversion,NONE,NONE,,,,"
"
1b8g_v,6,2.834,0.4723,-0.266069,2,2,0,0,1,1,1-aminocyclopropane-1-carboxylate synthase,NONE,P37821,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1m0u_v,7,3.304,0.4721,1.26693,1,5,0,1,0,0,Glutathione S-transferase S1,NONE,P41043,"Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in the detoxification of metabolites produced during cellular division and morphogenesis (PubMed:1445191, PubMed:12547198).",NONE,NONE,,,,"
"
9aat_v,6,2.832,0.472,-0.245566,1,3,0,1,1,0,"Aspartate aminotransferase, mitochondrial",NONE,P00508,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1ucd_v,7,3.303,0.4719,1.04958,0,5,1,0,1,0,Ribonuclease MC,NONE,P23540,Involved in RNA binding,NONE,NONE,,,,"
"
1a2q_v,6,2.832,0.4719,-0.404198,2,3,0,0,1,0,Subtilisin BPN,NONE,P00782,"Posttranslational modification, protein turnover, chaperones",NONE,NONE,,,,"
"
1uej_v,6,2.831,0.4719,0.0368875,1,3,2,0,0,0,Uridine-cytidine kinase 2,NONE,Q9BZX2,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1vfm_v,6,2.831,0.4718,0.196573,0,2,4,0,0,0,Neopullulanase 2,NONE,Q08751,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1vyf_v,7,3.302,0.4717,0.207399,6,0,0,0,1,0,14 kDa fatty acid-binding protein,NONE,P29498,Involved in fatty acid binding,NONE,NONE,,,,"
"
1js3_v,6,2.83,0.4716,0.346789,2,1,2,0,0,1,Aromatic-L-amino-acid decarboxylase,NONE,P20711,Amino acid transport and metabolism,NONE,For nutritional supplementation and for treating dietary shortage or imbalance.,,,,"
"
1ii7_v,6,2.829,0.4715,-0.229686,1,5,0,0,0,0,DNA double-strand break repair protein mre11,NONE,Q8U1N9,"Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair (PubMed:11029422, PubMed:18854158, PubMed:18957200). The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA (PubMed:18957200). Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity (PubMed:11029422, PubMed:18854158, PubMed:18957200).",NONE,NONE,,,,"
"
1lv2_v,7,3.299,0.4713,0.457917,5,1,0,0,1,0,Hepatocyte nuclear factor 4-gamma,NONE,Q14541,Involved in transcription factor activity,NONE,NONE,,,,"
"
1u7l_v,6,2.826,0.4709,-0.654627,0,5,0,0,1,0,Vacuolar ATP synthase subunit C,NONE,P31412,Involved in ATP binding,NONE,NONE,,,,"
"
1efa_v,6,2.825,0.4709,0.210958,2,1,2,1,0,0,Lactose operon repressor,NONE,P03023,Involved in transcription factor activity,NONE,NONE,,,,"
"
1v84_v,6,2.822,0.4704,0.221463,0,3,3,0,0,0,Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1,TRANSFERASE,B3GA1_HUMAN,"Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphing",NONE,NONE,,,,"
"
1j2c_v,8,3.755,0.4693,2.09427,4,2,1,0,1,0,Heme oxygenase 1,NONE,P06762,Involved in heme oxygenase (decyclizing) activity,NONE,NONE,,,,"
"
1tlo_v,6,2.816,0.4693,0.382754,2,2,1,1,0,0,Calpain-1 catalytic subunit,NONE,P97571,Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,NONE,NONE,,,,"
"
1qip_v,7,3.284,0.4692,0.232056,3,1,0,1,2,0,Lactoylglutathione lyase,LYASE,LGUL_HUMAN,"Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.",NONE,Cancer,,,,"
"
1dc4_v,6,2.812,0.4687,-0.181792,1,5,0,0,0,0,Glyceraldehyde-3-phosphate dehydrogenase A,NONE,P0A9B2,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1wda_v,6,2.81,0.4684,-0.218107,2,2,1,1,0,0,Protein-arginine deiminase type-4,HYDROLASE,PADI4_HUMAN,"Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at Arg-8 and/or Arg-17 and histone H4 at Arg-3, which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinate","PADI4 is thought to be a rheumatoid arthritis susceptibility locus [MIM:180300]. Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.",NONE,,,,"
"
1s9t_v,6,2.809,0.4682,-0.130217,0,3,1,1,1,0,"Glutamate receptor, ionotropic kainate 2",NONE,P42260,"Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).",NONE,NONE,,,,"
"
1t43_v,6,2.809,0.4681,0.159543,2,2,0,1,0,1,Protein methyltransferase hemK,NONE,P0ACC1,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
1tub_v,6,2.807,0.4679,-0.306138,4,0,2,0,0,0,Tubulin alpha-1A chain,NONE,P02550,"Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.",NONE,NONE,,,,"
"
1o9w_v,6,2.806,0.4676,-0.267402,0,3,3,0,0,0,F17a-G fimbrial adhesin,NONE,Q99003,"Essential fimbrial adhesion factor that mediates binding to N-acetylglucosamine-containing receptors in the host intestinal microvilli, leading to colonization of the intestinal tissue, and diarrhea or septicemia. Also confers adhesiveness to laminin and basement membranes.",NONE,NONE,,,,"
"
1g0c_v,7,3.272,0.4674,1.38613,0,3,4,0,0,0,Endoglucanase,NONE,P19424,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1u4l_v,6,2.804,0.4673,0.0455798,0,5,1,0,0,0,C-C motif chemokine 5,ATTRACTANT,CCL5_HUMAN,"Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. R",NONE,NONE,,,,"
"
1vdv_v,6,2.801,0.4669,-0.10051,2,2,0,0,1,1,Xanthine dehydrogenase/oxidase,NONE,P80457,Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.,NONE,NONE,,,,"
"
1hov_v,7,3.263,0.4662,0.919975,4,1,2,0,0,0,72 kDa type IV collagenase,HYDROLASE/HYDROLASE INHIBITOR,MMP2_HUMAN,"In addition to gelatin and collagens, it cleaves KiSS1 at a Gly-",#NAME?,"Defects in MMP2 are the cause of multicentric osteolysis nodulosis and arthropathy (MONA) [MIM:605156]. Inherited osteolyses or vanishing bone syndromes are rare disorders of unknown etiology characterized by destruction and resorption of affected bones. MONA is an autosomal recessive osteolysis with multicentric involvement characterized by carpal and tarsal resorption, crippling arthritic changes, marked osteoporosis, palmar and plantar subcutaneous nodules and distinctive facies.;Defects in MMP2 are the cause of Winchester syndrome [MIM:277950]. Winchester syndrome is an autosomal recessive osteolysis syndrome. Winchester syndrome is severe with generalized osteolysis and osteopenia. Subcutaneous nodules are usually absent. Winchester syndrome has been associated with a number of additional features including coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. However, these features are not always present and have occasionally been observed in other osteolysis syndromes. The clinical and molecular findings suggest that Winchester syndrome and MONA are allelic disorders that form a continuous clinical spectrum.",NONE,,,"
"
1kf0_v,6,2.797,0.4662,-0.598112,0,4,0,0,2,0,Phosphoglycerate kinase 1,NONE,P00559,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1nhz_v,8,3.728,0.466,0.919075,7,1,0,0,0,0,Glucocorticoid receptor,HORMONE RECEPTOR,GCR_HUMAN,"Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and diff","Defects in NR3C1 are a cause of glucocorticoid resistance [MIM:138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.",Alzheimers disease;Immune deficiency;Breast tumor;Major depressive disorder;Glaucoma;Metabolic disorder;Psychotic disorder;HIV infection;Cocaine addiction;Inflammation;Planned abortion;Diabetes mellitus;Weight gain;Endometriosis;Obesity;Insulin dependent diabetes;Cushings disease;Glioma;Endometroid carcinoma;Neurodegenerative disease;Hypertension;Hepatitis C virus infection;Carcinoma;Non-insulin dependent diabetes;Psychiatric disorder,,,,"
"
1n97_v,6,2.795,0.4658,-0.603023,0,3,1,0,2,0,Cytochrome P450,NONE,Q746J6,Involved in monooxygenase activity,NONE,NONE,,,,"
"
1kjl_v,7,3.256,0.4652,0.974939,0,3,4,0,0,0,Galectin-3,SUGAR BINDING PROTEIN,LEG3_HUMAN,"Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryoge",NONE,Colorectal tumor;Chronic lymphocytic leukemia;Cancer;Prostate tumor;Pancreas tumor;Metastasis;Multiple myeloma,,,,"
"
1uby_v,6,2.791,0.4651,-0.42508,2,2,0,0,2,0,Farnesyl pyrophosphate synthetase,NONE,P08836,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1mfv_v,6,2.784,0.464,0.1213,0,2,4,0,0,0,Salivary alpha-amylase,NONE,P04745,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1h1h_v,6,2.784,0.464,-0.367865,0,4,0,0,2,0,Eosinophil cationic protein,NONE,P12724,Involved in nucleic acid binding,NONE,Used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists.,,,,"
"
1vsb_v,7,3.247,0.4639,1.00204,3,2,2,0,0,0,Subtilisin Carlsberg,NONE,P00780,"Posttranslational modification, protein turnover, chaperones",NONE,NONE,,,,"
"
1bgq_v,8,3.709,0.4636,1.62142,4,3,1,0,0,0,ATP-dependent molecular chaperone HSP82,NONE,P02829,"Posttranslational modification, protein turnover, chaperones",NONE,NONE,,,,"
"
1o98_v,6,2.781,0.4634,-0.715576,0,4,0,0,2,0,"2,3-bisphosphoglycerate-independent phosphoglycerate mutase",NONE,Q9X519,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1r00_v,9,4.17,0.4633,2.91187,2,4,2,1,0,0,RdmB,NONE,Q54527,Involved in O-methyltransferase activity,NONE,NONE,,,,"
"
1aj6_v,7,3.243,0.4633,0.379645,5,0,2,0,0,0,DNA gyrase subunit B,TOPOISOMERASE,GYRB_ECOLI,"DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.",NONE,NONE,,,,"
"
1wd4_v,6,2.779,0.4632,-0.147981,0,5,1,0,0,0,Alpha-N-arabinofuranosidase B,NONE,P42255,Involved in alpha-N-arabinofuranosidase activity,NONE,NONE,,,,"
"
2bu5_v,6,2.776,0.4627,-0.687163,5,1,0,0,0,0,"[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial",TRANSFERASE,PDK2_HUMAN,"Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.",NONE,NONE,,,,"
"
1ktg_v,6,2.771,0.4619,-0.346888,0,3,2,0,1,0,Bis(5-nucleosyl)-tetraphosphatase [asymmetrical],NONE,Q9U2M7,Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.,NONE,NONE,,,,"
"
1jqe_v,8,3.685,0.4607,0.940282,7,0,0,1,0,0,Histamine N-methyltransferase,NONE,P50135,Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine,NONE,For treatment of acute malarial attacks in non-immune subjects.,,,,"
"
1al8_v,8,3.684,0.4605,1.57964,4,2,2,0,0,0,Peroxisomal (S)-2-hydroxy-acid oxidase,NONE,P05414,Energy production and conversion,NONE,NONE,,,,"
"
1aec_v,10,4.603,0.4603,1.49852,2,4,4,0,0,0,Actinidain,NONE,P00785,Cysteine protease responsible for the cleavage of kiwellin into kissper and KiTH.,NONE,NONE,,,,"
"
2ncd_v,6,2.759,0.4599,-0.143991,0,4,0,0,1,1,Protein claret segregational,NONE,P20480,Involved in microtubule motor activity,NONE,NONE,,,,"
"
1i44_v,8,3.677,0.4596,0.544876,0,4,2,0,2,0,Insulin receptor,TRANSFERASE,INSR_HUMAN,This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators inclu,"Defects in INSR are the cause of insulin resistance (Ins resistance) [MIM:125853].;Defects in INSR are the cause of Rabson-Mendenhall syndrome [MIM:262190]; also known as Mendenhall syndrome. It is a severe insulin resistance syndrome characterized by insulin- resistant diabetes mellitus with pineal hyperplasia and somatic abnormalities. Typical features include coarse, senile-appearing facies, dental and skin abnormalities, abdominal distension, and phallic enlargement. Inheritance is autosomal recessive.;Defects in INSR are the cause of leprechaunism [MIM:246200]; also known as Donohue syndrome. Leprechaunism represents the most severe form of insulin resistance syndrome, characterized by intrauterine and postnatal growth retardation and death in early infancy. Inheritance is autosomal recessive.;Defects in INSR may be associated with noninsulin- dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2.;Defects in INSR are the cause of familial hyperinsulinemic hypoglycemia 5 (HHF5) [MIM:609968]. Familial hyperinsulinemic hypoglycemia [MIM:256450], also referred to as congenital hyperinsulinism, nesidioblastosis, or persistent hyperinsulinemic hypoglycemia of infancy (PPHI), is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels.;Defects in INSR are the cause of insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]. This syndrome is characterized by the association of severe insulin resistance (manifested by marked hyperinsulinemia and a failure to respond to exogenous insulin) with the skin lesion acanthosis nigricans and ovarian hyperandrogenism in adolescent female subjects. Women frequently present with hirsutism, acne, amenorrhea or oligomenorrhea, and virilization. This syndrome is different from the type B that has been demonstrated to be secondary to the presence of circulating autoantibodies against the insulin receptor.",Insulin dependent diabetes;Cancer;Non-insulin dependent diabetes;Infection;Parkinsons disease;Hypertension;Diabetes mellitus;Hyperinsulinemia,,,,"
"
1vp3_v,8,3.675,0.4594,1.96995,2,4,1,1,0,0,Cap-specific mRNA,NONE,P07617,Involved in mRNA (nucleoside-2-O-)-methyltransferase activity,NONE,NONE,,,,"
"
1jh7_v,6,2.748,0.458,-0.410989,0,4,2,0,0,0,Cyclic phosphodiesterase,NONE,O04147,Involved in cyclic-nucleotide phosphodiesterase activity,NONE,NONE,,,,"
"
1pmp_v,8,3.66,0.4574,0.632212,6,1,0,0,1,0,Myelin P2 protein,NONE,P02690,Involved in binding and lipid transport,NONE,NONE,,,,"
"
1u11_v,6,2.743,0.4572,-0.454245,0,4,0,0,2,0,N5-carboxyaminoimidazole ribonucleotide mutase,NONE,Q2QJL3,Involved in phosphoribosylaminoimidazole carboxylase activity,NONE,NONE,,,,"
"
1n8f_v,6,2.737,0.4562,-0.721953,1,3,0,0,2,0,"Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive",NONE,P0AB91,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1gxf_v,8,3.649,0.4561,0.872767,7,0,0,1,0,0,Trypanothione reductase,NONE,P28593,Energy production and conversion,NONE,NONE,,,,"
"
3cbs_v,9,4.097,0.4552,1.14468,6,2,0,0,1,0,Cellular retinoic acid-binding protein 2,NONE,P29373,Involved in retinoid binding,NONE,For topical treatment of cutaneous lesions in patients with AIDS-related Kaposis sarcoma.,,,,"
"
1kl2_v,6,2.727,0.4544,-0.215817,1,3,0,1,1,0,Serine hydroxymethyltransferase,NONE,Q5KUI2,Amino acid transport and metabolism,NONE,NONE,,,,"
"
2bet_v,8,3.628,0.4536,1.04895,1,5,1,0,1,0,Ribose-5-phosphate isomerase B,NONE,Q79FD7,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1v59_v,6,2.721,0.4536,-0.317694,0,4,2,0,0,0,"Dihydrolipoyl dehydrogenase, mitochondrial",NONE,P09624,Involved in oxidoreductase activity,NONE,NONE,,,,"
"
1g17_v,6,2.719,0.4532,-0.132942,0,2,4,0,0,0,Ras-related protein SEC4,NONE,P07560,Involved in GTP binding,NONE,NONE,,,,"
"
1ngs_v,6,2.717,0.4528,-0.335175,1,2,2,0,1,0,Transketolase 1,NONE,P23254,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1q0z_v,8,3.619,0.4524,1.73777,5,1,2,0,0,0,RdmC,NONE,Q54528,"Involved in the biosynthesis of the anthracycline aclacinomycin which is an aromatic polyketide antibiotic that exhibits high cytotoxicity and is widely applied in the chemotherapy of a variety of cancers. Catalyzes the removal of the methoxy group from the C-15 position of aclacinomycin T and A to yield 15-demethoxyaclacinomycin T and A, respectively.",NONE,NONE,,,,"
"
1dkf_v,8,3.615,0.4519,1.18535,5,3,0,0,0,0,Retinoic acid receptor alpha,HORMONE/GROWTH FACTOR RECEPTOR,RARA_HUMAN,This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.,Chromosomal aberrations involving RARA may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with ZBTB16/PLZF; translocation t(15;17)(q21;q21) with PML; translocation t(5;17)(q32;q11) with NPM.,Squamous cell carcinoma;Psoriasis;Colon tumor;Cancer;Metabolic disorder;Leukemia;Breast tumor;Skin infection;Neutropenia;Carcinoma;Dermatological disease;Ocular disease;Genital system disease;Lymphoma;Immune disorder,,,,"
"
1ua4_v,6,2.708,0.4513,-0.446472,0,2,4,0,0,0,ADP-dependent glucokinase,NONE,Q9V2Z6,Involved in phosphofructokinase activity,NONE,NONE,,,,"
"
1khr_v,8,3.605,0.4506,0.989287,6,1,1,0,0,0,Streptogramin A acetyltransferase,TRANSFERASE,VATD_ENTFC,"Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics.",NONE,NONE,,,,"
"
2ng1_v,8,3.604,0.4504,2.02351,0,6,2,0,0,0,Signal recognition particle protein,NONE,O07347,"Intracellular trafficking, secretion, and vesicular transport",NONE,NONE,,,,"
"
1se3_v,6,2.701,0.4502,0.00246855,0,3,2,0,1,0,Enterotoxin type B,NONE,P01552,"Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death",NONE,NONE,,,,"
"
1o8b_v,7,3.147,0.4496,0.190972,0,4,2,0,1,0,Ribose-5-phosphate isomerase A,NONE,P0A7Z0,Involved in the first step of the non-oxidative branch of the pentose phosphate pathway. It catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. Can also act on D-ribose-5-diphosphate and D-ribose-5-triphosphate as substrate.,NONE,NONE,,,,"
"
1y0x_v,6,2.694,0.449,-0.225539,4,0,1,0,1,0,Thyroid hormone receptor beta-2,NONE,P37243,Involved in transcription factor activity,NONE,"Used as replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyrodism during the recovery phase of subacute thyroiditis.",,,,"
"
3aig_v,8,3.587,0.4483,1.50243,3,2,2,0,1,0,Zinc metalloproteinase adamalysin-2,NONE,P34179,"Has no significant hemorrhagic activity, but inactivates serpins by limited proteolysis of their reactive-site loops.",NONE,NONE,,,,"
"
1b56_v,5,2.241,0.4481,-1.74171,3,1,0,0,1,0,"Fatty acid-binding protein, epidermal",LIPID-BINDING,FABP5_HUMAN,High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.,NONE,NONE,,,,"
"
1lh0_v,5,2.237,0.4474,-1.28966,0,3,2,0,0,0,Orotate phosphoribosyltransferase,NONE,P08870,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1r30_v,6,2.682,0.447,-0.203115,0,2,2,1,1,0,Biotin synthase,NONE,P12996,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1rsn_v,6,2.678,0.4464,-0.312462,0,3,2,0,1,0,Guanyl-specific ribonuclease Sa,NONE,P05798,Involved in RNA binding,NONE,NONE,,,,"
"
1pq2_v,7,3.123,0.4461,0.233013,5,1,0,0,1,0,Cytochrome P450 2C8,OXIDOREDUCTASE,CP2C8_HUMAN,"Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xe",NONE,NONE,,,,"
"
3e8r_v,5,2.23,0.4461,-0.676432,2,1,1,0,0,1,Disintegrin and metalloproteinase domain-containing protein 17,NONE,P78536,"Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.",NONE,NONE,,,,"
"
1bdg_v,6,2.675,0.4459,-0.311523,0,2,4,0,0,0,Hexokinase,NONE,Q26609,Involved in hexokinase activity,NONE,NONE,,,,"
"
1h8l_v,6,2.675,0.4458,-0.67481,1,2,0,1,2,0,Carboxypeptidase D,NONE,P83852,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1rj4_v,6,2.673,0.4456,-0.343154,0,3,2,1,0,0,Invertase inhibitor,NONE,O49908,Involved in enzyme inhibitor activity,NONE,NONE,,,,"
"
1j20_v,6,2.673,0.4454,-0.396566,1,3,1,0,1,0,Argininosuccinate synthase,NONE,P59846,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1rv7_v,8,3.56,0.445,0.88715,7,1,0,0,0,0,Protease,NONE,Q9QM22,Involved in aspartic-type endopeptidase activity,NONE,Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.,,,,"
"
1sez_v,7,3.111,0.4444,0.214669,4,1,0,0,1,1,"Protoporphyrinogen oxidase, mitochondrial",NONE,O24164,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
2c30_v,6,2.665,0.4442,-0.728512,0,4,1,0,1,0,Serine/threonine-protein kinase PAK 6,TRANSFERASE,PAK6_HUMAN,The activated kinase acts on a variety of targets (By similarity).,NONE,NONE,,,,"
"
1qfo_v,6,2.663,0.4438,-0.387331,0,1,4,0,1,0,Sialoadhesin,NONE,Q62230,"Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T- cells (By similarity). Preferentially binds to alpha2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis",NONE,NONE,,,,"
"
1svh_v,7,3.097,0.4424,0.685497,4,1,1,1,0,0,"cAMP-dependent protein kinase, alpha-catalytic subunit",NONE,P00517,Involved in protein serine/threonine kinase activity,NONE,NONE,,,,"
"
1htp_v,5,2.211,0.4422,-1.89656,2,1,1,1,0,0,"Glycine cleavage system H protein, mitochondrial",NONE,P16048,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1w27_v,8,3.535,0.4419,1.84921,2,4,2,0,0,0,Phenylalanine ammonia-lyase 1,NONE,P24481,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1ljr_v,7,3.092,0.4417,0.464548,1,3,1,1,1,0,Glutathione S-transferase theta-2,TRANSFERASE,GSTT2_HUMAN,Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.,NONE,NONE,,,,"
"
1kdr_v,6,2.647,0.4412,-0.563457,1,2,2,0,1,0,Cytidylate kinase,NONE,P0A6I0,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
8a3h_v,8,3.518,0.4398,1.56773,1,2,5,0,0,0,Endoglucanase B,NONE,P06565,NONE,NONE,NONE,,,,"
"
1m7z_v,6,2.639,0.4398,-0.585492,1,1,1,2,1,0,Nitric oxide synthase oxygenase,NONE,O34453,Involved in nitric-oxide synthase activity,NONE,NONE,,,,"
"
1s69_v,6,2.638,0.4397,-0.931976,0,4,1,0,1,0,Cyanoglobin,NONE,P73925,Involved in oxygen binding,NONE,NONE,,,,"
"
1g9t_v,9,3.955,0.4395,0.597804,0,6,3,0,0,0,Hypoxanthine phosphoribosyltransferase,NONE,P0A9M2,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1wop_v,5,2.197,0.4395,-1.40624,1,2,1,0,1,0,Aminomethyltransferase,NONE,Q9WY54,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1hrk_v,8,3.515,0.4394,0.962325,5,1,2,0,0,0,"Ferrochelatase, mitochondrial",NONE,P22830,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1r8c_v,6,2.629,0.4382,-0.865138,0,4,0,0,2,0,CCA-adding enzyme,NONE,O28126,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
1itu_v,8,3.499,0.4374,0.537927,4,2,1,0,1,0,Dipeptidase 1,HYDROLASE,DPEP1_HUMAN,Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.,NONE,NONE,,,,"
"
1qy8_v,9,3.933,0.437,1.92326,4,3,2,0,0,0,Endoplasmin,NONE,P41148,"Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).",NONE,NONE,,,,"
"
1fgs_v,6,2.622,0.437,-1.01749,0,4,0,0,2,0,Folylpolyglutamate synthase,NONE,P15925,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1w9v_v,5,2.182,0.4364,-1.10519,1,2,1,1,0,0,Chitinase,NONE,Q873X9,Involved in chitinase activity,NONE,NONE,,,,"
"
1ia7_v,7,3.054,0.4362,0.274817,0,5,2,0,0,0,Cellulase Cel9-M,NONE,Q9EYQ2,Involved in catalytic activity,NONE,NONE,,,,"
"
1os6_v,9,3.913,0.4348,1.2386,5,3,0,0,1,0,PpcA,NONE,Q8GGK7,Involved in iron ion binding,NONE,NONE,,,,"
"
1ciy_v,8,3.478,0.4347,1.58051,4,2,2,0,0,0,Pesticidal crystal protein cry1Aa,NONE,P0A366,Promotes colloidosmotic lysis by binding to the midgut epithelial cells of many lepidopteran larvae.,NONE,NONE,,,,"
"
1hyb_v,7,3.042,0.4346,-0.0409877,1,4,1,0,1,0,Nicotinamide-nucleotide adenylyltransferase,NONE,O26253,Involved in catalytic activity,NONE,NONE,,,,"
"
1k12_v,6,2.597,0.4329,-1.06698,1,4,1,0,0,0,Fucolectin,NONE,Q7SIC1,"Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens",NONE,NONE,,,,"
"
1oju_v,8,3.457,0.4321,1.85605,1,3,3,0,1,0,Malate dehydrogenase,NONE,O08349,Energy production and conversion,NONE,NONE,,,,"
"
1q3e_v,8,3.455,0.4318,1.36145,0,4,3,0,1,0,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,NONE,Q9JKA9,Signal transduction mechanisms,NONE,NONE,,,,"
"
1sjw_v,7,3.021,0.4315,0.419586,2,4,1,0,0,0,Nogalonic acid methyl ester cyclase,NONE,Q9RN59,NONE,NONE,NONE,,,,"
"
1v0p_v,9,3.881,0.4313,1.02782,4,3,1,0,1,0,Cell division control protein 2 homolog,NONE,Q07785,Involved in protein kinase activity,NONE,NONE,,,,"
"
1mlw_v,7,3.017,0.4311,0.0421452,1,4,2,0,0,0,Tryptophan 5-hydroxylase 1,OXIDOREDUCTASE,TPH1_HUMAN,NONE,NONE,NONE,,,,"
"
1d6s_v,8,3.448,0.431,0.336098,1,7,0,0,0,0,Cysteine synthase A,NONE,P0A1E3,"Two cysteine synthase enzymes are found, this enzyme and CysM; both catalyze the same reaction. Cysteine synthase B (CysM) can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product.",NONE,NONE,,,,"
"
1c47_v,8,3.445,0.4306,0.949631,0,5,1,0,2,0,Phosphoglucomutase-1,NONE,P00949,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1z4n_v,7,3.009,0.4299,0.141301,1,3,2,0,1,0,Beta-phosphoglucomutase,NONE,P71447,Involved in phosphoglucomutase activity,NONE,NONE,,,,"
"
1r50_v,6,2.579,0.4298,-0.74407,4,2,0,0,0,0,Lipase estA,NONE,P37957,Active toward p-nitrophenyl esters and triacylglycerides with a marked preference for esters with C8 acyl groups.,NONE,NONE,,,,"
"
1tzm_v,6,2.573,0.4289,-0.60169,2,2,0,0,1,1,1-aminocyclopropane-1-carboxylate deaminase,NONE,Q00740,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1kmq_v,5,2.136,0.4272,-1.40433,0,3,2,0,0,0,Transforming protein RhoA,NONE,P61586,Involved in GTP binding,NONE,For the treatment of hypercholesterolemia.,,,,"
"
1lzj_v,6,2.561,0.4268,-0.473762,2,2,2,0,0,0,B transferase,NONE,Q9NY01,"Involved in transferase activity, transferring hexosyl groups",NONE,NONE,,,,"
"
1g3m_v,7,2.985,0.4265,-0.192228,6,1,0,0,0,0,Estrogen sulfotransferase,TRANSFERASE,ST1E1_HUMAN,"May control the level of the estrogen receptor by sulfurylating free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol ",NONE,NONE,,,,"
"
1h0c_v,7,2.983,0.4262,-0.0501268,2,2,1,0,1,1,Serine--pyruvate aminotransferase,TRANSFERASE,SPYA_HUMAN,NONE,"Defects in AGXT are the cause of primary hyperoxaluria type I (PH1) [MIM:259900]; also known as oxalosis I. PH1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.",Hyperoxaluria,,,,"
"
2ioh_v,7,2.982,0.426,0.429785,4,1,0,0,0,2,Phosphonoacetaldehyde hydrolase,NONE,O31156,Involved in catalytic activity,NONE,NONE,,,,"
"
1t13_v,7,2.981,0.4258,0.526497,0,3,3,1,0,0,"6,7-dimethyl-8-ribityllumazine synthase 2",NONE,P61713,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1crb_v,9,3.83,0.4256,0.478661,9,0,0,0,0,0,"Retinol-binding protein I, cellular",NONE,P09455,Involved in retinoid binding,NONE,For the treatment of vitamin A deficiency.,,,,"
"
1khz_v,6,2.552,0.4253,-0.201725,0,3,3,0,0,0,ADP-ribose pyrophosphatase,NONE,Q93K97,Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.,NONE,NONE,,,,"
"
1dje_v,7,2.977,0.4252,-0.0625744,2,3,0,0,1,1,8-amino-7-oxononanoate synthase,NONE,P12998,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1lwx_v,7,2.974,0.4248,-0.202349,1,3,0,0,2,1,"Nucleoside diphosphate kinase, cytosolic",NONE,P22887,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1mdc_v,7,2.968,0.4241,-0.391747,5,1,0,0,1,0,Fatty acid-binding protein 2,NONE,P31417,Involved in binding,NONE,NONE,,,,"
"
1pjt_v,9,3.816,0.424,1.84911,2,4,2,1,0,0,Siroheme synthase,NONE,P25924,Involved in methyltransferase activity,NONE,NONE,,,,"
"
1t46_v,9,3.815,0.4239,1.60112,5,1,1,2,0,0,Mast/stem cell growth factor receptor,TRANSFERASE ACTIVATOR,KIT_HUMAN,This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K),Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes.;Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764].;Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).,Pancreas tumor;Ovary tumor;Cancer;Mastocytosis;Gastrointestinal tumor,,,,"
"
1r1j_v,8,3.388,0.4235,1.35788,2,2,2,0,2,0,Neprilysin,HYDROLASE,NEP_HUMAN,"Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradatio",Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.,Hypertension;Neuropathic pain;Renovascular hypertension;Congestive heart failure,,,,"
"
1lbm_v,7,2.963,0.4233,-0.0617888,1,5,0,0,1,0,N-(5-phosphoribosyl)anthranilate isomerase,NONE,Q56320,Involved in phosphoribosylanthranilate isomerase activity,NONE,NONE,,,,"
"
1m6d_v,7,2.962,0.4232,0.364736,3,2,2,0,0,0,Cathepsin F,NONE,Q9UBX1,Involved in cysteine-type endopeptidase activity,NONE,NONE,,,,"
"
1udc_v,6,2.535,0.4224,-0.278678,0,2,3,0,1,0,UDP-glucose 4-epimerase,NONE,P09147,Cell wall/membrane/envelope biogenesis,NONE,NONE,,,,"
"
1dqo_v,7,2.956,0.4223,-0.182536,1,5,0,0,1,0,Macrophage mannose receptor 1,NONE,Q61830,Involved in sugar binding,NONE,NONE,,,,"
"
1tzd_v,7,2.955,0.4222,0.0872638,0,4,1,0,2,0,Inositol-trisphosphate 3-kinase A,NONE,P17105,Involved in inositol trisphosphate 3-kinase activity,NONE,NONE,,,,"
"
1qvr_v,6,2.533,0.4222,-0.925228,0,3,1,0,2,0,Chaperone clpB,NONE,Q9RA63,Involved in nucleotide binding,NONE,NONE,,,,"
"
1lnx_v,5,2.111,0.4221,-1.87544,0,3,2,0,0,0,Small nuclear ribonucleoprotein homolog,NONE,Q8ZYG5,Transcription,NONE,NONE,,,,"
"
1ytv_v,8,3.374,0.4218,1.07082,0,7,1,0,0,0,Vasopressin V1a receptor,"SUGAR BINDING PROTEIN, HORMONE RECEPTOR",V1AR_HUMAN,"Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.",NONE,Emesis;Renal disease;Raynauds disease;Cardiac failure;Edema;Premature labor;Dysmenorrhea;Anxiety disorder;Hypertension;Motion sickness;Psychiatric disorder;Lung tumor;Cardiovascular disease,,,,"
"
1tft_v,7,2.95,0.4214,0.552327,3,1,2,1,0,0,Baculoviral IAP repeat-containing protein 4,APOPTOSIS,XIAP_HUMAN,"Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of ","Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2) [MIM:300635]. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.",Cancer;Skin tumor;Leukemia;Breast tumor;Lung tumor;Head and neck tumor;Uterine cervix tumor;Ovary tumor;Prostate tumor;Prostate hyperplasia,,,,"
"
2i3i_v,8,3.367,0.4209,1.30488,3,3,1,1,0,0,Baculoviral IAP repeat-containing protein 7,NONE,Q96CA5,"Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.",NONE,NONE,,,,"
"
1mmq_v,5,2.103,0.4206,-1.62963,1,2,2,0,0,0,Matrilysin,METALLOPROTEASE,MMP7_HUMAN,"Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.",NONE,NONE,,,,"
"
1ia5_v,7,2.936,0.4194,0.511512,0,4,3,0,0,0,Polygalacturonase 1,NONE,O74213,Involved in polygalacturonase activity,NONE,NONE,,,,"
"
1r7r_v,6,2.516,0.4194,-1.15439,0,4,2,0,0,0,Transitional endoplasmic reticulum ATPase,NONE,Q01853,Involved in nucleotide binding,NONE,NONE,,,,"
"
1qu2_v,7,2.935,0.4193,0.372427,4,1,2,0,0,0,Isoleucyl-tRNA synthetase,LIGASE/RNA,SYI1_STAAU,"Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activi",NONE,NONE,,,,"
"
1te2_v,5,2.096,0.4191,-2.15414,1,3,0,0,1,0,Phosphatase yniC,NONE,Q7ADF8,Involved in phosphatase activity,NONE,NONE,,,,"
"
2glr_v,8,3.352,0.419,1.65454,2,2,1,1,2,0,Glutathione S-transferase P 1,NONE,P19157,Involved in glutathione transferase activity,NONE,NONE,,,,"
"
1g9a_v,5,2.095,0.419,-2.08366,2,1,0,2,0,0,Botulinum neurotoxin type B,NONE,P10844,Involved in metalloendopeptidase activity,NONE,NONE,,,,"
"
1el4_v,8,3.352,0.4189,0.722501,3,2,2,0,0,1,Obelin,NONE,Q27709,Involved in calcium ion binding,NONE,NONE,,,,"
"
1o70_v,7,2.933,0.4189,-0.030265,0,5,2,0,0,0,Fasciclin-1,NONE,P10674,Neural cell adhesion molecule.,NONE,NONE,,,,"
"
6pfk_v,6,2.512,0.4187,-1.13367,1,3,0,0,2,0,6-phosphofructokinase,NONE,P00512,Carbohydrate transport and metabolism,NONE,NONE,,,,"
"
1cy1_v,5,2.093,0.4186,-2.22869,1,2,1,0,1,0,DNA topoisomerase 1,NONE,P06612,"Replication, recombination and repair",NONE,NONE,,,,"
"
1boo_v,8,3.347,0.4184,1.54742,1,3,3,1,0,0,Modification methylase PvuII,NONE,P11409,Involved in DNA binding,NONE,NONE,,,,"
"
1od6_v,9,3.765,0.4183,1.26444,1,5,3,0,0,0,Phosphopantetheine adenylyltransferase,NONE,Q72K87,Coenzyme transport and metabolism,NONE,NONE,,,,"
"
1xtq_v,5,2.09,0.4181,-1.34194,0,3,2,0,0,0,GTP-binding protein Rheb,NONE,Q15382,"Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.",NONE,NONE,,,,"
"
1lqp_v,5,2.088,0.4176,-2.5048,1,3,0,0,1,0,Glutathione transferase fosA,NONE,Q9I4K6,Metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin.,NONE,NONE,,,,"
"
1p5j_v,7,2.921,0.4172,-0.297259,2,4,0,0,1,0,L-serine dehydratase,NONE,P20132,Amino acid transport and metabolism,NONE,For nutritional supplementation and for treating dietary shortage or imbalance.,,,,"
"
1m32_v,7,2.92,0.4172,0.102765,1,4,0,0,1,1,2-aminoethylphosphonate--pyruvate transaminase,NONE,P96060,Involved in phosphonate degradation.,NONE,NONE,,,,"
"
1o26_v,8,3.336,0.4171,0.406161,1,4,2,0,1,0,Thymidylate synthase thyX,NONE,Q9WYT0,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1pzx_v,7,2.919,0.417,-0.321188,5,1,0,0,1,0,Lipid binding protein,NONE,P83812,NONE,NONE,NONE,,,,"
"
1a0g_v,7,2.918,0.4169,-0.181301,1,3,1,0,1,1,D-alanine aminotransferase,NONE,P19938,Amino acid transport and metabolism,NONE,NONE,,,,"
"
1ogg_v,7,2.918,0.4169,0.448606,1,4,1,1,0,0,Chitinase B,NONE,P11797,"Involved in hydrolase activity, hydrolyzing O-glycosyl compounds",NONE,NONE,,,,"
"
1x9d_v,7,2.918,0.4169,0.17064,0,5,2,0,0,0,"Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase",NONE,Q9UKM7,"Involved in mannosyl-oligosaccharide 1,2-alpha-mannosidase activity",NONE,NONE,,,,"
"
1ibj_v,7,2.917,0.4167,-0.207465,2,3,0,0,1,1,"Cystathionine beta-lyase, chloroplastic",NONE,P53780,"chloroplast, chloroplast stroma, cystathionine beta-lyase activity, cystathionine gamma-lyase activity, cystathionine gamma-synthase activity, pyridoxal phosphate binding, cysteine biosynthetic process via cystathionine, L-methionine biosynthetic process from L-homoserine via cystathionine, transsulfuration",NONE,NONE,,,,"
"
1oz0_v,8,3.331,0.4163,1.61891,2,2,3,0,1,0,Bifunctional purine biosynthesis protein PURH,NONE,P31335,Nucleotide transport and metabolism,NONE,NONE,,,,"
"
1rqi_v,7,2.913,0.4161,-0.523958,2,3,0,0,2,0,Geranyltranstransferase,NONE,P22939,"Posttranslational modification, protein turnover, chaperones",NONE,NONE,,,,"
"
1x6v_v,7,2.911,0.4159,-0.338821,0,5,1,0,1,0,Bifunctional 3-phosphoadenosine 5-phosphosulfate synthetase 1,NONE,O43252,Involved in ATP binding,NONE,NONE,,,,"
"
2ak3_v,7,2.908,0.4155,-0.337078,0,4,2,0,1,0,GT,NONE,P08760,Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.,NONE,NONE,,,,"
"
1mt5_v,9,3.734,0.4149,1.04844,7,2,0,0,0,0,Fatty-acid amide hydrolase,NONE,P97612,"Translation, ribosomal structure and biogenesis",NONE,NONE,,,,"
"
1hdc_v,9,3.734,0.4149,1.59409,6,3,0,0,0,0,3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase,NONE,P19992,Lipid transport and metabolism,NONE,NONE,,,,"
"